developmentb
D

D&C YELLOW NO. 10 (CI 47005)

 
This substance ranges from C to D depending on concentration/usage.
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
Low Concern
 
Developmental &
Reproductive Toxicity
 
Some Concern
 
Cancer
 
No Data, Some Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of damage to DNA; developmental/endocrine/reproductive effects; general systemic/organ effects
D&C Yellow No. 10 (CI 47005) can be found in 10 products.
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Evidence

Health issue
 
Level of Concern
 
Source
EFSA notes there is equivocal evidence of genotoxiciy.
 
some
 
European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
EFSA finds that developmental effects have been observed in animal tests.
 
some
 
European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
A review article reports equivocal evidence of genotoxicity, including in human cell assays.
 
some
 
Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22. - Peer Reviewed Literature
A review article reports equivocal evidence of genotoxicity, including in human cell assays.
 
some
 
Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22. - Peer Reviewed Literature
EFSA concludes there is limited evidence that Yellow 10 in a mixture with other synthetic colours and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population".
 
some
 
European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
A peer-reviewed study reports endocrine activity in cellular assays.
 
some
 
Patrick Tarnow, Catrin Zordick, Alex Bottke, Berit Fischer, Friederike Kühne, Tewes Tralau & Andreas Luch. 2020. Characterization of Quinoline Yellow Dyes As Transient Aryl Hydrocarbon Receptor Agonists. Chemical research in toxicology 33(3), 742-750.
NTP Toxcast scored 1.5-2.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
NTP Toxcast scored 1.5-2.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
SCCS notes there is limited evidence of skin irritation.
 
some
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.
EFSA notes that Yellow 10 intolerance/sensitivity have been reported.
 
some
 
European Food Safety Authority (EFSA). 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
SCCS notes there is limited evidence of eye irritation.
 
low
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.
No evidence of skin sensitization in limited human and animal tests.
 
low
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.
Low acute oral toxicity in animal studies.
 
low
 
European Commission, Scientific Committee on Consumer Safety (SCCS). 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.

Impurities

Health issue
 
Level of Concern
 
Source
Impurity: ZINC
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ZINC
Very toxic to aquatic life with long lasting effects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Suspected of causing genetic defects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Suspected of causing cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Causes damage to organs through prolonged or repeated exposure
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Known to cause cancer
 
some
 
Proposition 65 List (2020 Update) - California OEHHA (Office of Environmental Health Hazard Assessment)
Impurity: CADMIUM
Suspected of causing genetic defects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
May cause cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Causes damage to organs through prolonged or repeated exposure
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Very toxic to aquatic life with long lasting effects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Fatal if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Suspected of damaging fertility.
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Suspected of damaging the unborn child.
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
Carcinogenic to humans
 
some
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Impurity: CADMIUM
Known To Be Human Carcinogen
 
some
 
NTP 14th Report on Carcinogens - National Toxicology Program (NTP)
Impurity: ANILINE
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: ANILINE
Probably carcinogenic to humans
 
some
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Impurity: CADMIUM
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: ANILINE
Toxic if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CADMIUM
kidney damage
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: CADMIUM
suspected human carcinogen
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ZINC
Suspected of damaging fertility or the unborn child
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
suspected of causing genetics defects
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
confirmed animal carcinogen with unknown relevance to humans
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
toxic if inhaled
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Toxic of swallowed
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ZINC
Harmful if swallowed
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ZINC
harmful in inhaled
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ZINC
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ZINC
may cause respiratory irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
may cause respiratory irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ZINC
Causes serious eye damage
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ZINC
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
Causes serious eye damage
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ZINC
causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ANILINE
causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: ZINC
Not classifiable as to human carcinogenicity
 
low
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: ZINC
Not known to cause asthma
 
low
 
AOEC Exposure Code List (2020 Update) - Association of Occupational and Environmental Clinics (AOEC)
Impurity: ZINC COMPOUNDS
Not known to cause asthma
 
low
 
AOEC Exposure Code List (2020 Update) - Association of Occupational and Environmental Clinics (AOEC)
Impurity: ANILINE
Not classifiable as to its carcinogenicity to humans
 
low
 
Agents classified by the IARC Monographs (through Volume 127) - International Agency for Research on Cancer (IARC)
Impurity: ANILINE
EPA testing shows this substance has moderate acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
Impurity: ANILINE
EPA testing shows this substance has low acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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