Evidence
Health issue
Level of Concern
Source
May cause an allergic skin reaction
Only in: Household Cleaners
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Causes skin irritation
Only in: Household Cleaners
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
some
CIR Assessments - Cosmetic Ingredient Review (CIR)
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.
some
CIR Assessments - Cosmetic Ingredient Review (CIR)
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
Only in: Household Cleaners
low
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
Impurities
Health issue
Level of Concern
Source
Impurity: METHYLPARABEN
Clear evidence of endocrine disruption in at least one animal study
Clear evidence of endocrine disruption in at least one animal study
some
EU Endocrine Disrupters - EU Endocrine
Impurity: PARABENS, FOOD
The European Food Safety Authority reports this substance causes reproductive effects in animals.
Only in: Food Scores®
The European Food Safety Authority reports this substance causes reproductive effects in animals.
Only in: Food Scores®
some
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
Impurity: TRICLOSAN
Very toxic to aquatic life
Very toxic to aquatic life
some
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: TRICLOSAN
Very toxic to aquatic life with long lasting effects
Very toxic to aquatic life with long lasting effects
some
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: PARABENS
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
some
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: TRICLOSAN
Asthmagen (sensitizing)
Asthmagen (sensitizing)
some
AOEC Exposure Code List (2020 Update) - Association of Occupational and Environmental Clinics (AOEC)
Impurity: PARABENS, FOOD
The European Food Safety Authority reports this substance causes hyperplasia in animals at high doses.
The European Food Safety Authority reports this substance causes hyperplasia in animals at high doses.
some
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
some
Detergents Ingredients Database - EU Ecolabel
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
some
Detergents Ingredients Database - EU Ecolabel
Impurity: BENZETHONIUM CHLORIDE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is not anaerobically degradable.
The European Union Ecolabel program reports this substance is not anaerobically degradable.
some
Detergents Ingredients Database - EU Ecolabel
Impurity: BENZETHONIUM CHLORIDE
Toxic of swallowed
Only in: Household Cleaners
Toxic of swallowed
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: QUATERNARY AMMONIUM COMPOUNDS
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
some
Vanessa E. Melin, Travis E. Melin, Brian J. Dessify, Christina T. Nguyen, Caroline S. Shea & Terry C. Hrubec. 2015. Quaternary Ammonium Disinfectants Cause Subfertility in Mice by Targeting both Male and Female Reproductive Processes. Reproductive toxicology (Elmsford, N.Y.).
Impurity: QUATERNARY AMMONIUM COMPOUNDS
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
some
Vanessa E. Melin, Haritha Potineni, Patricia Hunt, Jodi Griswold, Bill Siems, Stephen R. Werre & Terry C. Hrubec. 2014. Exposure to common quaternary ammonium disinfectants decreases fertility in mice. Reproductive toxicology (Elmsford, N.Y.) 50, 163-70.
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
some
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: TRICLOSAN
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: BENZETHONIUM CHLORIDE
Harmful if swallowed
Only in: Household Cleaners
Harmful if swallowed
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: TRICLOSAN
NTP Toxcast scored 2.5-3.5
NTP Toxcast scored 2.5-3.5
some
EWG Toxcast Analysis - National Toxicology Program (NTP)
Impurity: TRICLOSAN
This review article reports triclosan can act as an endocrine disruptor
This review article reports triclosan can act as an endocrine disruptor
some
Andrea B. Dann & Alice Hontela. 2011. Triclosan: environmental exposure, toxicity and mechanisms of action. Journal of applied toxicology : JAT 31(4), 285-311.
Impurity: TRICLOSAN
risk of promoting bacterial resistance
risk of promoting bacterial resistance
some
Gilles Bedoux, Benoit Roig, Olivier Thomas, Virginie Dupont & Barbara Le Bot. 2012. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environmental science and pollution research international 19(4), 1044-65.
Impurity: TRICLOSAN
risk of developing antimicrobial-resistant bacteria
risk of developing antimicrobial-resistant bacteria
some
Allison E. Aiello, Elaine L. Larson & Stuart B. Levy. 2007. Consumer antibacterial soaps: effective or just risky?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45 Suppl 2, S137-47.
Impurity: METHYLPARABEN
may cause respiratory irritation
Only in: Household Cleaners
may cause respiratory irritation
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: TRICLOSAN
Causes serious eye irritation
Only in: Household Cleaners
Causes serious eye irritation
Only in: Household Cleaners
some
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: METHYLPARABEN
NTP Toxcast scored 1.5-2.5
NTP Toxcast scored 1.5-2.5
some
EWG Toxcast Analysis - National Toxicology Program (NTP)
Impurity: BENZETHONIUM CHLORIDE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: BENZETHONIUM CHLORIDE
Causes serious eye damage
Only in: Household Cleaners
Causes serious eye damage
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: METHYLPARABEN
Causes skin irritation
Only in: Household Cleaners
Causes skin irritation
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: TRICLOSAN
alters endocrine function in a variety of species
alters endocrine function in a variety of species
some
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: TRICLOSAN
alters endocrine function in a variety of species
alters endocrine function in a variety of species
some
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: TRICLOSAN
decreases thyroid hormone levels
decreases thyroid hormone levels
some
Katie B. Paul, Joan M. Hedge, Ruby Bansal, R. Thomas Zoeller, Robert Peter, Michael J. Devito & Kevin M. Crofton. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: Dynamic and kinetic evaluation of a putative mode-of-action. Toxicology.
Impurity: TRICLOSAN
decreases thyroid hormone levels
decreases thyroid hormone levels
some
Katie B. Paul, Joan M. Hedge, Michael J. Devito & Kevin M. Crofton. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. Toxicological sciences : an official journal of the Society of Toxicology 113(2), 367-79.
Impurity: TRICLOSAN
Triclosan may negatively affect immune function in people
Triclosan may negatively affect immune function in people
some
Erin M. Rees Clayton, Megan Todd, Jennifer Beam Dowd & Allison E. Aiello. 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental health perspectives 119(3), 390-6.
Impurity: TRICLOSAN
triclosan affected estrogen-mediated responses and suppressed thyroid hormone
triclosan affected estrogen-mediated responses and suppressed thyroid hormone
some
Tammy E. Stoker, Emily K. Gibson & Leah M. Zorrilla. 2010. Triclosan exposure modulates estrogen-dependent responses in the female wistar rat. Toxicological sciences : an official journal of the Society of Toxicology 117(1), 45-53.
Impurity: TRICLOSAN
A peer-reviewed study reports that triclosan impairs cardiac and skeletal muscle function.
A peer-reviewed study reports that triclosan impairs cardiac and skeletal muscle function.
some
Gennady Cherednichenko, Nipavan Chiamvimonvat, Kurt G. Beam, Bruce D. Hammock, Nils H. Schebb, Genaro C. Barrientos, Wei Feng, Erika B. Fritsch, Ning Li, Valeriy Timofeyev, Roger A. Bannister, Rui Zhang & Isaac N. Pessah. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35), 14158-63.
Impurity: METHYLPARABEN
causes serious eye irritation
Only in: Household Cleaners
causes serious eye irritation
Only in: Household Cleaners
some
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: METHYLPARABEN
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
low
Detergents Ingredients Database - EU Ecolabel
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
low
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: TRICLOSAN
The European Union Ecolabel program reports this substance in inherently biodegradable.
The European Union Ecolabel program reports this substance in inherently biodegradable.
low
Detergents Ingredients Database - EU Ecolabel
Impurity: METHYLPARABEN
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is readily biodegradable.
The European Union Ecolabel program reports this substance is readily biodegradable.
low
Detergents Ingredients Database - EU Ecolabel
Impurity: PARABENS
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
low
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: PARABENS, FOOD
The European Food Safety Authority reports this substance is not gentoxic
Only in: Food Scores®
The European Food Safety Authority reports this substance is not gentoxic
Only in: Food Scores®
low
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
