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IONONE, ALPHA-

 
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
Low Concern
 
Cancer
 
No Data, Some Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: No information available on this substance.
IONONE, ALPHA- can be found in 146 products.
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Evidence

Health issue
 
Level of Concern
 
Source
In vivo and in vitro testing found no evidence of genotoxicity.
 
some
 
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
NTP Toxcast scored 2.5-3.5
 
some
 
National Toxicology Program (NTP): EWG Toxcast Analysis
Categorised as possible contact allergen.
 
some
 
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
Impacts on liver enzyme function observed in rats.
 
some
 
Hye Gwang Jeong, Young-Jin Chun, Chul-Ho Yun, Chang-Kiu Moon, Hye-Sook Lee, Sang Seop Han, Eung-Seok Lee & Tae Cheon Jeong. 2002. Induction of cytochrome P450 1A and 2B by alpha- and beta-ionone in Sprague Dawley rats. Archives of pharmacal research 25(2), 197-201.
Human and animal testing found no evidence of skin sensitization.
 
low
 
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
Animal testing shows no evidence of developmental or reproductive toxicity.
 
low
 
A. M. Api, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. Wall, A. Lapczynski, J. F. Lalko, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava & D. K. Wilcox. 2016. RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97S, S1-S10.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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