Health issue
Level of Concern
Source
Impurity: PHENOL, P-NONYL-
Clear evidence of endocrine disruption in at least one animal study
some
EU Endocrine: EU Endocrine Disrupters
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high acute aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to possess very high chronic aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found 4-nonylphenol to be persistent in the environment, especially under anaerobic conditions.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: ETHYLENE OXIDE
May cause genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
May cause cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to females)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to males)
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: ETHYLENE OXIDE
Carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: ETHYLENE OXIDE
Known To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: 1,4-DIOXANE
Suspected of causing cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: 1,4-DIOXANE
Reasonably Anticipated To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: ETHYLENE OXIDE
Toxic if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes pulmonary edema
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes skin corrosion
Only in: Oven Cleaner; Drain Opener/Clog Remover
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes reproductive effects
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes leukemia
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes peritoneal cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
cancer
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
central nervous system impairment
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
Asthmagen (irritation)
some
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
Impurity: 1,4-DIOXANE
Causes cancer
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
liver damage
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
suspected human carcinogen
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high acute aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: PHENOL, P-NONYL-
A U.S. Environmental Protection Agency alternatives assessment found nonylphenol ethoxylates have high chronic aquatic toxicity.
some
U.S. Environmental Protection Agency (EPA). 2012. DfE Alternatives Assessment for Nonylphenol Ethoxylates.
Impurity: 1,4-DIOXANE
Possibly carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: PHENOL, P-NONYL-
EPA testing shows this substance has high acute toxicity to aquatic life
some
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
Impurity: PHENOL, P-NONYL-
Suspected of damaging fertility or the unborn child
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: PHENOL, P-NONYL-
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: 1,4-DIOXANE
confirmed animal carcinogen with unknown relevance to humans
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ETHYLENE OXIDE
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
May cause respiratory irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ETHYLENE OXIDE
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
Causes respiratory irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: PHENOL, P-NONYL-
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: PHENOL, P-NONYL-
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Impurity: ETHYLENE OXIDE
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
Causes eye corrosion
Only in: Drain Opener/Clog Remover; Oven Cleaner
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: 1,4-DIOXANE
Causes skin irritation
some
Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards
Impurity: ETHYLENE OXIDE
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: 1,4-DIOXANE
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: PHENOL, P-NONYL-
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: PHENOL, P-NONYL-
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ETHYLENE OXIDE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
Impurity: 1,4-DIOXANE
EPA testing shows this substance has low acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database