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B

PROTEASE

Common Concerns

See how this product scores for common concerns.

  • SOME
    Asthma / Respiratory
  • No Data
    Skin Allergies & Irritation
  • No Data
    Developmental & Reproductive Toxicity
  • No Data
    Cancer
  • No Data
    Environment


Top Scoring Factors

No information available on this substance.


Ingredient concerns

  • CONCERNS
Health Issue Level of Concern Source
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among workers at detergent factories, detergent protease exposure is associated with respiratory disease

some

A. Brant, S. Upchurch, M. van Tongeren, C. Zekveld, J. Helm, F. Barnes, A. J. Newman Taylor & P. Cullinan. 2009. Detergent protease exposure and respiratory disease: case-referent analysis of a retrospective cohort. Occupational and environmental medicine 66(11), 754-8.

for workers at detergent factories, detergent enzyme exposure (proteases, alpha-amylase, lipase and cellulase) is associated with respiratory and allergic sensitization

some

F. G. B. G. J. van Rooy, R. Houba, N. Palmen, M. Zengeni, I. Sander, J. Spithoven, J. M. Rooyackers & D. J. J. Heederik. 2009. A cross-sectional study among detergent workers exposed to liquid detergent enzymes. Occupational and environmental medicine 66(11), 759-65.

for workers in detergent factories, detergent enzyme exposure is associated with occupational asthma

some

A. Brant, C. Zekveld, J. Welch, M. Jones, A. Newman Taylor & P. Cullinan. 2006. The prognosis of occupational asthma due to detergent enzymes: clinical, immunological and employment outcomes. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 36(4), 483-8.

for workers at detergent factories, detergent enzyme exposure (proteases, alpha-amylase, lipase and cellulase) is associated with respiratory and allergic sensitization

some

F. G. B. G. J. van Rooy, R. Houba, N. Palmen, M. Zengeni, I. Sander, J. Spithoven, J. M. Rooyackers & D. J. J. Heederik. 2009. A cross-sectional study among detergent workers exposed to liquid detergent enzymes. Occupational and environmental medicine 66(11), 759-65.

for workers at detergent factories, detergent enzyme exposure (proteases, alpha-amylase, lipase and cellulase) is associated with respiratory and allergic sensitization

some

F. G. B. G. J. van Rooy, R. Houba, N. Palmen, M. Zengeni, I. Sander, J. Spithoven, J. M. Rooyackers & D. J. J. Heederik. 2009. A cross-sectional study among detergent workers exposed to liquid detergent enzymes. Occupational and environmental medicine 66(11), 759-65.

6-month inhalation exposure to pre-spotter laundry detergent product was not associated with allergic sensitization

low

John A. Weeks, Robert A. Harper, Ronald A. Simon & Joel D. Burdick. 2011. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutaneous and ocular toxicology 30(4), 272-9.

European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life

low

EU Ecolabel: Detergents Ingredients Database

Review did not find a link between consumer exposure to detergent enzymes and respiratory sensitization

low

Katherine Sarlo, Donald B. Kirchner, Esperanza Troyano, Larry A. Smith, Gregory J. Carr & Carlos Rodriguez. 2010. Assessing the risk of type 1 allergy to enzymes present in laundry and cleaning products: evidence from the clinical data. Toxicology 271(3), 87-93.

A review article reports this substance is non-genotoxic

low

David Basketter, Ninna Berg, Cees Broekhuizen, Mark Fieldsend, Sheila Kirkwood, Cornelia Kluin, Sophie Mathieu & Carlos Rodriguez. 2012. Enzymes in cleaning products: An overview of toxicological properties and risk assessment/management. Regulatory toxicology and pharmacology : RTP.

The European Union Ecolabel program reports this substance is readily biodegradable.

low

EU Ecolabel: Detergents Ingredients Database

The European Union Ecolabel program reports this substance is anaerobically degradable.

low

EU Ecolabel: Detergents Ingredients Database



Understanding scores

EWG provides information on cleaning product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.

HOW WE DETERMINE SCORES

Hazard score

The Healthy Cleaning ingredient hazard score, from A to F, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend


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