Health issue
Level of Concern
Source
Renal failure occurred in an adult man who ingested dipropylene glycol .
some
Frank LoVecchio, Cameron Nourani, D. J. Watts, K. L. Wallance & P. M. Wax. 2008. Acute renal failure, neuropathy, and myopathy after ingestion of dipropylene glycol fog solution. The American journal of emergency medicine 26(5), 635.e1-2.
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Effects on kidneys observed at high doses in chronic toxicity study in rats.
some
2004. NTP toxicology and carcinogensis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program technical report series(511), 6-260.
Contact dermatitis was rarely observed in a human patch test study with 500 participants.
some
J. D. Johansen, G. B. Jemec & S. C. Rastogi. 1995. Contact sensitization to dipropylene glycol in an eczema population. Contact dermatitis 33(3), 211-2.
Mild skin irritant in animal tests.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
Eye irritant in animal tests.
low
Cosmetic Ingredient Review (CIR): CIR Assessments
acute toxicity, dermal LD50 (mg/kg)
low
Cosmetic Ingredient Review (CIR): CIR Assessments
Low acute oral toxicity.
low
Cosmetic Ingredient Review (CIR): CIR Assessments
No evidence of cancer in chronic high dose animal study
low
Michelle J. Hooth, Ronald A. Herbert, Joseph K. Haseman, Denise P. Orzech, Jerry D. Johnson & John R. Bucher. 2004. Toxicology and carcinogenesis studies of dipropylene glycol in rats and mice. Toxicology 204(2-3), 123-40.
No reproductive or developmental toxicity observed in animal studies.
low
Jeff R. Fowles, Marcy I. Banton & Lynn H. Pottenger. 2013. A toxicological review of the propylene glycols. Critical reviews in toxicology 43(4), 363-90.
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
Only in: Household Cleaners
low
EU Ecolabel: Detergents Ingredients Database
The European Union Ecolabel program reports this substance is readily biodegradable.
low
EU Ecolabel: Detergents Ingredients Database
Health issue
Level of Concern
Source
Impurity: ETHYLENE OXIDE
May cause genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
May cause cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to females)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to males)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: ETHYLENE OXIDE
Known To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: 1,4-DIOXANE
Suspected of causing cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: 1,4-DIOXANE
Reasonably Anticipated To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: ETHYLENE OXIDE
Toxic if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes pulmonary edema
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes skin corrosion
Only in: Oven Cleaner; Drain Opener/Clog Remover
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes reproductive effects
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes leukemia
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes peritoneal cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
cancer
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
central nervous system impairment
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
Asthmagen (irritation)
some
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
Impurity: 1,4-DIOXANE
Causes cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
liver damage
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
suspected human carcinogen
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: 1,4-DIOXANE
Possibly carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: 1,4-DIOXANE
confirmed animal carcinogen with unknown relevance to humans
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes eye corrosion
Only in: Drain Opener/Clog Remover; Oven Cleaner
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
Impurity: 1,4-DIOXANE
EPA testing shows this substance has low acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database