Evidence
Health issue
Level of Concern
Source
In vivo and in vitro testing found no evidence of genotoxicity.
some
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Categorised as possible contact allergen.
some
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
Impacts on liver enzyme function observed in rats.
some
Hye Gwang Jeong, Young-Jin Chun, Chul-Ho Yun, Chang-Kiu Moon, Hye-Sook Lee, Sang Seop Han, Eung-Seok Lee & Tae Cheon Jeong. 2002. Induction of cytochrome P450 1A and 2B by alpha- and beta-ionone in Sprague Dawley rats. Archives of pharmacal research 25(2), 197-201.
Human and animal testing found no evidence of skin sensitization.
low
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
Animal testing shows no evidence of developmental or reproductive toxicity.
low
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
