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HOME / INGREDIENTS / Solvent yellow 33 (uncertified d&c yellow no. 11)


D

Solvent Yellow 33 (Uncertified D&C Yellow No. 11)

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COMMONLY FOUND IN


SYNONYMS

SOLVENT YELLOW 33 (UNCERTIFIED D&C YELLOW NO. 11), C.I. SOLVENT YELLOW 33, SOLVENT YELLOW 33


RESTRICTED

EWG VERIFIED products cannot contain this ingredient without adequate substantiation.

Common Concerns

See how this product scores for common concerns.

  • No Data
    Asthma / Respiratory
  • SOME
    Skin Allergies & Irritation
  • SOME
    Developmental & Reproductive Toxicity
  • SOME
    Cancer
  • No Data
    Environment


Top Scoring Factors

Evidence of damage to DNA; developmental/endocrine/reproductive effects; skin irritation/allergies/damage


Ingredient concerns

  • CONCERNS
Health Issue Level of Concern Source
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Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

May damage the unborn child.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

peripheral nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

kidney damage

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

central nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

The National Toxicology Program concluded there is some evidence that this substance is carcinogenic based on animal testing.

some

William Eastin. 1991. NTP technical report on the toxicity studies of D&C Yellow No. 11 in F344/N Rats and B6C3F1 Mice (Feed Studies) (CAS No. 8003-22-3). Toxicity report series 8, 1-32.

The National Toxicology Program reports evidence this substance may have developmental effects.

some

William Eastin. 1991. NTP technical report on the toxicity studies of D&C Yellow No. 11 in F344/N Rats and B6C3F1 Mice (Feed Studies) (CAS No. 8003-22-3). Toxicity report series 8, 1-32.

A peer-reviewed study reports endocrine activity in cellular assays.

some

Patrick Tarnow, Catrin Zordick, Alex Bottke, Berit Fischer, Friederike Kühne, Tewes Tralau & Andreas Luch. 2020. Characterization of Quinoline Yellow Dyes As Transient Aryl Hydrocarbon Receptor Agonists. Chemical research in toxicology 33(3), 742-750.

A peer-reviewed study reports evidence that this substance may interfere with DNA repair.

some

Farah Md Chequer, Vinicius P. Venancio, Mara R. Almeida, Alexandre F. Aissa, Maria Lourdes P. Bianchi & Lusânia Mg Antunes. 2017. Erythrosine B and quinoline yellow dyes regulate DNA repair gene expression in human HepG2 cells. Toxicology and industrial health 33(10), 765-774.

A peer-reviewed study reports in vitro genotoxicity.

some

Farah Maria Drumond Chequer, Vinícius de Paula Venâncio, Maíra Rocha de Souza Prado, Luiz Raimundo Campos da Silva e Cunha Junior, Thiago Mescoloto Lizier, Maria Valnice Boldrin Zanoni, Rommel Rodríguez Burbano, Maria Lourdes Pires Bianchi & Lusânia Maria Greggi Antunes. 2015. The cosmetic dye quinoline yellow causes DNA damage in vitro. Mutation research. Genetic toxicology and environmental mutagenesis 777, 54-61.

May cause an allergic skin reaction

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

May cause an allergic skin reaction

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause cancer

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause cancer

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Known to cause reproductive toxicity (to females)

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Known to cause reproductive toxicity (to males)

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Known to cause reproductive toxicity

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Very toxic to aquatic life

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Very toxic to aquatic life with long lasting effects

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

May damage the unborn child.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Suspected of damaging fertility.

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

Known To Be Human Carcinogen

some

National Toxicology Program (NTP): NTP 14th Report on Carcinogens

The Agency for Toxic Substances and Disease Registry reports this substance damages the cardiovascular system.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

The Agency for Toxic Substances and Disease Registry reports this substance damages the immune system.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

The Agency for Toxic Substances and Disease Registry reports this substance causes damage to the skin.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

The Agency for Toxic Substances and Disease Registry reports this substance can damage the kidneys.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

Causes damage to organs through prolonged or repeated exposure

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Fatal if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Probably carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

Reasonably Anticipated To Be Human Carcinogen

some

National Toxicology Program (NTP): NTP 14th Report on Carcinogens

Toxic if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

peripheral nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

hematologic effects

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

confirmed human carcinogen

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

cancer

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

lung cancer

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

kidney damage

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

central nervous system impairment

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

EPA's review of industry submitted toxicity data and the potential for human exposure concludes that this substance poses a high risk for human health.

some

Environmental Protection Agency (EPA): EPA Hazard-Based Prioritizations - Risks

Harmful if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Harmful if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

harmful in inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Possibly carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

May cause damage to organs through prolonged or repeated exposure

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Harmful if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Harmful if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

The Agency for Toxic Substances and Disease Registry reports this substance shows some evidence of damage to the developing fetus.

some

U.S. Department of Health and Human Services - Agency for Toxic Substances and Disease Registry. 2007. Toxicological Profile for Arsenic.

A peer-reviewed study reports evidence of dermal sensitization from animal testing.

some

M. J. Palazzolo & L. C. DiPasquale. 1983. The sensitization potential of D & C Yellow No. 11 in guinea pigs. Contact dermatitis 9(5), 367-71.

Allergic contact dermatitis reported in humans following occupational exposure.

some

K. Matsunaga, K. Hosokawa, M. Suzuki, Y. Arima & R. Hayakawa. 1988. Occupational allergic contact dermatitis in beauticians. Contact dermatitis 18(2), 94-6.

A peer-reviewed article reports evidence of dermal sensitization from human testing.

some

S. Kita, T. Kobayashi, H. Kutsuna & A. M. Kligman. 1984. Human maximization testing of D&C Yellow no. 10 and Yellow no. 11. Contact dermatitis 11(4), 210-3.

may cause cancer

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause harm to breast-fed children

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may damage fertility or the unborn child

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes damage to organs through prolonged or repeated exposure

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Fatal if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

fatal if inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

confirmed animal carcinogen with unknown relevance to humans

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

A peer-reviewed study reports of evidence of kidney and liver effects at high doses in animal testing.

some

W. C. Eastin, M. R. Elwell, S. Grumbein & J. H. Yuan. 1996. Effects of D&C yellow no. 11 ingestion on F344/N rats and B6C3F1 mice. Journal of toxicology and environmental health 48(2), 197-213.

Harmful if swallowed

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Harmful in contact with skin

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

harmful in inhaled

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause damage to organs through prolonged or repeated exposure

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause drowsiness or dizziness

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

may cause respiratory irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes skin irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Causes serious eye damage

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Not classifiable as to its carcinogenicity to humans

low

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Not classifiable as to human carcinogenicity

low

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

not classifiable as a human carcinogen

low

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis



Understanding scores

EWG provides information on cleaning product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.

HOW WE DETERMINE SCORES

Hazard score

The Healthy Cleaning ingredient hazard score, from A to F, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend


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