The Power of Information

National Drinking Water Database


National Drinking Water Database - Chemical Contaminants

Mirex


Status: Unregulated - EPA has not established a maximum legal limit in tapwater for this contaminant.

Mirex is a banned insecticide that is bioaccumulative and resistant to degradation.

 
Detected
Found above
health guidelines
Found above
legal limit
States
1
1
-
Water utilities
2
1
-
People Served
1,150
350
-

Health Concerns for Mirex:


Mirex Exposure by State

Water utilities in 1 states have reported detecting Mirex in treated tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies.

StateWater Suppliers with Mirex contaminationWater suppliers reporting Mirex above health-based limits
SystemsPopulationSystemsPopulation
New York21,1501350
Total21,1501350

The Most Polluted Communities

2 water utilities reported detecting Mirex in tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies

Ranked by highest average Mirex level

RankSystem Population Served Positive test results of total reported tests Average Level
(Range)
1English Village Townhouses
Gansevoort, NY
3501 of 30.4 ppb
(0 to 1.2 ppb)
2Mcwa, Genesee West
Rochester, NY
8001 of 1< 0.01 ppb
(0.01 ppb)

Health Based Limits for Mirex

StandardDescriptionLevel
Health-Based Screening LevelA benchmark concentration of contaminants in water that may be of potential concern for human health, if exceeded. For noncarcinogens, the HBSL represents the contaminant concentration in drinking water that is not expected to cause any adverse effects over a lifetime of exposure. For carcinogens, the HBSL range represents the contaminant concentration in drinking water that corresponds to an excess estimated lifetime cancer risk of 1 chance in 1 million to 1 chance in 10 thousand. Source: U.S. Geological Survey.1 ppb

Testing Summary for Mirex

Are tests routinely required for Mirex by federal law?No
Water suppliers reporting tests for Mirex (2004-2008):105 of 47,576
Average testing rate for water supplier reporting tests (2004-2008):0.2 per year

Cancer

Type of concern: Reference:
Possible human carcinogen NTP Report on Carcinogens, 11th Edition
Possible human carcinogen California EPA Proposition 65
Cancer - strong evidence Proposition 65 List of Carcinogens
Limited evidence of carcinogenicity European Union - Classification & Labelling
Limited evidence of carcinogenicity Int'l Agency for Research on Cancer (IARC) - Carcinogens
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Toxicology Letters 1984
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Mutation Research 1995

Endocrine disruption

Type of concern: Reference:
Human disruptor - strong evidence European Commission on Endocrine Disruption
Limited evidence of wildlife and the environment disruption European Commission on Endocrine Disruption
Limited evidence of endocrine disruption BKH/European Commission, 2000
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study Illinois EPA Chemicals Associated with Endocrine System
endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study Our Stolen Future Endocrine Disruptors

Persistence and bioaccumulation

Type of concern: Reference:
Persistent, bioaccumulative in wildlife and humans National Library of Medicine HazMap
Persistent, bioaccumulative in wildlife and humans United Nations Environment Programme/POPs Treaty
Persistent, bioaccumulative in wildlife National Library of Medicine HazMap
Persistent, bioaccumulative in wildlife Great Lakes BTS (Binational Toxics Strategy) PBTs
Persistent, bioaccumulative in wildlife OSPAR PBTs - Substances of Possible Concern

Developmental/reproductive toxicity

Type of concern: Reference:
Limited evidence of developmental toxicity European Union - Classification & Labelling

Occupational hazards

Type of concern: Reference:
Allowed workplace exposures restricted to low doses European Union - Classification & Labelling

Organ system toxicity (non-reproductive)

Type of concern: Reference:
Classified as toxic or harmful European Union - Classification & Labelling
Limited evidence of gastrointestinal or liver toxicity National Library of Medicine HazMap
Limited evidence of gastrointestinal or liver toxicity Agency for Toxic Substances and Disease Registry, 2004
Limited evidence of kidney toxicity Merck & Co
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) National Library of Medicine HazMap

Ecotoxicology

Type of concern: Reference:
Wildlife and environmental toxicity European Union - Classification & Labelling
Wildlife and environmental toxicity Illinois EPA Chemicals Associated with Endocrine System



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
European Union - Classification & LabellingDODECACHLOROPENTACYCLO[5.2.1.02,6.03,9.05,8]DECANE•Limited evidence of a carcinogenic effect
•Limited evidence of a carcinogenic effect
•Limited evidence of reproductive toxicity
•Possible risk of impaired fertility
•May cause harm to breastfed babies
•Harmful
•Harmful in contact with skin and if swallowed
•Dangerous for the environment
•Very toxic to aquatic organisms, may cause long-term adverse effects in aquatic environments
Illinois EPA Chemicals Associated with Endocrine SystemMIREX•EPA: probable endocrine disruptor
European Union - Banned or Restricted in CosmeticsDODECACHLOROPENTACYCLO[5.2.1.02,6.03,9.05,8]DECANE•Prohibited in EU cosmetics: must not form part of the composition of cosmetic products
Int'l Agency for Research on Cancer (IARC) - CarcinogensMIREX•IARC Group 2B: possible human carcinogen (International Agency for Research on Carcinogens)
National Library of Medicine HazMapMIREX•Restricted - Regulations that have banned or restricted the use of the agent: All U.S. registrations cancelled; [EPA Pesticides, p. 56];
•Hepatotoxin: Hepatotoxin, Secondary;
•Bioaccumulates: Yes;
•Other Poison: Organochlorine Pesticide;
Aarhus Protocol on Persistent Organic Pollutants1,1A,2,2,3,3A,4,5,5,5A,5B,6-DODECACHLOROACTAHYDRO-1,3,4-METHENO-1H-CYCLOBUTA[CD]PENTALENEBanned under the Aahrus Protocol for Persistent Organic Pollutants
Great Lakes BTS (Binational Toxics Strategy) PBTs1,1A,2,2,3,3A,4,5,5,5A,5B,6-DODECACHLOROACTAHYDRO-1,3,4-METHENO-1H-CYCLOBUTA[CD]PENTALENE•Persistent, bioaccumulative toxicant - Great Lakes Binational Strategy, Tier 1 concern (highest), targeted for phase-out
OSPAR PBTs - Substances of Possible Concern1,1A,2,2,3,3A,4,5,5,5A,5B,6-DODECACHLOROACTAHYDRO-1,3,4-METHENO-1H-CYCLOBUTA[CD]PENTALENE•Persistent, bioaccumulative toxicant - Oslo-Paris (OSPAR) Convention for the Protection of the Marine Environment of the North-East Atlantic, chemical of concern
United Nations Environment Programme/POPs Treaty1,1A,2,2,3,3A,4,5,5,5A,5B,6-DODECACHLOROACTAHYDRO-1,3,4-METHENO-1H-CYCLOBUTA[CD]PENTALENE•Persistent, bioaccumulative toxicant - targeted for restrictions under international treaty (Stockholm Convention on Persistent Organic Pollutants, or POPs Convention)
NTP Report on Carcinogens, 11th EditionMIREX•Reasonably anticipated to be a human carcinogen (National Toxicology Program classification)
Our Stolen Future Endocrine DisruptorsMIREX
California EPA Proposition 65MIREX•Carcinogen: California Proposition 65
Agency for Toxic Substances and Disease Registry, 2004MIREX•Gastrointestinal or liver toxicity hazards: suspected
BKH/European Commission, 2000MIREX•Endocrine toxicity hazards: suspected
Merck & CoMIREX•Kidney toxicity hazards: suspected
Proposition 65 List of CarcinogensMIREX•Cancer hazards: recognized
European Commission on Endocrine DisruptionMIREXHH-CAT1;WF-CAT2
RTECS®- Mutation Research 1995DODECACHLOROPENTACYCLO[5.2.1.02,6.03,9.05,8]DECANE• mutagenic - Positive mutation assay: other mutation test systems (mouse orl)
RTECS®- Toxicology Letters 1984DODECACHLOROPENTACYCLO[5.2.1.02,6.03,9.05,8]DECANE• mutagenic - Positive mutation assay: other mutation test systems (rat orl)



references

government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Illinois EPA Chemicals Associated with Endocrine SystemIllinois EPA (Illinois Environmental Protection Agency). 2000. Preliminary list of chemicals associated with endocrine system effects in animals and humans (*) or in vitro (+). In EPA (U.S. Environmental Protection Agency) 2000. Handbook for Non-Cancer Health Effects Valuation, Appendix C.
European Union - Banned or Restricted in CosmeticsEC (European Commission of the European Union). 1999-2006. Enterprise Directorate-General Pharmaceuticals and Cosmetics. The rules governing cosmetic products in the European Union, Volume 1, "Cosmetics legislation."
Int'l Agency for Research on Cancer (IARC) - CarcinogensIARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Aarhus Protocol on Persistent Organic PollutantsAarhus LRTAP. 1998. Aarhus Protocol on Persistent Organic Pollutants (POPs). Geneva Convention on Long-range Transboundary Air Pollution, United Nations Environment Program.
Great Lakes BTS (Binational Toxics Strategy) PBTsGreat Lakes BTS (Binational Toxics Strategy). 1997. Canada-United States Strategy for the Virtual Elimination of Persistent Toxic Substances in the Great Lakes. Appendix I - Level 1 and Level 2 substances.
OSPAR PBTs - Substances of Possible ConcernOSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
United Nations Environment Programme/POPs TreatyUNEP (United Nations Environment Programme). 2001. Stockholm Convention on Persistent Organic Pollutants (POPs) — POPs Treaty.
NTP Report on Carcinogens, 11th EditionNTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Our Stolen Future Endocrine DisruptorsColborn T, D Dumanoski, JP Myers. 2006. Widespread Pollutants with Endocrine-disrupting Effects. Updated from original listing in "Our Stolen Future" (1996).
California EPA Proposition 65California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
Scorecard.org Toxicity InformationAgency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
Scorecard.org Toxicity InformationBKH/European Commission. Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption: - preparation of a candidate list of substances as a basis for priority setting. Final report-November 2000. http://europa.eu.int/comm/environment/docum/01262_en.htm#bkh. Category 1 chemicals from Annex 1: Candidate list of 553 substances. http://europa.eu.int/comm/environment/docum/bkh_annex_01.pdf, UUS EPA. Announcement of the Draft Drinking Water Contaminant Candidate List; Notice. 62 Federal Register 52193-52219 (October 6, 1997). (Table 6). http://www.epa.gov/safewater/ccl/dwccl.pdf, Illinois EPA. Endocrine Disruptors Strategy. 1997. (Table 1: Preliminary List of Chemicals Associated with Endocrine System Effects in Animals and Humans or In Vitro). http://www.nihs.go.jp/hse/environ/illiepatable.htm, Japanese National Institute of Health Sciences. Lists of Paradigmatic Chemicals. http://www.nihs.go.jp/hse/endocrine-e/paradigm/paradigm.html, Keith, L.H. (ed.). Environmental Endocrine Disruptors. John Wiley & Sons, NY. 1997. http://www.wileyeurope.com/cda/product/0,,0471191450%7Cdesc%7C3037,00.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation., World Wildlife Fund. Our Stolen Future. Widespread Pollutants with Endocrine-disrupting Effects. http://www.ourstolenfuture.org/Basics/chemlist.htm. The WWF list is derived from references detailed at http://www.ourstolenfuture.org/Sources/chemsources.htm and was originally published in: Colborn, T., F.S. vom Saal, and A.M. Soto. Developmental Effects of Endocrine-Disrupting Chemicals In Wildlife and Humans. Environmental Health Perspectives 101(5): 378-384. 1993.
Scorecard.org Toxicity InformationMerck & Co. The Merck Manual of Diagnosis and Therapy. TABLE 226-1. Common Nephrotoxic Agents http://www.merck.com/pubs/mmanual/tables/226tb1.htm
Scorecard.org Toxicity InformationProposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.
European Commission on Endocrine DisruptionEU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
RTECS®- Mutation Research 1995RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 343,157,1995
RTECS®- Toxicology Letters 1984RTECS®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 23,127,1984

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.