Evidence
Health issue
Level of Concern
Source
May cause an allergic skin reaction
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
Impurities
Health issue
Level of Concern
Source
Impurity: METHYLPARABEN
Clear evidence of endocrine disruption in at least one animal study
Clear evidence of endocrine disruption in at least one animal study
some
EU Endocrine: EU Endocrine Disrupters
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
some
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: TRICLOSAN
Asthmagen (sensitizing)
Asthmagen (sensitizing)
some
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
Impurity: TRICLOSAN
Very toxic to aquatic life
Very toxic to aquatic life
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: TRICLOSAN
Very toxic to aquatic life with long lasting effects
Very toxic to aquatic life with long lasting effects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: TRICLOSAN
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: TRICLOSAN
Asthmagen (sensitizing)
Asthmagen (sensitizing)
some
Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)
Impurity: BENZETHONIUM CHLORIDE
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
some
EU Ecolabel: Detergents Ingredients Database
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
some
EU Ecolabel: Detergents Ingredients Database
Impurity: TRICLOSAN
This review article reports triclosan can act as an endocrine disruptor
This review article reports triclosan can act as an endocrine disruptor
some
Andrea B. Dann & Alice Hontela. 2011. Triclosan: environmental exposure, toxicity and mechanisms of action. Journal of applied toxicology : JAT 31(4), 285-311.
Impurity: TRICLOSAN
risk of promoting bacterial resistance
risk of promoting bacterial resistance
some
Gilles Bedoux, Benoit Roig, Olivier Thomas, Virginie Dupont & Barbara Le Bot. 2012. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environmental science and pollution research international 19(4), 1044-65.
Impurity: TRICLOSAN
risk of developing antimicrobial-resistant bacteria
risk of developing antimicrobial-resistant bacteria
some
Allison E. Aiello, Elaine L. Larson & Stuart B. Levy. 2007. Consumer antibacterial soaps: effective or just risky?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45 Suppl 2, S137-47.
Impurity: BENZETHONIUM CHLORIDE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is not anaerobically degradable.
The European Union Ecolabel program reports this substance is not anaerobically degradable.
some
EU Ecolabel: Detergents Ingredients Database
Impurity: BENZETHONIUM CHLORIDE
Toxic of swallowed
Only in: Household Cleaners
Toxic of swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: METHYLPARABEN
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: TRICLOSAN
alters endocrine function in a variety of species
alters endocrine function in a variety of species
some
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: TRICLOSAN
alters endocrine function in a variety of species
alters endocrine function in a variety of species
some
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: TRICLOSAN
decreases thyroid hormone levels
decreases thyroid hormone levels
some
Katie B. Paul, Joan M. Hedge, Ruby Bansal, R. Thomas Zoeller, Robert Peter, Michael J. Devito & Kevin M. Crofton. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: Dynamic and kinetic evaluation of a putative mode-of-action. Toxicology.
Impurity: TRICLOSAN
decreases thyroid hormone levels
decreases thyroid hormone levels
some
Katie B. Paul, Joan M. Hedge, Michael J. Devito & Kevin M. Crofton. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. Toxicological sciences : an official journal of the Society of Toxicology 113(2), 367-79.
Impurity: TRICLOSAN
Triclosan may negatively affect immune function in people
Triclosan may negatively affect immune function in people
some
Erin M. Rees Clayton, Megan Todd, Jennifer Beam Dowd & Allison E. Aiello. 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental health perspectives 119(3), 390-6.
Impurity: TRICLOSAN
triclosan affected estrogen-mediated responses and suppressed thyroid hormone
triclosan affected estrogen-mediated responses and suppressed thyroid hormone
some
Tammy E. Stoker, Emily K. Gibson & Leah M. Zorrilla. 2010. Triclosan exposure modulates estrogen-dependent responses in the female wistar rat. Toxicological sciences : an official journal of the Society of Toxicology 117(1), 45-53.
Impurity: TRICLOSAN
A peer-reviewed study reports that triclosan impairs cardiac and skeletal muscle function.
A peer-reviewed study reports that triclosan impairs cardiac and skeletal muscle function.
some
Gennady Cherednichenko, Nipavan Chiamvimonvat, Kurt G. Beam, Bruce D. Hammock, Nils H. Schebb, Genaro C. Barrientos, Wei Feng, Erika B. Fritsch, Ning Li, Valeriy Timofeyev, Roger A. Bannister, Rui Zhang & Isaac N. Pessah. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35), 14158-63.
Impurity: TRICLOSAN
NTP Toxcast scored 2.5-3.5
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Impurity: METHYLPARABEN
causes serious eye irritation
Only in: Household Cleaners
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: METHYLPARABEN
may cause respiratory irritation
Only in: Household Cleaners
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: TRICLOSAN
Causes serious eye irritation
Only in: Household Cleaners
Causes serious eye irritation
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: METHYLPARABEN
NTP Toxcast scored 1.5-2.5
NTP Toxcast scored 1.5-2.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Impurity: BENZETHONIUM CHLORIDE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: BENZETHONIUM CHLORIDE
Causes serious eye damage
Only in: Household Cleaners
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: METHYLPARABEN
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
low
EU Ecolabel: Detergents Ingredients Database
Impurity: TRICLOSAN
The European Union Ecolabel program reports this substance in inherently biodegradable.
The European Union Ecolabel program reports this substance in inherently biodegradable.
low
EU Ecolabel: Detergents Ingredients Database
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is readily biodegradable.
The European Union Ecolabel program reports this substance is readily biodegradable.
low
EU Ecolabel: Detergents Ingredients Database
Impurity: METHYLPARABEN
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
low
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
