No Data, Some Concern
Skin Allergies &
Some Concern
Developmental &
Reproductive Toxicity
No Data, Some Concern
Low Concern
No Data, Some Concern
Top scoring factors: No information available on this substance.
BETULA PUBESCENS (WHITE BIRCH) BARK EXTRACT can be found in 46 products.
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Health issue
Level of Concern
A peer-reviewed article reports that birch bark extract impacted immune cell function in vitro.
Jona Freysdottir, Marino Boas Sigurpalsson, Sesselja Omarsdottir, Elin S. Olafsdottir, Arnor Vikingsson & Ingibjorg Hardardottir. 2011. Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitro. Immunology letters 136(1), 90-6.
Component: BETULIN
A peer-reviewed study reports this substance has antioxidant properties.
Wendan Zhang, Honghong Jiang, Jianxi Yang, Miaomiao Jin, Yingfeng Du, Qian Sun, Liang Cao & Huijun Xu. 2019. Safety assessment and antioxidant evaluation of betulin by LC-MS combined with free radical assays. Analytical biochemistry 587, 113460.
A human case study reports contact dermatitis caused by this substance.
Ulf Meyer-Hoffert & Jochen Brasch. 2013. Allergic contact dermatitis caused by betulin-containing triterpene extract from the outer bark of birch (Betula alba). Contact dermatitis 68(6), 382-3.
Component: BETULIN
A peer-reviewed article concludes this substance has low propensity to impact liver enzyme function based on in vitro tests.
Madhav Seervi, Shweta Lotankar, Shrikant Barbar & Sadhana Sathaye. 2016. Assessment of cytochrome P450 inhibition and induction potential of lupeol and betulin in rat liver microsomes. Drug metabolism and personalized therapy 31(2), 115-22.
Component: BETULIN
This substance was not mutagenic or genotoxic in an in vitro test.
T. S. Frolova, T. P. Kukina & O. I. Sinitsyna. 1900. [Genotoxic and Mutagenic Properties of Synthetic Betulinic and Betulonic Acids]. Bioorganicheskaia khimiia 41(4), 462-7.
Component: BETULIN
A review article reports that betulin has anticancer properties.
Sylwia Katarzyna Król, Michał Kiełbus, Adolfo Rivero-Müller & Andrzej Stepulak. 2015. Comprehensive review on betulin as a potent anticancer agent. BioMed research international 2015, 584189.
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EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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