Health issue
Level of Concern
Source
Component: ESTRAGOLE
Known to cause cancer
high
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Component: ESTRAGOLE
EPA's review of industry submitted toxicity data and the potential for human exposure concludes that this substance poses a moderate risk for human health.
some
Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Risks
Component: LINALOOL
Recognized by the European Union as a skin allergen
some
EU Cosmetics Directive: Allergen list
Component: LINALOOL
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
some
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
Component: LINALOOL
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Component: ESTRAGOLE
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Component: LINALOOL
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Component: LINALOOL
This peer-reviewed study reports this substance is a significant skin sensitizer after oxidation.
some
Johanna Bråred Christensson, Mihály Matura, Birgitta Gruvberger, Magnus Bruze & Ann-Therese Karlberg. 2010. Linalool--a significant contact sensitizer after air exposure. Contact dermatitis 62(1), 32-41.
Component: LINALOOL
This peer-reviewed study reports this substance is a significant skin sensitizer after oxidation.
some
Johanna Bråred Christensson, Pia Forsström, Ann-Marie Wennberg, Ann-Therese Karlberg & Mihály Matura. 2009. Air oxidation increases skin irritation from fragrance terpenes. Contact dermatitis 60(1), 32-40.
Component: LINALOOL
This peer-reviewed study reports this substance is a significant skin sensitizer after oxidation.
some
Deirdre A. Buckley. 2011. Allergy to oxidized linalool in the UK. Contact dermatitis 64(4), 240-1.
Component: LINALOOL
This peer-reviewed study reports this substance is a contact skin allergen.
some
Mihály Matura, Maria Sköld, Anna Börje, Klaus E. Andersen, Magnus Bruze, Peter Frosch, An Goossens, Jeanne D. Johansen, Cecilia Svedman, Ian R. White & Ann-Therese Karlberg. 2005. Selected oxidized fragrance terpenes are common contact allergens. Contact dermatitis 52(6), 320-8.
Component: LINALOOL
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
A review article reports this substance may have anticarcinogenic activity
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
A peer-reviewed study reports that botanical oils prevent oxidative damage.
low
Kevin P. Anthony, Suziat A. Deolu-Sobogun & Mahmoud A. Saleh. 2012. Comprehensive assessment of antioxidant activity of essential oils. Journal of food science 77(8), C839-43.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
A review article reports this substance is not mutagenic
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
Component: LINALOOL
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
Component: ESTRAGOLE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)