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National Drinking Water Database


National Drinking Water Database - Chemical Contaminants

2,6-Dinitrotoluene


Status: Unregulated - EPA has not established a maximum legal limit in tapwater for this contaminant.

2,6-Dinitrotoluene is a chemical intermediate in the production of other industrial chemicals, dyes, explosives and propellants.

 
Detected
Found above
health guidelines
Found above
legal limit
States
1
-
-
Water utilities
1
-
-
People Served
4,100
-
-

Health Concerns for 2,6-Dinitrotoluene:


2,6-Dinitrotoluene Exposure by State

Water utilities in 1 states have reported detecting 2,6-Dinitrotoluene in treated tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies.

StateWater Suppliers with 2,6-Dinitrotoluene contamination
SystemsPopulation
Missouri14,100
Total14,100

The Most Polluted Communities

1 water utilities reported detecting 2,6-Dinitrotoluene in tap water since 2004, according to EWG's analysis of water quality data supplied by state water agencies

Ranked by highest average 2,6-Dinitrotoluene level

RankSystem Population Served Positive test results of total reported tests Average Level
(Range)
1Butler
Butler, MO
4,1001 of 3< 0.01 ppb
(< .01 to 0.0045 ppb)

Health Based Limits for 2,6-Dinitrotoluene

StandardDescriptionLevel
One in one million (10-6) Cancer RiskThe concentration of a chemical in drinking water corresponding to an excess estimated lifetime cancer risk of 1 in 1,000,000. Source: U.S. Environmental Protection Agency.0.05 ppb
Health-Based Screening LevelA benchmark concentration of contaminants in water that may be of potential concern for human health, if exceeded. For noncarcinogens, the HBSL represents the contaminant concentration in drinking water that is not expected to cause any adverse effects over a lifetime of exposure. For carcinogens, the HBSL range represents the contaminant concentration in drinking water that corresponds to an excess estimated lifetime cancer risk of 1 chance in 1 million to 1 chance in 10 thousand. Source: U.S. Geological Survey.0.05 ppb-5 ppb
One in ten thousand (10-4) Cancer RiskThe concentration of a chemical in drinking water corresponding to an excess estimated lifetime cancer risk of 1 in 10,000. Source: U.S. Environmental Protection Agency.5 ppb
Drinking Water Equivalent LevelA lifetime exposure concentration protective of adverse, noncarcinogenic health effects, that assumes all of the exposure to a contaminant is from drinking water. Source: U.S. Environmental Protection Agency.40 ppb
Children's health-based limit for 1-day exposureConcentration of a chemical in drinking water that is not expected to cause any adverse, noncarcinogenic health effects for up to one day of exposure. The One-Day health-based limit (or Health Advisory, HA) is typically set to protect a 10-kg child consuming 1 liter of water per day. Source: U.S. Environmental Protection Agency.400 ppb
Children's health-based limit for 10-day exposureConcentration of a chemical in drinking water that is not expected to cause any adverse, noncarcinogenic effects for up to ten days of exposure. The Ten-Day health-based limit (or Health Advisory, HA) is typically set to protect a 10-kg child consuming 1 liter of water per day. Source: U.S. Environmental Protection Agency.400 ppb

Testing Summary for 2,6-Dinitrotoluene

Are tests routinely required for 2,6-Dinitrotoluene by federal law?No
Water suppliers reporting tests for 2,6-Dinitrotoluene (2004-2009):608 of 47,576
Average testing rate for water supplier reporting tests (2004-2009):0.4 per year

Developmental/reproductive toxicity

Type of concern: Reference:
Human reproductive toxicant - strong evidence Proposition 65 List of Carcinogens
Limited evidence of developmental toxicity European Union - Classification & Labelling
Possible human reproductive or developmental toxin Environment Canada Domestic Substance List

Cancer

Type of concern: Reference:
Possible human carcinogen European Union - Classification & Labelling
Possible human carcinogen California EPA Proposition 65
Cancer - strong evidence Proposition 65 List of Carcinogens
Limited evidence of carcinogenicity Amer Conf of Gov't Industrial Hygienists - Carcinogens
Limited evidence of carcinogenicity Int'l Agency for Research on Cancer (IARC) - Carcinogens
Possible carcinogen Environment Canada Domestic Substance List
Possible mutagen Environment Canada Domestic Substance List
Mutagen - limited evidence European Union - Classification & Labelling
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Carcinogenesis (London) 1986
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Mutation Research 1993
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Journal of Toxicology and Environmental Health 1983
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Personal Communication from J 1982
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Cell Biology and Toxicology 1991
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Carcinogenesis (London) 1982
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Cancer Letters (Shannon, Ireland) 1990
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- National Technical Information Service
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Carcinogenesis (London) 1984
One or more in vitro tests on mammalian cells show positive mutation results RTECS®- Environmental and Molecular Mutagenesis 2004
One or more in vitro tests non-mammalian cells show positive mutation results RTECS®- Developments in Toxicology and Environtal Science 1977
One or more in vitro tests non-mammalian cells show positive mutation results RTECS®- Sangyo Igaku 1987

Organ system toxicity (non-reproductive)

Type of concern: Reference:
Classified as a high human health priority Environment Canada Domestic Substance List
Classified as expected to be toxic or harmful Environment Canada Domestic Substance List
Classified as toxic or harmful European Union - Classification & Labelling
Limited evidence of cardiovascular or blood toxicity Agency for Toxic Substances and Disease Registry, 2004
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) EPA Toxic Release Inventory PBTs

Persistence and bioaccumulation

Type of concern: Reference:
Persistent, bioaccumulative in wildlife Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)
Not suspected to be bioaccumulative Environment Canada Domestic Substance List

Occupational hazards

Type of concern: Reference:
Allowed workplace exposures restricted to low doses European Union - Classification & Labelling
Limited evidence of occupational hazards European Union - Classification & Labelling

Ecotoxicology

Type of concern: Reference:
Wildlife and environmental toxicity European Union - Classification & Labelling
Wildlife and environmental toxicity EPA Clean Water Act - Priority Pollutants
Not suspected to be an environmental toxin Environment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

Type of concern: Reference:
One or more animal studies show skin irritation at moderate doses RTECS®- National Technical Information Service



Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
European Union - Classification & Labelling2,6-DINITROTOLUENE•May cause cancer
•May cause cancer
•Limited evidence of mutagenic effect
•Possible risk of irreversible effects
•Limited evidence of reproductive toxicity
•Possible risk of impaired fertility
•Toxic
•Toxic by inhalation, skin contact, and ingestion
•Harmful
•Harmful: danger of serious damage to health by prolonged exposure if swallowed
•Harmful to aquatic organisms
Amer Conf of Gov't Industrial Hygienists - CarcinogensDINITROTOLUENE, 2,4 AND 2,6•Confirmed animal carcinogen with unknown relevance to humans (ACGIH classification A3)
EPA Clean Water Act - Priority Pollutants2,6-DINITROTOLUENE•Priority water pollutant under the Clean Water Act
European Union - Banned or Restricted in Cosmetics2,6-DINITROTOLUENE•Prohibited in EU cosmetics: must not form part of the composition of cosmetic products
Int'l Agency for Research on Cancer (IARC) - Carcinogens2,6-DINITROTOLUENE•IARC Group 2B: possible human carcinogen (International Agency for Research on Carcinogens)
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)2METHYL1,3DINITROBENZENE•Toxicant of concern under Canada's Accelerated Reduction/Elimination of Toxics program - targeted for elimination or reduction
EPA Toxic Release Inventory PBTs2METHYL1,3DINITROBENZENE•Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs
California EPA Proposition 652,6-DINITROTOLUENE•Carcinogen: California Proposition 65
Agency for Toxic Substances and Disease Registry, 20042,6-DINITROTOLUENE•Cardiovascular or blood toxicity hazards: suspected
Proposition 65 List of Carcinogens2,6-DINITROTOLUENE•Cancer hazards: recognized
Proposition 65 List of Carcinogens2,6-DINITROTOLUENE•Reproductive toxicity hazards: recognized
Environment Canada Domestic Substance ListBENZENE, 2-METHYL-1,3-DINITRO-•This chemical was deemed a high human health priority and was flagged by CEPA for further attention. The chemical is suspected to be carcinogenic, genotoxic, developmental and reproductive toxin, and persistent.
RTECS®- Cancer Letters (Shannon, Ireland) 19902,6-DINITROTOLUENE• mutagenic - Positive mutation assay: body fluid assay (rat )
RTECS®- Carcinogenesis (London) 19822,6-DINITROTOLUENE• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat orl)
RTECS®- Carcinogenesis (London) 19842,6-DINITROTOLUENE• mutagenic - Positive mutation assay: DNA Adduct (mouse skn)
RTECS®- Carcinogenesis (London) 19862,6-DINITROTOLUENE• mutagenic - Positive mutation assay: Morphological Transform (rat orl)
RTECS®- Cell Biology and Toxicology 19912,6-DINITROTOLUENE• mutagenic - Positive mutation assay: DNA Inhibition (rat ipr)
• mutagenic - Positive mutation assay: Unscheduled DNA Synthesis (rat oth)
RTECS®- Developments in Toxicology and Environtal Science 19772,6-DINITROTOLUENE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS®- Environmental and Molecular Mutagenesis 20042,6-DINITROTOLUENE• mutagenic - Positive mutation assay: DNA Damage (rat tes)
RTECS®- Journal of Toxicology and Environmental Health 19832,6-DINITROTOLUENE• mutagenic - Positive mutation assay: DNA Adduct (rat orl)
• mutagenic - Positive mutation assay: other mutation test systems (rat orl)
RTECS®- Mutation Research 19932,6-DINITROTOLUENE• mutagenic - Positive mutation assay: DNA Adduct (rat ipr)
RTECS®- National Technical Information Service 2,6-DINITROTOLUENE• mutagenic - Positive mutation assay: Cytogenetic Analysis (rat orl)
RTECS®- National Technical Information Service 2,6-DINITROTOLUENE• skin - Primary skin irritant (rabbit )
RTECS®- Personal Communication from J 19822,6-DINITROTOLUENE• mutagenic - Positive mutation assay: DNA Damage (rat lvr)
RTECS®- Sangyo Igaku 19872,6-DINITROTOLUENE• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )



references

government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Amer Conf of Gov't Industrial Hygienists - CarcinogensACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org.
EPA Clean Water Act - Priority Pollutants
European Union - Banned or Restricted in CosmeticsEC (European Commission of the European Union). 1999-2006. Enterprise Directorate-General Pharmaceuticals and Cosmetics. The rules governing cosmetic products in the European Union, Volume 1, "Cosmetics legislation."
Int'l Agency for Research on Cancer (IARC) - CarcinogensIARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
EPA Toxic Release Inventory PBTsEPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
California EPA Proposition 65California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
Scorecard.org Toxicity InformationAgency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
Scorecard.org Toxicity InformationProposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.
Scorecard.org Toxicity InformationProposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS®- Cancer Letters (Shannon, Ireland) 1990RTECS®- Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 52,13,1990
RTECS®- Carcinogenesis (London) 1982RTECS®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 3,241,1982
RTECS®- Carcinogenesis (London) 1984RTECS®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 5,231,1984
RTECS®- Carcinogenesis (London) 1986RTECS®- Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 7,1797,1986
RTECS®- Cell Biology and Toxicology 1991RTECS®- Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 7,111,1991
RTECS®- Developments in Toxicology and Environtal Science 1977RTECS®- Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued 2,249,1977
RTECS®- Environmental and Molecular Mutagenesis 2004RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 44,179,2004
RTECS®- Journal of Toxicology and Environmental Health 1983RTECS®- Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 11,555,1983
RTECS®- Mutation Research 1993RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 301,79,1993
RTECS®- National Technical Information Service RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-A062-015
RTECS®- National Technical Information Service RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. AD-B011-150
RTECS®- Personal Communication from J 1982RTECS®- Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982 26OCT1982
RTECS®- Sangyo Igaku 1987RTECS®- Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 29,34,1987

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