EWG's Guide to Healthy Cleaning | METHYLISOTHIAZOLINONE

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METHYLISOTHIAZOLINONE

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COMMONLY FOUND IN

air freshener cleaner, all-purpose/multi-surface cleaner, glass/window cleaner, mold and mildew remover, indoor cleaner, bathroom, general cleaner, tub/tile/sink cleaner, shower cleaner, soap scum remover drain opener, clog remover cleaner, hard water stain/mineral remover dish detergent or soap, baby bottle dish detergent or soap, dish washer dish detergent or soap, hand rinse aid, dish washer cleaner, carpet stain prevention/treatment, carpet cleaner, floor cleaner, wood (furniture/floor) cleaner, wood (furniture/floor) wax/polish/treatment, wood (furniture/floor) cleaner, fabric/upholstery deodorizer, fabric/upholstery/carpet stain prevention/treatment, fabric/upholstery cleaner, kitchen, general cleaner, granite/stone surfaces cleaner, degreaser, heavy duty cleaner, counter surface laundry additive laundry additive, stain remover laundry detergent laundry detergent, delicate/hand-wash laundry detergent, he/high efficiency laundry detergent, with fabric softener laundry detergent, with fabric softener, he/high efficiency laundry, fabric softener cleaner, metal, stainless steel stain remover and deodorizer, pet cleaner, toy cleaner, electronics cleaner, disinfectant wax/polish, wood (furniture only) laundry detergent pods, powder dish detergent or soap, dish washer pods, powder products for babies cleaner, professional laundry detergent, cold water

SYNONYMS

682M204, W-107150, UNII-15O9QS218W COMPONENT BEGLCMHJXHIJLR-UHFFFAOYSA-N, X5929, FT-0601044, DB-005250, AB0011560, CAS-2682-20-4, SC-16032, 2-METHYL-4-ISOTHIAZOLIN-3-ONE 100 MICROG/ML IN ACETONITRILE

RESTRICTED

EWG VERIFIED products cannot contain this ingredient without adequate substantiation.

Common Concerns

See how this product scores for common concerns.

No Data

Asthma / Respiratory
SOME

Skin Allergies & Irritation
No Data

Developmental & Reproductive Toxicity
No Data

Cancer
No Data

Environment

Top Scoring Factors

Evidence of acute aquatic toxicity; skin irritation/allergies/damage; cancer

Ingredient concerns

CONCERNS

Health Issue	Level of Concern	Source

The US EPA reports the LC50 value is very toxic to aquatic life.	high	U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life	some	EU Ecolabel: Detergents Ingredients Database
The US EPA reports this substance is a skin sensitizer.	some	U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
NIOSH reports that this substance is a skin sensitizer.	some	Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
The US EPA reports this substance causes skin irritation.	some	U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
A Cosmetic Ingredient Review Expert Panel found that methylchloroisothiazinolinone causes allergic contact dermatitis.	some	Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. 2010. Final report of the safety assessment of methylisothiazolinone. International journal of toxicology 29(4 Suppl), 187S-213S.
A Cosmetic Ingredient Review Expert Panel found that methylchloroisothiazinolinone is a skin sensitizer.	some	Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. 2010. Final report of the safety assessment of methylisothiazolinone. International journal of toxicology 29(4 Suppl), 187S-213S.
A review article reports that this substance causes contact allergies.	some	M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
A review article reports that this substance is a skin sensitizer.	some	M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
NIOSH reports that this substance is a skin irritant.	some	Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
A peer-reviewed study reports this substance causes dermatitis.	some	Robert Willi, Florian Pfab, Thomas Zilker, Jeroen Buters, Peter Schalock, Johannes Huss-Marp, Antonia Todorova, Johannes Ring & Ulf Darsow. 2011. Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. Contact dermatitis 64(6), 361-2.
A peer-reviewed study reports that this substance causes allergic contact dermatitis.	some	Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
A peer-reviewed study reports that this substance is a skin sensitizer.	some	Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
A peer-reviewed study reports that this substance is a skin sensitizer.	some	D. A. Basketter, R. Rodford, I. Kimber, I. Smith & J. E. Wahlberg. 1999. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact dermatitis 40(3), 150-4.
The US EPA reports it is unknown if this substance is carcinogenic.	low	U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
The European Union Ecolabel program reports this substance in inherently biodegradable.	low	EU Ecolabel: Detergents Ingredients Database
The US EPA reports this substance is unlikely to accumulate in fish at a significant level.	low	U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.