Evidence
Health issue
Level of Concern
Source
nhalation of A. nobilis oil or one of its components elicited behavioral changes in rats.
some
Yingying Kong, Ting Wang, Rong Wang, Yichuan Ma, Shanshan Song, Juan Liu, Weiwei Hu & Shengtian Li. 2017. Inhalation of Roman chamomile essential oil attenuates depressive-like behaviors in Wistar Kyoto rats. Science China. Life sciences 60(6), 647-655.
Weak evidence of possible pregnancy/birth effects associated with chamomile consumption.
some
Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni. 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.
May cause an allergic skin reaction
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Derivatives of this species demonstrate neuromuscular effects in animals.
some
Zsolt Sándor, Loránd Barthó, Róbert Papp, Dezső Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & Dezső Csupor. 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323.
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
Allergic skin reaction observed in human case study.
some
B. C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
Animal testing shows evidence of antiinflammatory effects.
low
T. Rossi, M. Melegari, A. Bianchi, A. Albasini & G. Vampa. 1988. Sedative, anti-inflammatory and anti-diuretic effects induced in rats by essential oils of varieties of Anthemis nobilis: a comparative study. Pharmacological research communications 20 Suppl 5, 71-4.
A review article reports this substance may have anticarcinogenic activity
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
A peer-reviewed study reports that botanical oils prevent oxidative damage.
low
Kevin P. Anthony, Suziat A. Deolu-Sobogun & Mahmoud A. Saleh. 2012. Comprehensive assessment of antioxidant activity of essential oils. Journal of food science 77(8), C839-43.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
A review article reports this substance is not mutagenic
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
