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LAURTRIMONIUM CHLORIDE

 

Unacceptable: EWG VERIFIED products cannot contain this ingredient.

Asthma/Respiratory
 
Moderate Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
Some Concern
 
Cancer
 
No Data, Some Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of respiratory effects; acute aquatic toxicity; chronic aquatic toxicity
LAURTRIMONIUM CHLORIDE can be found in 4 products.
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Evidence

Health issue
 
Level of Concern
 
Source
A structurally similar compound is know to be an asthmagen (sensitizing).
 
moderate
 
2020. Environmental Working Group. 2020. Quaternary ammonium compounds structural similarities.
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
 
some
 
EU Ecolabel: Detergents Ingredients Database
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
 
some
 
EU Ecolabel: Detergents Ingredients Database
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
 
some
 
European Chemicals Agency (ECHA): GHS Data from ECHA Website
EPA's review of industry submitted toxicity data and the potential for human exposure concludes that this substance poses a moderate risk for human health.
 
some
 
Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Risks
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
 
some
 
Vanessa E. Melin, Travis E. Melin, Brian J. Dessify, Christina T. Nguyen, Caroline S. Shea & Terry C. Hrubec. 2015. Quaternary Ammonium Disinfectants Cause Subfertility in Mice by Targeting both Male and Female Reproductive Processes. Reproductive toxicology (Elmsford, N.Y.).
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
 
some
 
Vanessa E. Melin, Haritha Potineni, Patricia Hunt, Jodi Griswold, Bill Siems, Stephen R. Werre & Terry C. Hrubec. 2014. Exposure to common quaternary ammonium disinfectants decreases fertility in mice. Reproductive toxicology (Elmsford, N.Y.) 50, 163-70.
Quaternary ammonium compounds detected in human blood was associated with increased inflammation, decreased mitochondrial function and disruption of cholesterol.
 
some
 
Terry C. Hrubec, Ryan P. Seguin, Libin Xu, Gino A. Cortopassi, Sandipan Datta, Alexandra L. Hanlon, Alicia J. Lozano, Valerie A. McDonald, Claire A. Healy, Tyler C. Anderson, Najaha A. Musse & Richard T. Williams. 2021. Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure. Toxicology reports 8, 646-656.
may cause respiratory irritation
Only in: Household Cleaners
 
some
 
European Chemicals Agency (ECHA): GHS Data from ECHA Website
NTP Toxcast scored 1.5-2.5
 
some
 
National Toxicology Program (NTP): EWG Toxcast Analysis
Harmful if swallowed
Only in: Household Cleaners
 
some
 
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
 
some
 
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes serious eye damage
Only in: Household Cleaners
 
some
 
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes skin irritation
Only in: Household Cleaners
 
some
 
European Chemicals Agency (ECHA): GHS Data from ECHA Website
causes serious eye irritation
Only in: Household Cleaners
 
some
 
European Chemicals Agency (ECHA): GHS Data from ECHA Website
This substance impacted cholesterol biosynthesis.
 
some
 
Josi Herron, Rosalyn C. Reese, Keri A. Tallman, Rohini Narayanaswamy, Ned A. Porter & Libin Xu. 2016. Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. Toxicological sciences : an official journal of the Society of Toxicology 151(2), 261-70.
Quaternary ammonium compounds altered neurodevelopment in cells.
 
some
 
Josi M. Herron, Hideaki Tomita, Collin C. White, Terrance J. Kavanagh & Libin Xu. 2021. Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-D in Vitro Model of Neurodevelopment. Chemical research in toxicology 34(5), 1265-1274.
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.
 
some
 
Cosmetic Ingredient Review (CIR): CIR Assessments
The European Union Ecolabel program reports this substance in inherently biodegradable.
 
low
 
EU Ecolabel: Detergents Ingredients Database
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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