developmentb
D

CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT

 
This substance ranges from C to D depending on concentration/usage.
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
No Data, Some Concern
 
Cancer
 
No Data, Some Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of skin irritation/allergies/damage; chronic aquatic toxicity; respiratory effects
CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT can be found in 26 products.
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Evidence

Health issue
 
Level of Concern
 
Source
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
 
some
 
CIR Assessments - Cosmetic Ingredient Review (CIR)
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.
 
some
 
CIR Assessments - Cosmetic Ingredient Review (CIR)
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)

Impurities

Health issue
 
Level of Concern
 
Source
Impurity: METHYLPARABEN
Clear evidence of endocrine disruption in at least one animal study
 
some
 
EU Endocrine Disrupters - EU Endocrine
Impurity: PARABENS, FOOD
The European Food Safety Authority reports this substance causes reproductive effects in animals.
Only in: Food Scores®
 
some
 
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
Impurity: TRICLOSAN
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: TRICLOSAN
Very toxic to aquatic life with long lasting effects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: PARABENS
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
 
some
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: TRICLOSAN
Asthmagen (sensitizing)
 
some
 
AOEC Exposure Code List (2020 Update) - Association of Occupational and Environmental Clinics (AOEC)
Impurity: PARABENS, FOOD
The European Food Safety Authority reports this substance causes hyperplasia in animals at high doses.
 
some
 
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
 
some
 
Detergents Ingredients Database - EU Ecolabel
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
 
some
 
Detergents Ingredients Database - EU Ecolabel
Impurity: BENZETHONIUM CHLORIDE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is not anaerobically degradable.
 
some
 
Detergents Ingredients Database - EU Ecolabel
Impurity: BENZETHONIUM CHLORIDE
Toxic of swallowed
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: QUATERNARY AMMONIUM COMPOUNDS
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
 
some
 
Vanessa E. Melin, Travis E. Melin, Brian J. Dessify, Christina T. Nguyen, Caroline S. Shea & Terry C. Hrubec. 2015. Quaternary Ammonium Disinfectants Cause Subfertility in Mice by Targeting both Male and Female Reproductive Processes. Reproductive toxicology (Elmsford, N.Y.).
Impurity: QUATERNARY AMMONIUM COMPOUNDS
A peer-reviewed publication reports some quaternary ammonium compounds cause reproductive toxicity in animals.
 
some
 
Vanessa E. Melin, Haritha Potineni, Patricia Hunt, Jodi Griswold, Bill Siems, Stephen R. Werre & Terry C. Hrubec. 2014. Exposure to common quaternary ammonium disinfectants decreases fertility in mice. Reproductive toxicology (Elmsford, N.Y.) 50, 163-70.
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
 
some
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: TRICLOSAN
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: BENZETHONIUM CHLORIDE
Harmful if swallowed
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: TRICLOSAN
NTP Toxcast scored 2.5-3.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Impurity: TRICLOSAN
This review article reports triclosan can act as an endocrine disruptor
 
some
 
Andrea B. Dann & Alice Hontela. 2011. Triclosan: environmental exposure, toxicity and mechanisms of action. Journal of applied toxicology : JAT 31(4), 285-311.
Impurity: TRICLOSAN
risk of promoting bacterial resistance
 
some
 
Gilles Bedoux, Benoit Roig, Olivier Thomas, Virginie Dupont & Barbara Le Bot. 2012. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environmental science and pollution research international 19(4), 1044-65.
Impurity: TRICLOSAN
risk of developing antimicrobial-resistant bacteria
 
some
 
Allison E. Aiello, Elaine L. Larson & Stuart B. Levy. 2007. Consumer antibacterial soaps: effective or just risky?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45 Suppl 2, S137-47.
Impurity: METHYLPARABEN
may cause respiratory irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: TRICLOSAN
Causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: METHYLPARABEN
NTP Toxcast scored 1.5-2.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Impurity: BENZETHONIUM CHLORIDE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: BENZETHONIUM CHLORIDE
Causes serious eye damage
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: METHYLPARABEN
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: TRICLOSAN
alters endocrine function in a variety of species
 
some
 
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: TRICLOSAN
alters endocrine function in a variety of species
 
some
 
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: TRICLOSAN
decreases thyroid hormone levels
 
some
 
Katie B. Paul, Joan M. Hedge, Ruby Bansal, R. Thomas Zoeller, Robert Peter, Michael J. Devito & Kevin M. Crofton. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: Dynamic and kinetic evaluation of a putative mode-of-action. Toxicology.
Impurity: TRICLOSAN
decreases thyroid hormone levels
 
some
 
Katie B. Paul, Joan M. Hedge, Michael J. Devito & Kevin M. Crofton. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. Toxicological sciences : an official journal of the Society of Toxicology 113(2), 367-79.
Impurity: TRICLOSAN
Triclosan may negatively affect immune function in people
 
some
 
Erin M. Rees Clayton, Megan Todd, Jennifer Beam Dowd & Allison E. Aiello. 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental health perspectives 119(3), 390-6.
Impurity: TRICLOSAN
triclosan affected estrogen-mediated responses and suppressed thyroid hormone
 
some
 
Tammy E. Stoker, Emily K. Gibson & Leah M. Zorrilla. 2010. Triclosan exposure modulates estrogen-dependent responses in the female wistar rat. Toxicological sciences : an official journal of the Society of Toxicology 117(1), 45-53.
Impurity: TRICLOSAN
A peer-reviewed study reports that triclosan impairs cardiac and skeletal muscle function.
 
some
 
Gennady Cherednichenko, Nipavan Chiamvimonvat, Kurt G. Beam, Bruce D. Hammock, Nils H. Schebb, Genaro C. Barrientos, Wei Feng, Erika B. Fritsch, Ning Li, Valeriy Timofeyev, Roger A. Bannister, Rui Zhang & Isaac N. Pessah. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35), 14158-63.
Impurity: METHYLPARABEN
causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Data from ECHA Website - European Chemicals Agency (ECHA)
Impurity: METHYLPARABEN
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
 
low
 
Detergents Ingredients Database - EU Ecolabel
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
 
low
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: TRICLOSAN
The European Union Ecolabel program reports this substance in inherently biodegradable.
 
low
 
Detergents Ingredients Database - EU Ecolabel
Impurity: METHYLPARABEN
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is readily biodegradable.
 
low
 
Detergents Ingredients Database - EU Ecolabel
Impurity: PARABENS
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
 
low
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: PARABENS, FOOD
The European Food Safety Authority reports this substance is not gentoxic
Only in: Food Scores®
 
low
 
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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