Evidence
Health issue
Level of Concern
Source
Clear evidence of endocrine disruption in at least one animal study
high
EU Endocrine: EU Endocrine Disrupters
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high acute aquatic toxicity.
high
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high chronic aquatic toxicity.
high
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to be persistent in the environment, especially under anaerobic conditions.
high
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high acute aquatic toxicity.
moderate
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high chronic aquatic toxicity.
moderate
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Harmful if swallowed
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
may cause respiratory irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
May cause an allergic skin reaction
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Harmful if swallowed
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes serious eye damage
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
causes serious eye irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurities
Health issue
Level of Concern
Source
Impurity: PHENOL, P-NONYL-
Clear evidence of endocrine disruption in at least one animal study
Clear evidence of endocrine disruption in at least one animal study
some
EU Endocrine: EU Endocrine Disrupters
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high acute aquatic toxicity.
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high acute aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high chronic aquatic toxicity.
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high chronic aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to be persistent in the environment, especially under anaerobic conditions.
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to be persistent in the environment, especially under anaerobic conditions.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: ETHYLENE OXIDE
May cause genetic defects
May cause genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
May cause cancer
May cause cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Known to cause cancer
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to females)
Known to cause reproductive toxicity (to females)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to males)
Known to cause reproductive toxicity (to males)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity
Known to cause reproductive toxicity
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Carcinogenic to humans
Carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: ETHYLENE OXIDE
Known To Be Human Carcinogen
Known To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: 1,4-DIOXANE
Suspected of causing cancer
Suspected of causing cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
Known to cause cancer
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: 1,4-DIOXANE
Reasonably Anticipated To Be Human Carcinogen
Reasonably Anticipated To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: ETHYLENE OXIDE
Toxic if inhaled
Only in: Household Cleaners
Toxic if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes pulmonary edema
Causes pulmonary edema
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes skin corrosion
Only in: Oven Cleaner; Drain Opener/Clog Remover
Causes skin corrosion
Only in: Oven Cleaner; Drain Opener/Clog Remover
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes reproductive effects
Causes reproductive effects
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes leukemia
Causes leukemia
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes peritoneal cancer
Causes peritoneal cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
cancer
cancer
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
central nervous system impairment
central nervous system impairment
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
Asthmagen (irritation)
Asthmagen (irritation)
some
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
Impurity: 1,4-DIOXANE
Causes cancer
Causes cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
liver damage
liver damage
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
suspected human carcinogen
suspected human carcinogen
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high acute aquatic toxicity.
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high acute aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high chronic aquatic toxicity.
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high chronic aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: 1,4-DIOXANE
Possibly carcinogenic to humans
Possibly carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: PHENOL, P-NONYL-
EPA testing shows this substance has high acute toxicity to aquatic life
EPA testing shows this substance has high acute toxicity to aquatic life
some
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
Impurity: PHENOL, P-NONYL-
Suspected of damaging fertility or the unborn child
Only in: Household Cleaners
Suspected of damaging fertility or the unborn child
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: PHENOL, P-NONYL-
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: 1,4-DIOXANE
confirmed animal carcinogen with unknown relevance to humans
confirmed animal carcinogen with unknown relevance to humans
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
May cause respiratory irritation
Only in: Household Cleaners
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
May cause respiratory irritation
Only in: Household Cleaners
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes respiratory irritation
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
Causes respiratory irritation
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: PHENOL, P-NONYL-
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: PHENOL, P-NONYL-
NTP Toxcast scored 2.5-3.5
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Impurity: ETHYLENE OXIDE
Causes skin irritation
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes eye corrosion
Only in: Drain Opener/Clog Remover; Oven Cleaner
Causes eye corrosion
Only in: Drain Opener/Clog Remover; Oven Cleaner
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
Causes skin irritation
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
may cause respiratory irritation
Only in: Household Cleaners
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes serious eye irritation
Only in: Household Cleaners
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
Causes serious eye irritation
Only in: Household Cleaners
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: PHENOL, P-NONYL-
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: PHENOL, P-NONYL-
Causes serious eye damage
Only in: Household Cleaners
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes serious eye damage
Only in: Household Cleaners
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
causes serious eye irritation
Only in: Household Cleaners
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
Impurity: 1,4-DIOXANE
EPA testing shows this substance has low acute toxicity to aquatic life
EPA testing shows this substance has low acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
