Evidence
Health issue
Level of Concern
Source
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
some
EU Ecolabel: Detergents Ingredients Database
European Union Ecolabel program data shows this substance has high acute toxicity to aquatic life
some
EU Ecolabel: Detergents Ingredients Database
A review of industry studies finds alkyl betaines have acute oral toxicity (LD50) as low as 1190 mg/kg.
some
Xavier Domingo. 1996. Betaines. New York: Marcel Dekker.
Causes serious eye damage
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
causes serious eye irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
A Cosmetic Ingredient Review Expert Panel found that the lowest acute oral toxicity LD50 for cocamidopropyl betaine is 4,910 mg/kg body weight.
low
Cosmetic Ingredient Review. 1991. Final Report on the Safety Assessment of Cocamidopropyl Betaine. International Journal of Toxicology 10(1), 33-52.
A Cosmetic Ingredient Review Expert Panel found that cocoamidopropyl betaine is not a dermal sensitizer particularly at concentrations of 10 percent or less.
low
Cosmetic Ingredient Review. 1991. Final Report on the Safety Assessment of Cocamidopropyl Betaine. International Journal of Toxicology 10(1), 33-52.
A review of industry studies shows amidopropyl betaines have low dermal acute toxicity.
low
Xavier Domingo. 1996. Betaines. New York: Marcel Dekker.
This chemical has been verified to be of low concern in cleaning products based on experimental and modeled data as assessed by the EPA.
low
Environmental Protection Agency (EPA): Safer Chemical Ingredients List (2018-02-28)
A Cosmetic Ingredient Review Expert Panel found that cocamidopropyl betaine did not cause genotoxicity in four studies.
low
Cosmetic Ingredient Review. 1991. Final Report on the Safety Assessment of Cocamidopropyl Betaine. International Journal of Toxicology 10(1), 33-52.
A review of industry studies finds alkyl betaines did not cause cell mutation in a standardized test.
low
Xavier Domingo. 1996. Betaines. New York: Marcel Dekker.
The European Union Ecolabel program reports this substance is readily biodegradable.
low
EU Ecolabel: Detergents Ingredients Database
The European Union Ecolabel program reports this substance is anaerobically degradable.
low
EU Ecolabel: Detergents Ingredients Database
Impurities
Health issue
Level of Concern
Source
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
May cause an allergic skin reaction
Only in: Household Cleaners
May cause an allergic skin reaction
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
Causes severe skin burns and eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
Harmful in contact with skin
Only in: Household Cleaners
Harmful in contact with skin
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
may cause respiratory irritation
Only in: Household Cleaners
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
may cause respiratory irritation
Only in: Household Cleaners
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
NTP Toxcast scored 1.5-2.5
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
Causes serious eye damage
Only in: Household Cleaners
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
Causes serious eye damage
Only in: Household Cleaners
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
causes serious eye irritation
Only in: Household Cleaners
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
May cause an allergic skin reaction
Only in: Household Cleaners
May cause an allergic skin reaction
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: LAURAMIDOPROPYL DIMETHYLAMINE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: 3-DIMETHYLAMINOPROPYLAMINE
Not known to cause asthma
Not known to cause asthma
low
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
