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BETA-IONONE

 
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
Low Concern
 
Cancer
 
No Data, Some Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of acute aquatic toxicity; skin irritation/allergies/damage; digestive system effects
beta-IONONE can be found in 5 products.
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Evidence

Health issue
 
Level of Concern
 
Source
EPA testing shows this substance has very high acute toxicity to aquatic life
 
some
 
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
NTP Toxcast scored 2.5-3.5
 
some
 
National Toxicology Program (NTP): EWG Toxcast Analysis
Categorised as possible contact allergen.
 
some
 
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
Evidence of skin irritation in animal testing.
 
some
 
J. Lalko, A. Lapczynski, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on beta-ionone. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S241-7.
Impacts on liver enzyme function observed in rats.
 
some
 
T. C. Jeong, H. K. Gu, Y. J. Chun, C. H. Yun, S. Han & J. K. Roh. 1998. Effects of beta-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague Dawley rats. Chemico-biological interactions 114(1-2), 97-107.
Impacts on liver enzyme activity observed in mice.
 
some
 
T. C. Jeong, H. K. Gu, J. I. Park, H. I. Yun, H. C. Kim, C. S. Ha & J. K. Roh. 1999. Pretreatment of male BALB/c mice with beta-ionone potentiates thioacetamide-induced hepatotoxicity. Toxicology letters 105(1), 39-46.
Impacts on liver enzyme function observed in rats.
 
some
 
Hye Gwang Jeong, Young-Jin Chun, Chul-Ho Yun, Chang-Kiu Moon, Hye-Sook Lee, Sang Seop Han, Eung-Seok Lee & Tae Cheon Jeong. 2002. Induction of cytochrome P450 1A and 2B by alpha- and beta-ionone in Sprague Dawley rats. Archives of pharmacal research 25(2), 197-201.
Cellular assays show evidence of endocrine activity.
 
some
 
National Toxicology Program (NTP): EWG Toxcast Analysis
Evidence of eye irritation in animal testing.
 
low
 
J. Lalko, A. Lapczynski, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on beta-ionone. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S241-7.
No evidence of skin sensitization in human or animal testing.
 
low
 
J. Lalko, A. Lapczynski, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on beta-ionone. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S241-7.
No evidence of developmental or reproductive toxicity in animal testing.
 
low
 
J. Lalko, A. Lapczynski, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on beta-ionone. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S241-7.
In vitro testing with bacteria found no evidence of genotoxicity.
 
low
 
J. Lalko, A. Lapczynski, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on beta-ionone. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S241-7.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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