Evidence
Health issue
Level of Concern
Source
Component: CITRAL
The National Toxicology Program reports this substances may cause kidney toxicity in laboratory animals at high doses.
Only in: Food Scores®
The National Toxicology Program reports this substances may cause kidney toxicity in laboratory animals at high doses.
Only in: Food Scores®
some
National Toxicology Program. 2003. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 505 NIH Publication No. 03-4439.
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
some
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
Component: CITRAL
May cause an allergic skin reaction
Only in: Household Cleaners
May cause an allergic skin reaction
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Component: CITRAL
Recognized by the European Union as a skin allergen
Recognized by the European Union as a skin allergen
some
EU Cosmetics Directive: Allergen list
Component: CITRAL
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
some
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
Component: CITRAL
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Component: CITRAL
The ACGIH reports this substance causes upper respiratory tract irritation.
The ACGIH reports this substance causes upper respiratory tract irritation.
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Component: CITRAL
The National Toxicology Program reports this substances may cause hyperplasia in laboratory animals at high doses.
Only in: Food Scores®
The National Toxicology Program reports this substances may cause hyperplasia in laboratory animals at high doses.
Only in: Food Scores®
some
National Toxicology Program. 2003. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 505 NIH Publication No. 03-4439.
Component: CITRAL
NTP Toxcast scored 2.5-3.5
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
May cause an allergic skin reaction
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes serious eye damage
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
A review article reports this substance may have anticarcinogenic activity
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
A peer-reviewed study reports that botanical oils prevent oxidative damage.
low
Kevin P. Anthony, Suziat A. Deolu-Sobogun & Mahmoud A. Saleh. 2012. Comprehensive assessment of antioxidant activity of essential oils. Journal of food science 77(8), C839-43.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
A review article reports this substance is not mutagenic
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
Component: CITRAL
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
