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National Drinking Water Database


National Drinking Water Database - Chemical Contaminants

Methyl isobutyl ketone


Status: Unregulated - EPA has not established a maximum legal limit in tapwater for this contaminant.

Methyl isobutyl ketone (4-Methyl-2-pentanone) is an industrial chemical used in the production of paints, pesticides, textiles, inks and rubber.

 
Detected
Found above
health guidelines
Found above
legal limit
States
5
-
-
Water utilities
141
-
-
People Served
3,577,609
-
-

Health Concerns for Methyl isobutyl ketone:


Methyl isobutyl ketone Exposure by State

Water utilities in 5 states have reported detecting Methyl isobutyl ketone in treated tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies.

StateWater Suppliers with Methyl isobutyl ketone contamination
SystemsPopulation
Texas1093,130,026
Delaware6206,713
Minnesota22171,863
California256,982
Michigan212,025
Total1413,577,609

The Most Polluted Communities

141 water utilities reported detecting Methyl isobutyl ketone in tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies

Ranked by highest average Methyl isobutyl ketone level

RankSystem Population Served Positive test results of total reported tests Average Level
(Range)
1Marietta
Marietta, MN
1741 of 193 ppb
(93 ppb)
2City of Rio Vista
Rio Vista, TX
6501 of 150 ppb
(50 ppb)
3Brazoria County Mud 6
Sugar Land, TX
1,6921 of 120.5 ppb
(20.5 ppb)
4Iona
Iona, MN
1611 of 120 ppb
(20 ppb)
5Grand Meadow
Grand Meadow, MN
9452 of 318.33 ppb
(0 to 33 ppb)
6Country Meadows
Glen Rose, TX
1201 of 117.79 ppb
(17.79 ppb)
7Durham Park Wsc
Liberty Hill, TX
5581 of 616.67 ppb
(0 to 100 ppb)
8Selbyville Water Department
Selbyville, DE
1,6451 of 315.43 ppb
(0 to 46.3 ppb)
9Voshells Cove
Dover, DE
2521 of 114 ppb
(14 ppb)
10Yancey Wsc
Yancey, TX
4,7311 of 112.77 ppb
(12.77 ppb)

Testing Summary for Methyl isobutyl ketone

Are tests routinely required for Methyl isobutyl ketone by federal law?No
Water suppliers reporting tests for Methyl isobutyl ketone (2004-2009):5,691 of 47,576
Average testing rate for water supplier reporting tests (2004-2009):0.6 per year

Allergies/immunotoxicity

Type of concern: Reference:
Human toxicant or allergen - strong evidence Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

Type of concern: Reference:
Known human respiratory toxicant EPA Hazardous Air Pollutants
One or more animal studies show sense organ effects at very low doses RTECS®- Union Carbide Data Sheet 1958
Classified as expected to be toxic or harmful Environment Canada Domestic Substance List
One or more animal studies show sense organ effects at low doses RTECS®- National Technical Information Service 5383
Limited evidence of respiratory toxicity US EPA, Air Risk Information Support Center
Limited evidence of sense organ toxicity US EPA, Air Risk Information Support Center
Limited evidence of gastrointestinal or liver toxicity US EPA, Air Risk Information Support Center
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient) EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) EPA Toxic Release Inventory PBTs
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Union Carbide Data Sheet 1958
One or more animal studies show sense organ effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Journal of Industrial Hygiene and Toxicology 1946

Occupational hazards

Type of concern: Reference:
Allowed workplace exposures restricted to low doses European Union - Classification & Labelling
Allowed workplace exposures restricted to high doses RTECS®- TLV/BEI,2006
Allowed workplace exposures restricted to high doses RTECS®- MSHA STANDARD-air: 3,126,1971
Allowed workplace exposures restricted to high doses RTECS®- OSHA PEL (Gen Indu): 29,1910 1994
Allowed workplace exposures restricted to high doses RTECS®- OSHA PEL (Construc): 29,1926 1994
Allowed workplace exposures restricted to high doses RTECS®- OSHA PEL (Shipyard): 29,1915 1993
Allowed workplace exposures restricted to high doses RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994
Allowed workplace exposures restricted to high doses RTECS®- TLV/BEI,2007

Irritation (skin, eyes, or lungs)

Type of concern: Reference:
Classified as irritant European Union - Classification & Labelling
Human irritant - strong evidence Cosmetic Ingredient Review Assessments
One or more animal studies show skin irritation at moderate doses RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986

Neurotoxicity

Type of concern: Reference:
One or more animal studies show brain, nervous system, or behavioral effect effects at high doses RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1973
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study National Library of Medicine HazMap

Miscellaneous

Type of concern: Reference:
Occupational hazards related to handling European Union - Classification & Labelling

Multiple, additive exposure sources

Type of concern: Reference:
Designated as safe for general or specific, limited use in food FDA Everything Added to Food



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
European Union - Classification & Labelling4-METHYLPENTAN-2-ONE•Highly flammable
•Highly flammable
•Harmful
•Harmful by inhalation
•Irritant (eyes, skin, or lungs)
•Irritating to eyes and respiratory system
•Repeated exposure may cause skin dryness or cracking
Association of Occupational and Environmental ClinicsMETHYL ISOBUTYL KETONE• S
Association of Occupational and Environmental ClinicsMETHYL ISOBUTYL KETONE• S
Association of Occupational and Environmental ClinicsMETHYL ISOBUTYL KETONE• S
Association of Occupational and Environmental ClinicsMETHYL ISOBUTYL KETONE• S
Cosmetic Ingredient Review AssessmentsMETHYL ISOBUTYL KETONE•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR)
•Product type restrictions or differences noted in safety assessment by industry panel
Cosmetic Ingredient Review AssessmentsMIBK•Safe for use in cosmetics with some qualifications
•Industry safety panel (Cosmetic Ingredient Review, CIR) notes missing safety data in its review of this ingredient
•Avoid skin contact
•Product type restrictions or differences noted in safety assessment by industry panel
•May contain harmful impurities

•Lung sensitizer
•Irritation (eyes, skin, or lungs)
FDA Everything Added to FoodMETHYL ISOBUTYL KETONE• Fully up-to-date toxicology information has been sought.
Environment Canada Domestic Substance List2-PENTANONE, 4-METHYL-•This chemical was deemed a moderate human health priority and was flagged by CEPA for further attention.
EPA Integrated Risk Information System (IRIS)METHYL ISOBUTYL KETONE (MIBK)Data are inadequate for an assessment of human carcinogenic potential
IFRA Fragrance Ingredient List4-METHYL-2-PENTANONE•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
EPA Hazardous Air PollutantsMETHYL ISOBUTYL KETONE (HEXONE)•Hazardous air pollutant under Clean Air Act
National Library of Medicine HazMapMETHYL ISOBUTYL KETONE•Neurotoxin: CNS Solvent Syndrome;
•PEL (OSHA) - Permissible exposure limit (OSHA): 100 ppm;
•STEL (ACGIH) - Short-term exposure limits (ACGIH): 75 ppm;
•LC50 - Lethal concentration in 50% of animals tested: 8000 ppm;
•TLV (ACGIH) - Threshold limit value (ACGIH): 50 ppm;
•BEI - Biological Exposure Indices (American Conference of Governmental Industrial Hygiene, ACGIH): MIBK in urine = 2 mg/L; sample at end of shift;;
•Flammability (NFPA) - NFPA flammability code: 0 = will not burn; 1 = must be preheated; 2 = high ambient temp required; 3 = may ignite at ambient temp; 4 = burn readily: 3: may ignite at ambient temperature;
•IDLH (NIOSH) - Immediately Dangerous to Life or Health: 500 ppm;
•Odor Threshold High - The lowest concentration at which a substance can be detected or recognized using the sense of smell: 7.8 ppm;
•Odor Threshold Low - The lowest concentration at which a substance can be detected or recognized using the sense of smell: 0.1 ppm;
•MAK - Maximum Allowable Concentration (Federal Republic of Germany): 20 ppm;
EPA Categorized List of Inert Pesticide IngredientsMETHYL ISOBUTYL KETONE•Pesticide inerts: potentially toxic, testing priority, according to EPA (Environmental Protection Agency)
EPA Categorized List of Inert Pesticide IngredientsMETHYL ISOBUTYL KETONE•Pesticide inerts: potentially toxic, testing priority, according to EPA (Environmental Protection Agency)
EPA Toxic Release Inventory PBTs4METHYL2PENTANONE•Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs
US EPA, Air Risk Information Support CenterMETHYL ISOBUTYL KETONE•Respiratory toxicity hazards: suspected
US EPA, Air Risk Information Support CenterMETHYL ISOBUTYL KETONE•Skin or sense organ toxicity hazards: suspected
US EPA, Air Risk Information Support CenterMETHYL ISOBUTYL KETONE•Gastrointestinal or liver toxicity hazards: suspected
RTECS®- TLV/BEI,2006MIBK• occupationally related - ACGIH TLV (human TWA)
RTECS®- TLV/BEI,2007MIBK• occupationally related - ACGIH TLV (human TWA)
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986MIBK• skin - Primary skin irritant (rabbit )
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1973MIBK• brain, nervous system, or behavioral effect - Convulsions or effect on seizure threshold (rat TDLo)
RTECS®- Journal of Industrial Hygiene and Toxicology 1946MIBK• sense organ - Primary eye irritant ( human )
RTECS®- MSHA STANDARD-air: 3,126,1971MIBK• occupationally related - MSHA STANDARD-air (human TWA)
RTECS®- National Technical Information Service 5383MIBK• sense organ - Primary eye irritant (rabbit )
RTECS®- National Technical Information Service 5383MIBK• sense organ - Primary eye irritant (rabbit )
RTECS®- OSHA PEL (Construc): 29,1926 1994MIBK• occupationally related - OSHA PEL (Construc) (human TWA)
RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994MIBK• occupationally related - OSHA PEL (Fed Cont) (human TWA)
RTECS®- OSHA PEL (Gen Indu): 29,1910 1994MIBK• occupationally related - OSHA PEL (Gen Indu) (human TWA)
RTECS®- OSHA PEL (Shipyard): 29,1915 1993MIBK• occupationally related - OSHA PEL (Shipyard) (human TWA)
RTECS®- Union Carbide Data Sheet 1958MIBK• broad systemic - Broad systemic toxicity (rat LD50)
• sense organ - Primary eye irritant (rabbit )



references

government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA Integrated Risk Information System (IRIS)EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
EPA Hazardous Air PollutantsEPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
EPA Categorized List of Inert Pesticide IngredientsEPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
EPA Toxic Release Inventory PBTsEPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
Scorecard.org Toxicity InformationUS EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html
Scorecard.org Toxicity InformationUS EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html
Scorecard.org Toxicity InformationUS EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
RTECS®- TLV/BEI,2006RTECS®- TLV/BEI,2006
RTECS®- TLV/BEI,2007RTECS®- TLV/BEI,2007
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,284,1986
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1973RTECS®- Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI 17(11),52,1973
RTECS®- Journal of Industrial Hygiene and Toxicology 1946RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 28,262,1946
RTECS®- MSHA STANDARD-air: 3,126,1971RTECS®- MSHA STANDARD-air: 3,126,1971
RTECS®- National Technical Information Service 5383RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0535383
RTECS®- National Technical Information Service 5383RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0535383
RTECS®- OSHA PEL (Construc): 29,1926 1994RTECS®- OSHA PEL (Construc): 29,1926.55,1994
RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994RTECS®- OSHA PEL (Fed Cont): 41,50-204.50,1994
RTECS®- OSHA PEL (Gen Indu): 29,1910 1994RTECS®- OSHA PEL (Gen Indu): 29,1910.1000,1994
RTECS®- OSHA PEL (Shipyard): 29,1915 1993RTECS®- OSHA PEL (Shipyard): 29,1915.1000,1993
RTECS®- Union Carbide Data Sheet 1958RTECS®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 4/25/1958

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