Health issue
Level of Concern
Source
A review article reports insufficient data to asssess gentoxicity of this substance, but related substances are genotoxic and/or carcinogenic.
some
P. Møller & H. Wallin. 2000. Genotoxic hazards of azo pigments and other colorants related to 1-phenylazo-2-hydroxynaphthalene. Mutation research 462(1), 13-30.
Caused mild skin irritation in animal tests.
some
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
Caused mild skin irritation in animal tests.
some
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
May cause or exacerbate dermatitis.
some
Gabsik Yang, Hye Eun Lee, Kyung-Min Lim, Yong-Kyu Choi, Kyu-Bong Kim, Byung-Mu Lee & Joo Young Lee. 2018. Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. Chemico-biological interactions 284, 41-47.
Caused mild eye irritation in animal tests.
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
Caused mild eye irritation in animal tests.
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
No sensitization observed in animal test.
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
No sensitization observed in animal test.
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
acute toxicity, oral LD50 (mg/kg)
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
acute toxicity, oral LD50 (mg/kg)
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
SCCS concludes this substance has no genotoxic potential.
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
SCCS concludes this substance has no genotoxic potential.
low
Scientific Committee on Consumer Safety (SCCS). 2012. Opinion on Pigment Red 57, COLIPA n° C181. Oct-12 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_112.pdf.
Health issue
Level of Concern
Source
Impurity: ANILINE
Suspected of causing genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Suspected of causing cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Causes damage to organs through prolonged or repeated exposure
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Very toxic to aquatic life
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: CADMIUM
Suspected of causing genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
May cause cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Causes damage to organs through prolonged or repeated exposure
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Very toxic to aquatic life
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Very toxic to aquatic life with long lasting effects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Fatal if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Suspected of damaging fertility.
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Suspected of damaging the unborn child.
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: CADMIUM
Known To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: ANILINE
Probably carcinogenic to humans
some
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
Impurity: ANILINE
Probably carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: CADMIUM
Probably carcinogenic to humans
some
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
Impurity: ANILINE
Toxic if swallowed
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Toxic if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
kidney damage
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: CADMIUM
suspected human carcinogen
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ANILINE
suspected of causing genetics defects
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
confirmed animal carcinogen with unknown relevance to humans
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
toxic if inhaled
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Toxic of swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Not classifiable as to its carcinogenicity to humans
low
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: ANILINE
EPA testing shows this substance has moderate acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
Impurity: ANILINE
EPA testing shows this substance has low acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database