Health issue
Level of Concern
Source
May cause an allergic skin reaction
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
Hexyl salicylate caused skin irritation in animals.
some
Nada Oršolić, Jadranka Skurić, Domagoj Dikić & Gabrijela Stanić. 2014. Inhibitory effect of a propolis on di-n-propyl disulfide or n-hexyl salycilate-induced skin irritation, oxidative stress and inflammatory responses in mice. Fitoterapia 93, 18-30.
Skin sensitization observed in animal testing.
some
A. Lapczynski, L. Jones, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on hexyl salicylate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S410-7.
Equivocal evidence of minor skin irritation in human and animal studies.
low
A. Lapczynski, L. Jones, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on hexyl salicylate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S410-7.
No evidence of skin sensitization in limited human testing.
low
Niels H. Bennike, Claus Zachariae & Jeanne D. Johansen. 2019. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics. Contact dermatitis 80(5), 325-327.
The European Commission's Scientific Committee on Consumer Safety reports this substance shows negative results for causing contact allergy in humans.
low
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)