September 23, 2003

Mother's Milk: References

[1] World Health Organization (WHO). 1994. Brominated diphenyl ethers. Environmental Health Criteria 162. International Program on Chemical Safety.

[2] Lai, T.J.; Liu, X.; Guo, Y.L.; Guo, N.W.; Yu, M.L.; Hsu, C.C.; Rogan, W.J. 2002. A cohort study of behavioral problems and intelligence in children with high prenatal polychlorinated biphenyl exposure. Arch. Gen. Psychiatry. 59(11):1061-6.

[3] Kilburn, K.H. 2000. Visual and neurobehavioral impairment associated with polychlorinated biphenyls. Neurotoxicology. 21(4):489-99.

[4] Jacobson, J.L.; Jacobson, S.W. 2002. Association of prenatal exposure to an environmental contaminant with intellectual function in childhood. Journ. Clin. Tox. 40(4):467-75.

[5] Stein, J.; Schettler, T.; Wallinga, D.; Valenti, M. 2002. In harm's way: toxic threats to child development. J. Dev. Behav. Pediatr. 23(1 Suppl):S13-22.

[6] Stewart, P.; Reihman, J.; Lonky, E.; Darvill, T.; Pagano, J. 2000. Prenatal PCB exposure and neonatal behavioral assessment scale (NBAS) performance. Neurotoxicol. Teratol. 22(1):21-9.

[7] Eriksson, P.; Viberg, H.; Jakobsson, E.; Orn, U.; Fredriksson, A. 2002. A brominated flame retardant, 2,2',4,4',5-pentabromodiphenyl ether: uptake, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicol. Sci. 67(1):98-103.

[8] McDonald, T. 2003. Conference presentation: “Examining the Potential Health Risks Posed by PBDEs”. Environmental Finance Center, Brominated Flame Retardants and Foam Furniture Conference and Roundtable, San Francisco. April 29, 2003.

[9] Hale, R.C. et al. 2001. Polybrominated Diphenyl Ether Flame Retardants in Virginia Freshwater Fishes (USA). Environmental Science and Technology. 35(23):4585-4591.

[10] Bromine Science and Environmental Forum (BSEF). 2002. An introduction to brominated flame retardants. Brussels, Belgium, 1-28.

[11] de Wit, C. 2002. An overview of brominated flame retardants in the environment. Chemosphere. (46):583-624.

[12] Stewart, R. 2003. Flame retardants: an overview. Plastics Engineering. Jan. 1, 2003.

[13] Great Lakes Chemical. 2003.

[14] Albemarle. 2003.

[15] Chemical Marketing Reporter (CMR). 1995. Methyl Bromide Bill Riles Greens. July 3, 1995.

[16] Palm, A.; Cousins, I.; Mackay, D.; Tysklind, M.; Metcalfe, C.; Alaee, M. 2002. Assessing the environmental fate of chemicals of emerging concern: case study of the polybrominated diphenyl ethers. Environmental Pollution. (117):195-213.

[17] Christensen, J.H.; Glasius, M.; Pecseli, M.; Platz, J.; Pritzl, G. 2002. Polybrominated diphenyl ethers (PBDEs) in marine fish and blue mussels from southern Greenland. Chemosphere. 47(6):631-8.

[18] Ikonomou, M.G.; Rayne, S.; Addison, R.F. 2002. Exponential increases of the brominated flame retardants, polybrominated diphenyl ethers, in the Canadian arctic from 1981 to 2000. Environmental Science and Technology. 36(9):1886-92.

[19] Darnerud, P.O.; Eriksen, G.S.; Johannesson, T.; Larsen, P.B.; Viluksela, M. 2001. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environmental Health Perspectives. 109(Suppl 1):49-68.

[20] Strandman, T.; Kiviranta, H.; Kumpulainen, J.; Koistinen, J.; Vartiainen, T. 2001. Polybrominated Diphenyl Ethers in Finnish Food Items. Brominated Flame Retardants Conference, Burlington, Ontario. 307-310.

[21] de Böer, J.; Robertson, L.W.; Dettmer, F.; Wichmann, H.; Bahadir, M. 1998. Polybrominated diphenyl ethers in human adipose tissue and relation with watching television: case study. Organohalogen Compounds. (35):407-410.

[22] Jansson, B.; Asplund, L.; Olsson, M. 1987. Brominated flame retardants - ubiquitous environmental pollutants? Chemosphere. (16):2343-2349.

[23] Environmental Working Group (EWG). 2003. Tainted Catch. Toxic fire retardants are building up rapidly in San Francisco Bay fish - and people. July 2003.

[24] She, J.; Petreas, M.; Winkler, J.; Visita, P.; McKinney, M.; Kopec, D. 2002. PBDEs in the San Francisco Bay Area: measurements in harbor seal blubber and human breast adipose tissue. Chemosphere. 46(5):697-707.

[25] Rayne, S.; Ikonomou, M.G.; Antcliffe, B. Rapidly Increasing Polybrominated Diphenyl Ether Concentrations in the Columbia River System from 1992 to 2000. Environmental Science and Technology. 37 (13):2847-2854

[26] Luross, J.M.; Alaee, M.; Sergeant, D.B.; Cannon, C.M.; Whittle, D.M.; Solomon, K.R.; Muir, D.C. 2002. Spatial distribution of polybrominated diphenyl ethers and polybrominated biphenyls in lake trout from the Laurentian Great Lakes. Chemosphere. 46(5):665-72.

[27] Stern, G.A. and Ikonomou, M.G. 2000. Temporal trends of polybrominated diphenyl ethers in SE Baffin Beluga: increasing evidence of long-range atmospheric transport. Organohalogen Compounds. (47):81-84.

[28] Sjödin A, Jones RS, Lapeza C, Focant JF, Wang R, Turner WE, Needham LL, Patterson D. Retrospective time trend study of brominated flame retardants and polychlorinated biphenyls in human serum from various regions of the United States, 1985-2002. Organohalogen Compounds (61):1-3.

[29] Ryan, J.J.; Patry, B.; Mills, P.; Beaudoin, N.G. 2002. Recent trends in levels of Brominated Diphenyl Ethers (BDEs) in Human Milks from Canada. Organohalogen Compounds. (58):173-6.

[30] Norén, K and Meironyté, D. 2000. Certain organochlorine and organobromine contaminates in Swedish human milk in perspective of past 20-30 years. Chemosphere. (40):1111-1123.

[31] Alliance for Flexible Polyurethane Foam 2002. Millennium Report on Engineered Comfort

[32] Environ. 2003. Tier 1 Assessment of the potential health risks to children associated with exposure to the commercial Pentabromodiphenyl ether product. Voluntary Children’s Environmental Exposure Program Pilot (VCEEPP). Prepared by ENVIRON International Corporation for Great Lakes Chemical Corporation. April 21, 2003.

[33] Consumer Product Safety Commission (CPSC). 2003. Upholstered Furniture Flammability: Analysis of Comments from the CPSC Staff’s June 2002 Public Meeting.

[34] Sjödin A, Hagmar L, Klasson-Wehler E, Björk J, Bergman A. 2000. Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men. Environmental Health Perspectives (108):1035–41.

[35] Ohta, S.; Ishizuka, D.; Nishimura, H. et al. 2002. Comparison of polybrominated diphenyl ethers in fish, vegetables, and meats and levels in human milk of nursing women in Japan. Chemosphere. 46(5):689-96.

[36] Huwe JK, Lorentzsen M, Thuresson K, Bergman Å. 2002. Analysis of mono- to decabrominated diphenyl ethers in chickens at the part per billion level. Chemosphere (46)635–40.

[37] Lind Y, Aune M, Atuma S, Becker W, Bjerselius R, Glynn A, Darnerud PO. 2002. Food Intake of the Brominated Flame Retardants: PBDE’s and HBCD in Sweden. Organohalogen Compounds. (58):181-184.

[38] Betts, K. 2003. Why do PBDE levels vary widely? Environmental Science and Technology, Science News. 37(9): 164A-5A.

[39] Rudel RA, personal communication, June 19, 2003.

[40] Greenpeace. 2003. Consuming Chemicals: Hazardous chemicals in house dust as an indicator of chemical exposure in the home.

[41] Santillo D, et al. 2001. The presence of brominated flame retardants and organotin compounds in dusts collected from Parliament buildings from eight countries. Greenpeace Research Laboratories, Exeter, U.K., GRL-TN-03-2001.

[42] Hale R, La Guardia M, Harvey E, Mainor M. 2001. Brominated diphenyl ethers in land-applied sewage sludges in the US. The second international workshop on brominated flame retardants, Stockholm May 14 – 16,2001. 149-52.

[43] Sellström U. Determination of some polybrominated flame retardants in biota, sediment and sewage sludge. PhD Thesis. Department of Environmental Chemistry and Institute of Applied Environmental Research, Stockholm University; 1999. As cited by Sjödin A, 2003. [44]

[44] Sjödin A, Patterson DG, Bergman Å. 2003. A review of human exposure to brominated flame retardantsÑparticularly polybrominated diphenyl ethers. Environment International (29):829-839.

[45] Mazdai A, Dodder NG, Abernathy MP, Hites RA, Bigsby RM. 2003. Polybrominated diphenyl ethers in maternal and fetal blood samples. Environmental Health Perspectives (111)9:1249

[46] van Bavel, B.; Hardell, L.; Kitti, A.; Liljedahl, M.; Karlsson, M.; Pettersson, A.; Tysklind, M.; Linström, G. 2002. High levels of PBDEs in 5% of 220 blood samples from the Swedish population. Organohalogen Compounds. (58)161-164.

[47] Schecter A, Pavuk M, Päpke O, Ryan JJ, Birnbaum L, and Rosen R. 2003. Polybrominated Diphenyl Ethers (PBDEs) in U.S. Mothers' Milk Environmental Health Perspectives: doi:10.1289/Environmental Health Perspectives. 6466. [Online 7 August 2003]

[48] Betts, K. 2002. Rapidly rising PBDE levels in North America. Environmental Science and Technology, Science News. 36(3):50A-52A.

[49] Päpke O., 2001. Determination of PBDEs in human milk from the United States: comparison of results from three laboratories. Organohalogen Compounds (52)197-200.

[50] Petreas, M.; She, J.; Brown, F.R.; Winkler, J.; Windham, G.; Rogers, E.; Zhao, G.; Bhatia, R.; Charles, M.F. 2003. High Body Burdens of 2,2',4,4' - Tetrabromo Diphenyl Ether (BDE-47) in California Women. Environmental Health Perspectives, (111)9:1175.

[51] Meironyté-Guvenius D, Aronsson A, Ekman-Ordeberg G, Bergman Å, Norén K. 2003. Human pre- and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols and pentachlorophenol. Environmental Health Perspectives (111)9:1235

[52] European Union (EU). 2003. Directive 2003/11/EC of the European Parliament and of the Council of 6 February 2003 amending for the 24th time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances and preparations (pentabromodiphenyl ether, octabromodiphenyl ether), Official Journal L 42, 15.02.2003: 45-46; May 14-16 2001: 299-302.

[53] Strandman, T.; Koistinen, J.; Vartiainen, T. 2000. Polybrominated diphenyl ethers (PBDEs) in placenta and human milk. Organohalogen Compounds. (47):61-64.

[54] Krüger, C. 1988. Polybrominated biphenyls and polybrominated diphenyl ethers: detection and quantitation in selected foods. Ph.D. Thesis, University of Munster, Germany (in German). As cited by de Wit, C. 2002. An overview of brominated flame retardants in the environment. Chemosphere. (46):583-624.

[55] Meironyté, D.; Bergman, A. 1999. Analysis of Polybrominated Diphenyl Ethers in Swedish Human Milk, 1972-1997. Journal of Toxicology and Environmental Health. Part A, (58):329-341.

[56] Klaassen C. 1996. Casarett & Doull’s Toxicology: the basic science of poisons. 5th Edition. McGraw-Hill Press. New York, NY.

[57] Sjödin A, Patterson DG Jr, Bergman A. 2001. Brominated flame retardants in serum from U.S. blood donors. Environmental Science and Technology. 35(19):3830-3.

[58] Hooper K, She J. 2003. Lessons from the Polybrominated Diphenyl Ethers (PBDEs): Precautionary Principle, Primary Prevention, and the Value of Community-Based Body-Burden Monitoring Using Breast Milk. Environmental Health Perspectives (111)1:109-114

[59] Thomsen, C.; Lundanes, E.; Becher, G. 2002. Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environmental Science and Technology. 6(7):1414-8.

[60] Eriksson, P.; Fischer, C.; Fredriksson, A. 2003. Co-exposure to a polybrominated diphenyl ether (PBDE 99) and an ortho-substituted PCB (PCB 52) enhances developmental nuerotoxic effects. Organohalogen Compounds. (61):81-83.

[61] McDonald, T. 2003. Conference presentation “Examining the Potential Health Risks Posed by PBDEs: Environmental Finance Center, Brominated Flame Retardants and Foam Furniture Conference and Roundtable, San Francisco. April 29, 2003.

[62] Hallgren, S.; Darnerud, P.O. 2002. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology. (177):227-43.

[63] Porterfield, S.P. 1994. Vulnerability of the developing brain to thyroid abnormalities: environmental insult to the thyroid system. Environmental Health Perspectives. 102 (Suppl 2):125-30.

[64] Pop, V.J.; Kuijpens, J.L.; van Baar, A.L.; Verkerk, G.; van Son, M.M.; de Vijlder, J.J.; Vulsma, T.; Wiersinga, W.M.; Drexhage, H.A.; Vader, H.L. 1999. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin. Endocrinol. 50:149-155.

[65] Fowles, J.R.; Fairbrother, A.; Baecher-Steppan, L.; Kerkvliet, N.I. 1994. Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice. Toxicology. 86(1-2):49-61.

[66] Darnerud, P.O. and Sinjari, T. 1996. Effects of polybrominated diphenyls (PBDEs) and polychlorinated biphenyls (PCBs) on thyroxine and TSH blood levels in rats and mice. Organohalogen Compounds. (29):316-319.

[67] Hallgren, S. and Darnerud, P.O. 1998. Effects of polybrominate diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and chlorinated paraffins (CPs) on thyroid hormone levels and enzyme activities in rats. Organohalogen Compounds. (35):391-394.

[68] Zhou, T.; Ross, D.G.; DeVito, M.J.; Crofton, K.M. 2001. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol. Sci. 61(1):76-82.

[69] Zhou, T.; Taylor, M.M.; DeVito, M.J.; Crofton, K.M. 2002. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol. Sci. 66(1):105-16.

[70] Hallgren, S.; Sinjari, T.; Hakansson, H.; and Darnerud, P.O. 2001. Effects ofpolybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. Jun; 75(4): 200-8.

[71] van den Hove, M. F.; Beckers, C. et al. 1999. Hormone synthesis and storage in the thyroid of human preterm and term newborns: effect of thyroxine treatment. Biochimie. 81(5):563-70.

[72] US Environmental Protection Agency (USEPA). 2002. Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization (External Review Draft). U.S. Environmental Protection Agency, Office of Research and Development. Washington, D.C. NCEA-1-0503.

[73] US Environmental Protection Agency (USEPA). 1980. Health assessment of occupational exposure to polybrominated biphenyl (PBB) and polybrominated biphenyl oxide (PBBO). ISS EPA 560/6-80-001; NTIS PB81-159675. Washington DC. As cited in Darnerud, et al. 2001. [90]

[74] Viberg, H.; Fredriksson, A.; Eriksson, P. 2002. Neonatal exposure to the brominated flame retardant 2,2',4,4',5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouse. Toxicol. Sci. 67(1):104-7.

[75] Eriksson, P.; Jakobsson, E.; Fredriksson, A. 2001A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environmental Health Perspectives. 109(9):903-8.

[76] Branchi, I.; Alleva, E.; Costa, L.G. 2002. Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE99) on mouse neurobehavioural development. Neuro Toxicity. (23):375-384.

[77] Taylor, et al. 2003. Study on the development neurotoxicity of DE71 in rats - presented at the Society of Toxicologists meeting. As cited by L.S. Birnbaum in “New findings on PBDEs.” Talk presented at the Brominated Flame Retardants and Foam Furniture Conference and Roundtable. San Francisco, CA. April 29-30, 2003.

[78] McDonald, T. 2002. A perspective in the potential health risks of PBDEs. Chemosphere. (46):745-755.

[79] Laws et al. 2003. Study on the effects of DE71 on female rat pubertal development - presented at the Society of Toxicologists meeting. As cited by L.S. Birnbaum in “New findings on PBDEs” Talk presented at the Brominated Flame Retardants and Foam Furniture Conference and Roundtable. San Francisco, CA. April 29-30, 2003.

[80] Lichtensteiger, W.; Ceccatelli, R.; Faass, O.; Ma, R.; Schlumpf, M. 2003. Effect of polybrominated diphenylether and PCB on the development of the brain-gonadal axis and gene expression in rats. Organohologen Compounds. (61):84-87.

[81] Stoker, et al. 2003. Study on the effects of DE71 on male rat pubertal development - presented at the Society of Toxicologists meeting. As cited by L.S. Birnbaum in “New findings on PBDEs.” Talk presented at the Brominated Flame Retardants and Foam Furniture Conference and Roundtable. San Francisco, CA. April 29-30, 2003.

[82] Kuriyama, S. and Chahoud, I. 2003. Maternal exposure to low dose 2,2’4,4’,5 pentabromo diphenyl ether (PBDE 99) impairs male reproductive performance in adult male offspring. Organohologen Compounds. (61):92- 95.

[83] International Program of Chemical Safety (IPCS). 1994. Brominated Diphenyl Ethers. Environmental Health Criteria 162. World Health Organization, Geneva.

[84] Breslin, W.J.; Kirk, H.D.; Zimmer, M.A. 1989. Teratogenic evaluation of a polybromodiphenyloxide mixture in New Zealand white rabbits following oral exposure. Fundamentals of Applied Toxicology. (12):151-157.

[85] Norris, J.M.; Kociba, R.J.; Scwetz, B.A.; Rose, J.Q.; Humiston, C.G.; Jewett, G.L.; Gehring, P.J.; Mailhes, J.B. 1975. Toxicology of octabromobiphenyl and decabromodiphenyl oxide. Environmental Health Perspectives. (11):153-161.

[86] US Environmental Protection Agency (USEPA). 1986. Brominated Diphenyl Ethers. Chemical Hazard Information Profile. Washington DC.

[87] Talsness, C.E.; Shakibaei, M.; Kuriyama, S.; de Souza, C.; Chahoud, I. 2003. Ultrastructural changes in the ovaries of adult offspring following a single maternal exposure to low dose 2,2’,4,4’,5-pentabromodiphenyl ether. Organohologen Compounds. (61):88-91.

[88] National Toxicology Program (NTP). 1986. Toxicology and carcinogenesis studies of decabromodiphenyl oxide (CAS No 1163-19-5) in R344/N rats and B6C3F1 mice (feed studies). NTP technical report series no 309. Research Triangle Park, NC.

[89] Helleday, T.; Tuominen, K.L.; Bergman, A.; Jenssen, D. 1999. Brominated flame retardants induce intragenic recombination in mammalian cells. Mutat. Res. 439(2):137-47.

[90] McDonald T. 2003. Personal communication. September 4, 2003.

[91] Muir, T.; Alee, M. 2002. Costs and benefits of brominated flame retardants (BFRs) and alternatives. Organohalogen Compounds. 58:237-40.

[92] Muir, T.; Zegarac, M. 2001. Societal Costs of Exposure to Toxic Substances: economic and health costs of four case studies that are candidates for environmental causation. Environmental Health Perspectives. 109(Suppl 6): 885-902.

[93] Weiss B, Landrigan PJ. 2000. The developing brain and the environment: an introduction. Environmental Health Perspectives 108(Suppl 3):373.

[94] Swedish National Chemicals Inspectorate (SNCI). 1999. Phase-out of PBDEs and PBBs. Report on a Governmental Commission. Report No. 2/99.

[95] European Union (EU). 2002. Directive of the European Parliament and of the Council on the restriction of the use of certain hazardous substances in electrical and electronic equipment. Document PE-CONS 3662/02, Brussels, 8 Nov. 2002. Official Journal C 127E, 29.5.2003: 510-515.

[96] Darnerud, P.O.; Aune, M.; Atuma, S.; Becker, W.; Bjerselius, R.; Cnattingius, S.; Glynn, A. 2002. Time trend of polybrominated diphenyl ether (PBDE) levels in breast milk from Uppsala, Sweden, 1996-2001. Organohalogen Compounds (58):233-236.

[97] National Institute for Environmental Health Sciences (NIEHS) 2001. Toxicological Summary for Selected Polybrominated Diphenyl Ethers. Submitted by Bonnie Carson, Integrated Laboratory Systems, Research Triangle Park, North Carolina. March, 2001.

[98] Fredriksson VH, Jakobsson E, Örn U, Eriksson P. 2003. Neurobehavioural Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) During a Defined Period of Neonatal Brain Development. Toxicol Sci. Posted on-line Aug 12, 2003.

[99] Watanabe, I. and Tatsukawa, R. 1987. Formation of brominated dibenzofurans from the photolysis of fmale retardant decabromobiphenyl ether in hexane solution by UV and sunlight. Bull. Environ. Contam. Toxicol. (39):953-959.

[100] Sellström, U.; Soderstrom, G.; de Wit, C.; Tysklind, M. 1998. Photolytic debromination of decabromodiphenylether (deBDE). Organohalogen Compounds (35): 447-450.

[101] United States Environmental Protection Agency (USEPA). 2003. Summary of US EPA’s understanding of PBDEs. Office of Pollution Prevention and Toxic Substances. Washington DC. April 23, 2003.

[102] Peterman, P., Orazio, C, Feltz, K. 2003. Sunlight photolysis of 39 mono-hepta PBDE congeners in lipid. Organohalogen Compounds. (63):357-360.

[103] Tysklind M, Sellstrom U, Soderstrom, G, de Wit C. 2001. Abiotic transformation of polybrominated dephenylethers (PBDEs): Photolytic debrominated of decabromo diphenyl ether. Brominated Flame Retardants Conference, Burlington, Ontario. 42-45.

[104] Hermann, T., Schilling, B., Papke, O. 2003. Photolysis of PBDEs in solvents by exposure to daylight in a routine laboratory. Organohalogen Compounds (63):361-364.

[105] Environment California. 2003. Growing Threats: Toxic Flame Retardants And Children's Health. Environment California Research & Policy Center. April, 2003.

[106] Stashenko J. Revised rules issued on fire-retardant cigarettes. Associated Press State & Local Wire, August 22, 2003.

[107] Magnuson, L. 2003. Pollution Prevention Coordinator, EPA Region 9. Personal communication. May 20, 2003.

[108] Environmental Working Group (EWG). 2003. Body Burden: The Pollution in People. January, 2003. Washington, DC.

[109] United States Environmental Protection Agency (USEPA). 1998. Chemical hazard data availability study: What do we really know about the safety of high production volume chemicals? Office of Pollution Prevention and Toxic Substances. April, 1998.

[110] United States Environmental Protection Agency (USEPA). 2000. Voluntary Children's Chemical Evaluation Program. December 26, 2000. Federal Register. 65(248): 81699-81718.

[111] The Centers for Disease Control and Prevention (CDC). 2003. Second National Report on Human Exposure to Environmental Chemicals. January 2003. Available at:

[112] Danish Environmental Protection Agency. 1999. Brominated Flame Retardants. Substance Flow Analysis and Assessment of Alternatives. June 1999. Available at:

[113] Talsness CE, M Shakibaei, S Kuriyama, C de Souza, I Chahoud. 2003. Ultrastructural changes in the ovaries of adult offspring following a single maternal exposure to low dose 2,2',4,4',5-pentabromodiphenyl ether. Organohalogen Compounds. 61: 88-91.

[114] Sjödin A et. al. 1998. Gas chromatographic determination and quantification of polybrominated diphenyl ethers in a commercial product, Bromkal 70-5DE. J. Chromatogr. A 822:83-89

[115] International Programme on Chemical Safety. 1994. Brominated Diphenyl Ethers. Environmental Health Criteria 162. World Health Organization, Geneva.