Evidence
Health issue
Level of Concern
Source
Siloxanes
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
Per- and polyfluorinated chemicals (PFAS) are highly persistent in the environment, and humans are widely exposed to PFAS through the environment.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to immunotoxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to reproductive and developmental toxicity in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cancer in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to cardiovascular effects in humans and animals
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
Per- and polyfluorinated chemicals (PFAS) have been linked to thyroid disruption in humans and animals.
high
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
The European Union Ecolabel program reports this substance is persistent in the environment.
The European Union Ecolabel program reports this substance is persistent in the environment.
moderate
EU Ecolabel: Detergents Ingredients Database
Siloxanes
This substance is a PFAS, which is a chemical class of concern.
This substance is a PFAS, which is a chemical class of concern.
moderate
Carol F. Kwiatkowski, David Q. Andrews, Linda S. Birnbaum, Thomas A. Bruton, Jamie C. DeWitt, Detlef R. U. Knappe, Maricel V Maffini, Mark F. Miller, Katherine E. Pelch, Anna Reade, Anna Soehl, Xenia Trier, Marta Venier, Charlotte C. Wagner, Zhanyun Wang & Arlene Blum. 2020. Scientific Basis for Managing PFAS as a Chemical Class. Environmental science & technology letters 7(8), 532-543.
Siloxanes
The European Union Ecolabel program reports this substance is not anaerobically degradable.
The European Union Ecolabel program reports this substance is not anaerobically degradable.
some
EU Ecolabel: Detergents Ingredients Database
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
some
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
Per- and polyfluorinated chemicals (PFAS) have been linked to liver effects in humans and animals
some
Agency for Toxic Substances and Disease Registry (ATSDR). 2018. Toxicological Profile for Perfluoroalkyls.
Siloxanes
Organohalogen compounds are often found to be persistent in the environment, bioaccumulative, and associated with chronic health concerns
Organohalogen compounds are often found to be persistent in the environment, bioaccumulative, and associated with chronic health concerns
some
Prasada Rao S. Kodavanti & Bommanna G. Loganathan. 2017. Organohalogen Pollutants and Human Health. International Encyclopedia of Public Health, 359-366.
Siloxanes
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
Only in: Household Cleaners
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
Only in: Household Cleaners
low
EU Ecolabel: Detergents Ingredients Database
Impurities
Health issue
Level of Concern
Source
Siloxanes
Impurity: CYCLOTETRASILOXANE
Suspected of damaging fertility.
Impurity: CYCLOTETRASILOXANE
Suspected of damaging fertility.
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Siloxanes
Impurity: CYCLOTETRASILOXANE
Clear evidence of endocrine disruption in at least one animal study
Impurity: CYCLOTETRASILOXANE
Clear evidence of endocrine disruption in at least one animal study
some
EU Endocrine: EU Endocrine Disrupters
Siloxanes
Impurity: CYCLOTETRASILOXANE
May cause long lasting harmful effects to aquatic life
Impurity: CYCLOTETRASILOXANE
May cause long lasting harmful effects to aquatic life
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Siloxanes
Impurity: CYCLOPENTASILOXANE
NTP Toxcast scored 3.5-4.5
Impurity: CYCLOPENTASILOXANE
NTP Toxcast scored 3.5-4.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Siloxanes
Impurity: CYCLOTETRASILOXANE
NTP Toxcast scored 3.5-4.5
Impurity: CYCLOTETRASILOXANE
NTP Toxcast scored 3.5-4.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
