Evidence
Health issue
Level of Concern
Source
A review article reports that this substance can be transformed into carcinogenic metabolites, including by the human skin and gut microbiomes.
some
Teresa M. Fonovich. 2013. Sudan dyes: are they dangerous for human health?. Drug and chemical toxicology 36(3), 343-52.
This substance disrupts endocrine receptor expression in vivo.
some
Zein Shaban, Samir El-Shazly, Shawky Abdelhady, Ibrahim Fattouh, Kaampwe Muzandu, Mayumi Ishizuka, Kazuhiro Kimura, Akio Kazusaka & Shoichi Fujita. 2004. Down regulation of hepatic PPARalpha function by AhR ligand. The Journal of veterinary medical science 66(11), 1377-86.
may cause respiratory irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Substance disrupts function of liver enzymes.
some
European Commission, Scientific Committee on Consumer Products (SCCP). 2005. Opinion on the use of CI 26100 (CI Solvent Red 23) as a colorant in cosmetic products.
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes serious eye damage
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Substances has marginal irritant properties to skin and mucous membranes.
some
European Commission, Scientific Committee on Consumer Products (SCCP). 2005. Opinion on the use of CI 26100 (CI Solvent Red 23) as a colorant in cosmetic products.
Not classifiable as to its carcinogenicity to humans
low
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Not classifiable as to its carcinogenicity to humans
low
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Studies of carcinogenic potential to date have been inadequate.
low
European Commission, Scientific Committee on Consumer Products (SCCP). 2005. Opinion on the use of CI 26100 (CI Solvent Red 23) as a colorant in cosmetic products.
Low acute oral toxicity.
low
European Commission, Scientific Committee on Consumer Products (SCCP). 2005. Opinion on the use of CI 26100 (CI Solvent Red 23) as a colorant in cosmetic products.
Impurities
Health issue
Level of Concern
Source
Impurity: P-PHENYLENEDIAMINE
Very toxic to aquatic life
Very toxic to aquatic life
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: P-PHENYLENEDIAMINE
Very toxic to aquatic life with long lasting effects
Very toxic to aquatic life with long lasting effects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: P-PHENYLENEDIAMINE
Toxic if swallowed
Only in: Household Cleaners
Toxic if swallowed
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: P-PHENYLENEDIAMINE
Toxic in contact with skin
Only in: Household Cleaners
Toxic in contact with skin
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: P-PHENYLENEDIAMINE
Toxic if inhaled
Only in: Household Cleaners
Toxic if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: P-PHENYLENEDIAMINE
causes damage to organs
Only in: Household Cleaners
causes damage to organs
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: P-PHENYLENEDIAMINE
May cause an allergic skin reaction
Only in: Household Cleaners
May cause an allergic skin reaction
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: P-PHENYLENEDIAMINE
skin sensitization
skin sensitization
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: P-PHENYLENEDIAMINE
upper respiratory tract irritation
upper respiratory tract irritation
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: P-PHENYLENEDIAMINE
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: P-PHENYLENEDIAMINE
May cause an allergic skin reaction
Only in: Household Cleaners
May cause an allergic skin reaction
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: P-PHENYLENEDIAMINE
Causes serious eye irritation
Only in: Household Cleaners
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: P-PHENYLENEDIAMINE
NTP Toxcast scored 1.5-2.5
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Impurity: P-PHENYLENEDIAMINE
Not classifiable as to its carcinogenicity to humans
Not classifiable as to its carcinogenicity to humans
low
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: P-PHENYLENEDIAMINE
not classifiable as a human carcinogen
not classifiable as a human carcinogen
low
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: P-PHENYLENEDIAMINE
Not known to cause asthma
Not known to cause asthma
low
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
