EPA's review of industry submitted toxicity data concludes that this substance poses a high hazard based on the possibility of persistence, bioaccumulation, aquatic toxicity and impacts to human health.

moderate

Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Hazards

No skin sensitization was observed in human or animal tests.

low

A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.

Low toxicity observed in various aquatic organisms.

low

A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.

No genotoxicity observed in a bacterial cell assay. A related substance was not genotoxic in an in vivo assay with mice.

low

A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.

A related substance was not shown to be toxic to reproduction or development in animal tests.

low

A. M. Api, D. C. Liebler, D. O'Brien, A. Patel, T. M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, A. Lapczynski, S. La Cava, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi & S. Tsang. 2019. RIFM fragrance ingredient safety assessment, 3-methyl-2-butenyl acetate, CAS Registry Number 1191-16-8. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134 Suppl 1, 110705.

This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners

low

U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)