The Joint FAO/WHO Expert Committee on Food Additives reports that this substance causes blood effects in animals at high doses.
Joint FAO/WHO Expert Committee on Food Additives (JECFA). 1987. 30th Report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization Technical Report Series 751.
The Joint FAO/WHO Expert Committee on Food Additives reports that this substance causes blood effects in animals at high doses.
Joint FAO/WHO Expert Committee on Food Additives (JECFA). 1987. 30th Report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organization Technical Report Series 751.
A Cosmetic Ingredient Review panel reports this substance causes blood effects in animals at high doses.
Monice Zondlo Fiume. 2002. Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophe. International journal of toxicology 21 Suppl 3, 51-116.
A Cosmetic Ingredient Review panel reports this substance causes blood effects in animals at high doses.
Monice Zondlo Fiume. 2002. Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophe. International journal of toxicology 21 Suppl 3, 51-116.
The CIR panel reports equivocal evidence that tocopherol may act as a tumor promoter.
Cosmetic Ingredient Review (CIR): CIR Assessments
The CIR panel reports that tocopherol was a dermal sensitizer in an animal study and contact allergy has been reported in human tests and case studies, although occurrence is rare.
Cosmetic Ingredient Review (CIR): CIR Assessments
Concerns from impurities
Impurity: HYDROQUINONE
Suspected of causing genetic defects
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: HYDROQUINONE
Suspected of causing cancer
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: HYDROQUINONE
NTP Toxcast scored 1.5-2.5
National Toxicology Program (NTP): EWG Toxcast Analysis