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National Drinking Water Database


National Drinking Water Database - Chemical Contaminants

Di-n-octylphthalate


Status: Unregulated - EPA has not established a maximum legal limit in tapwater for this contaminant.

Di-n-octylphthalate is a synthetic chemical used to keep plastics soft or more flexible; it is found in diverse industrial and consumer products that range from cosmetics to pesticides.

 
Detected
Found above
health guidelines
Found above
legal limit
States
2
-
-
Water utilities
4
-
-
People Served
201,332
-
-

Health Concerns for Di-n-octylphthalate:


Di-n-octylphthalate Exposure by State

Water utilities in 2 states have reported detecting Di-n-octylphthalate in treated tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies.

StateWater Suppliers with Di-n-octylphthalate contamination
SystemsPopulation
Delaware1201,000
California3332
Total4201,332

The Most Polluted Communities

4 water utilities reported detecting Di-n-octylphthalate in tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies

Ranked by highest average Di-n-octylphthalate level

RankSystem Population Served Positive test results of total reported tests Average Level
(Range)
1South Kern Mutual Water Company
Old River, CA
391 of 10.11 ppb
(0.11 ppb)
2Allen Road Mutual Water System
Bakersfield, CA
2251 of 10.11 ppb
(0.11 ppb)
3St. Clair Ranchos Mutual Water Co.
Bakersfield, CA
681 of 10.11 ppb
(0.11 ppb)
4Artesian Water Company
Newark, DE
201,0002 of 730.01 ppb
(0 to 0.63 ppb)

Testing Summary for Di-n-octylphthalate

Are tests routinely required for Di-n-octylphthalate by federal law?No
Water suppliers reporting tests for Di-n-octylphthalate (2004-2009):214 of 47,576
Average testing rate for water supplier reporting tests (2004-2009):0.6 per year

Organ system toxicity (non-reproductive)

Type of concern: Reference:
One or more animal studies show sense organ effects at very low doses RTECS®- American Journal of Ophthalmology 1946
Limited evidence of gastrointestinal or liver toxicity Agency for Toxic Substances and Disease Registry, 2004
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient) EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) EPA Toxic Release Inventory PBTs
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient) RTECS®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1979
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- EHP, Environmental Health Perspectives 1986
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 2000
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Toxicologist 1988
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Toxicology and Applied Pharmacology 1985
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Journal of the Society of Cosmetic Chemists 1977
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1973
One or more animal studies show blood effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- EHP, Environmental Health Perspectives 1986
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Farmakologiya i Toksikologiya (Moscow) 1976
One or more animal studies show blood effects at high doses (low dose studies may be unavailable for this ingredient) RTECS®- Indian Journal of Experimental Biology 1985
Classified as not expected to be potentially toxic or harmful Environment Canada Domestic Substance List

Endocrine disruption

Type of concern: Reference:
Limited evidence of endocrine disruption Brucker-Davis, F, 1998
One or more animal studies show endocrine system disruption at high doses RTECS®- EHP, Environmental Health Perspectives 1986
One or more animal studies show endocrine system disruption at high doses RTECS®- Indian Journal of Experimental Biology 1985
One or more animal studies show endocrine system disruption at high doses RTECS®- Industrial Health 1987

Persistence and bioaccumulation

Type of concern: Reference:
Persistent, bioaccumulative in wildlife OSPAR PBTs - Substances of Possible Concern
Not suspected to be bioaccumulative Environment Canada Domestic Substance List
Not suspected to be persistent Environment Canada Domestic Substance List

Neurotoxicity

Type of concern: Reference:
One or more animal studies show brain, nervous system, or behavioral effects at moderate doses RTECS®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1979

Developmental/reproductive toxicity

Type of concern: Reference:
One or more animal studies show developmental effects at high doses RTECS®- Journal of Pharmaceutical Sciences 1972
One or more animal studies show reproductive effects at high doses RTECS®- Weisheng Dulixue Zazhi 1993
One or more animal studies show reproductive effects at high doses RTECS®- Journal of Pharmaceutical Sciences 1972
One or more animal studies show reproductive effects at high doses RTECS®- National Technical Information Service 0143
One or more animal studies show reproductive effects at high doses RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis 1987
One or more animal studies show reproductive effects at high doses RTECS®- National Technical Information Service 8147

Biochemical or cellular level changes

Type of concern: Reference:
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood RTECS®- Toxicology and Applied Pharmacology 1985

Ecotoxicology

Type of concern: Reference:
Wildlife and environmental toxicity EPA Clean Water Act - Priority Pollutants
Suspected to be an environmental toxin Environment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

Type of concern: Reference:
One or more animal studies show skin irritation at moderate doses RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
EPA Clean Water Act - Priority PollutantsDI-N-OCTYL PHTHALATE•Priority water pollutant under the Clean Water Act
Environment Canada Domestic Substance List1,2-BENZENEDICARBOXYLIC ACID, DIOCTYL ESTER•This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected aquatic toxicity.
European Commission on Endocrine DisruptionDI-N-OCTYLPHTHALATE (DNOP)HH-CAT3b;WF-CAT3b
European Commission on Endocrine Disruption1,2-BENZENEDICARBOXYLIC ACID, DIOCTYL ESTERHH-CAT3b;WF-CAT3b
IFRA Fragrance Ingredient ListDIOCTYL PHTHALATE•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
EPA Categorized List of Inert Pesticide IngredientsDIOCTYL PHTHALATE•Pesticide inerts: potentially toxic, testing priority, according to EPA (Environmental Protection Agency)
NTP - Risks to Human ReproductionDI-N-OCTYL PHTHALATEREPRO: Men: negligible concern. Women: negligible concern. || DEVELOPMENT: Data are insufficient to reach conclusions.
OSPAR PBTs - Substances of Possible ConcernDIOCTYL ESTER1,2-BENZENEDICARBOXYLIC ACID•Persistent, bioaccumulative toxicant - Oslo-Paris (OSPAR) Convention for the Protection of the Marine Environment of the North-East Atlantic, chemical of concern
EPA Toxic Release Inventory PBTsDIOCTYL ESTER1,2-BENZENEDICARBOXYLIC ACID•Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs
Agency for Toxic Substances and Disease Registry, 2004DI-N-OCTYL PHTHALATE•Gastrointestinal or liver toxicity hazards: suspected
Brucker-Davis, F, 1998DI-N-OCTYL PHTHALATE•Endocrine toxicity hazards: suspected
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986DIOCTYL PHTHALATE, ISO• sense organ - Primary eye irritant (rabbit )
• skin - Primary skin irritant (rabbit )
RTECS®- American Journal of Ophthalmology 1946DIOCTYL PHTHALATE, ISO• sense organ - Primary eye irritant (rabbit )
RTECS®- American Journal of Ophthalmology 1946DIOCTYL PHTHALATE, ISO• sense organ - Primary eye irritant (rabbit )
RTECS®- EHP, Environmental Health Perspectives 1986DIOCTYL PHTHALATE, ISO• liver - Changes in liver weight (rat TDLo)
• endocrine system - Evidence of thyroid hypofunction (rat TDLo)
• liver - Fatty liver degeneration (rat TDLo)
• liver - Hepatitis (hepatocellular necrosis), zonal (rat TDLo)
• blood - Other changes (rat TDLo)
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1976DIOCTYL PHTHALATE, ISO• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1973DIOCTYL PHTHALATE, ISO• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Indian Journal of Experimental Biology 1985DIOCTYL PHTHALATE, ISO• blood - Changes in spleen (rat TDLo)
• endocrine system - Other changes (rat TDLo)
RTECS®- Industrial Health 1987DIOCTYL PHTHALATE, ISO• immune system - Decrease in humoral immune response (rat TDLo)
• immune system - Decreased immune response (rat TDLo)
• endocrine system - Other changes (rat TDLo)
RTECS®- Journal of Pharmaceutical Sciences 1972DIOCTYL PHTHALATE, ISO• reproductive - Fetotoxicity (rat TDLo)
• developmental - Other developmental abnormalities (rat TDLo)
RTECS®- Journal of the Society of Cosmetic Chemists 1977DIOCTYL PHTHALATE, ISO• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- National Technical Information Service 8147DIOCTYL PHTHALATE, ISO• reproductive - Hepatobiliary system (mouse TDLo)
RTECS®- National Technical Information Service 0143DIOCTYL PHTHALATE, ISO• reproductive - Live birth index (mouse TDLo)
RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis 1987DIOCTYL PHTHALATE, ISO• reproductive - Live birth index (mouse TDLo)
RTECS®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1979DIOCTYL PHTHALATE, ISO• respiratory - Dyspnea (rat TDLo)
• respiratory - Respiratory depression (rat TDLo)
• brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (rat TDLo)
RTECS®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 2000DIOCTYL PHTHALATE, ISO• liver - Other changes (mouse TDLo)
RTECS®- Toxicologist 1988DIOCTYL PHTHALATE, ISO• liver - Fatty liver degeneration (rat TDLo)
• liver - Other changes (rat TDLo)
RTECS®- Toxicology and Applied Pharmacology 1985DIOCTYL PHTHALATE, ISO• liver - Changes in liver weight (rat TDLo)
• liver - Fatty liver degeneration (rat TDLo)
• biochemical - Phosphatases (rat TDLo)
RTECS®- Weisheng Dulixue Zazhi 1993DIOCTYL PHTHALATE, ISO• reproductive - Spermatogenesis (rat TDLo)
• reproductive - Testes, epididymis, sperm duct (rat TDLo)



references

government/industry list/academic study reference
EPA Clean Water Act - Priority Pollutants
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission on Endocrine DisruptionEU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
EPA Categorized List of Inert Pesticide IngredientsEPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
NTP - Risks to Human ReproductionNTP (National Toxicology Program). 2006. NTP Center for the Evaluation fo Risks to Human Reproduction (CERHR). NTP-CERHR Reports and Monographs.
OSPAR PBTs - Substances of Possible ConcernOSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
EPA Toxic Release Inventory PBTsEPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
Scorecard.org Toxicity InformationAgency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html
Scorecard.org Toxicity InformationBrucker-Davis, F. Effects of Environmental Synthetic Chemicals on Thyroid Function. Thyroid. 8(9): 827-856. 1998., Japanese National Institute of Health Sciences. Lists of Paradigmatic Chemicals. http://www.nihs.go.jp/hse/endocrine-e/paradigm/paradigm.html
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,390,1986
RTECS®- American Journal of Ophthalmology 1946RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- 29,1363,1946
RTECS®- American Journal of Ophthalmology 1946RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 29,1363,1946
RTECS®- EHP, Environmental Health Perspectives 1986RTECS®- EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- 70,195,1986
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1976RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 39,635,1976
RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1973RTECS®- Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI 17(11),51,1973
RTECS®- Indian Journal of Experimental Biology 1985RTECS®- Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 23,315,1985
RTECS®- Industrial Health 1987RTECS®- Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963- 25,97,1987
RTECS®- Journal of Pharmaceutical Sciences 1972RTECS®- Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- 61,51,1972
RTECS®- Journal of the Society of Cosmetic Chemists 1977RTECS®- Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- 28,667,1977
RTECS®- National Technical Information Service 8147RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. #PB85218147
RTECS®- National Technical Information Service 0143RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB85-220143
RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis 1987RTECS®- Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- 7,29,1987
RTECS®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv 1979RTECS®- Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- 15,123,1979
RTECS®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V 2000RTECS®- Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998- 54,312,2000
RTECS®- Toxicologist 1988RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 8,38,1988
RTECS®- Toxicology and Applied Pharmacology 1985RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 77,116,1985
RTECS®- Weisheng Dulixue Zazhi 1993RTECS®- Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987 7,83,1993

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