| Score |  Data: Fair |
| Health Concern | HIGH |
| Product Types | anti-itch / rash cream; pain relief |
| Made by | Lanacane by Combe Inc. |
| Data last updated | August 2007 |
| how to read the score | |
 |
| ||||||||||||||||||||
company policies | |
|---|---|
| Compact for Safe Cosmetics | Non-signer |
| Animal Testing Policy | UNKNOWN: As of EWG's last review, this company is not certified by PETA or Leaping Bunny as not testing on animals. |
Label Information | |
|---|---|
| Ingredients from packaging: | ACTIVE INGREDIENTS: BENZETHONIUM CHLORIDE 0.2%; BENZOCAINE 6%. INACTIVE INGREDIENTS: WATER; STEARIC ACID; GLYCERIN; GLYCERYL STEARATE SE; SULFATED CASTOR OIL; SODIUM BORATE; TRIETHANOLAMINE; ETHOXYDIGLYCOL; METHYLPARABEN; PROPYLPARABEN; ISOPROPYL ALCOHOL; FRAGRANCE; ZINC PYRITHIONE; CHLOROTHYMOL; ZINC OXIDE; ALOE; TOCOPHERYL ACETATE; CHOLECALCIFEROL; CORN OIL; DIOCTYL SODIUM SULFOSUCCINATE; RETINYL PALMITATE. |
| Directions from packaging: | Adults and children 2 years and older: Clean the affected area and apply a small amount to affected area not more than 1 to 3 times daily; may be covered with a sterile bandage. Children under 2 years: Ask a doctor. |
Where to purchase | ||
|---|---|---|
| Shop with EWG on Amazon.com | Amazon.com product page | |
ingredients |
concerns | score |
|---|---|---|
| FRAGRANCE | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous | Data: Fair |
| RETINYL PALMITATE (VITAMIN A PALMITATE) | Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes, Use restrictions | Data: Fair |
| BENZOCAINE | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Use restrictions (meets restrictions and warnings based on EWG review of company data) |  Data: Fair |
| SODIUM BORATE | Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Use restrictions |  Data: Fair |
| METHYLPARABEN | Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes | Data: Fair |
| PROPYLPARABEN | Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Ecotoxicology | Data: Fair |
| TRIETHANOLAMINE | Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (NITROSAMINES-in the presence of nitrosating agents), Use restrictions | Data: Good |
| TOCOPHERYL ACETATE | Cancer, Allergies/immunotoxicity, Ecotoxicology, Contamination concerns (HYDROQUINONE) |  Data: Fair |
| ISOPROPYL ALCOHOL | Cancer, Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) | Data: Good |
| ZINC PYRITHIONE | Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Ecotoxicology, Use restrictions | Data: Fair |
| ZINC OXIDE | Developmental/reproductive toxicity, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Ecotoxicology |  Data: Good |
| CHOLECALCIFEROL | Organ system toxicity (non-reproductive), Occupational hazards, Use restrictions |  Data: Fair |
| BENZETHONIUM CHLORIDE (Active Ingredient) | Use restrictions |  Data: Fair |
| DIOCTYL SODIUM SULFOSUCCINATE | Organ system toxicity (non-reproductive) | Data: Fair |
| ETHOXYDIGLYCOL | Organ system toxicity (non-reproductive) | Data: Limited |
| STEARIC ACID | Ecotoxicology | Data: Fair |
| 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL CHLOROTHYMOL | Use restrictions | Data: Limited |
| ALOE BARBADENSIS (ALOE VERA) | Developmental/reproductive toxicity, Use restrictions | Data: Limited |
| GLYCERIN | None Identified |  Data: Fair |
| SULFATED CASTOR OIL | None Identified | Data: Limited |
| ZEA MAYS (CORN) OIL | None Identified | Data: Fair |
| GLYCERYL STEARATE SE | None Identified | Data: Limited |
| WATER | Innocuous | Data: Robust |
Cancer**Listed below are cancer concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show tumor formation at high doses | TOCOPHERYL ACETATE | |
| Not likely to be carcinogenic in humans | STEARIC ACID | |
| One or more in vitro tests non-mammalian cells show positive mutation results | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| Cancer - not classifiable/not likely to be human carcinogen | ISOPROPYL ALCOHOL, TRIETHANOLAMINE | |
Developmental/reproductive toxicity**Listed below are developmental/reproductive toxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | RETINYL PALMITATE (VITAMIN A PALMITATE), ZINC OXIDE | |
| One or more animal studies show reproductive effects at moderate doses | ALOE BARBADENSIS (ALOE VERA) | |
| Limited evidence of developmental toxicity | ISOPROPYL ALCOHOL | |
| One or more animal studies show any effects at low doses | PROPYLPARABEN | |
| Limited evidence of reproductive toxicity | SODIUM BORATE | |
Neurotoxicity**Listed below are neurotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | ISOPROPYL ALCOHOL | |
| Moderate evidence of human neurotoxicity | FRAGRANCE | |
Endocrine disruption**Listed below are endocrine disruption concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more studies show weak endocrine disruption | METHYLPARABEN | |
| One or more studies show significant wildlife and the environment disruption | PROPYLPARABEN | |
Allergies/immunotoxicity**Listed below are allergies/immunotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more human case studies show possible immune effects | PROPYLPARABEN, METHYLPARABEN | |
| One or more animal studies show any effects at very low doses | ZINC OXIDE | |
| Limited evidence of immune system toxicity | ZINC PYRITHIONE | |
| Human skin toxicant - strong evidence | TRIETHANOLAMINE, TOCOPHERYL ACETATE | |
| Known human immune system toxicant | BENZOCAINE, FRAGRANCE | |
Persistence and bioaccumulation**Listed below are persistence and bioaccumulation concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Persistent or bioaccumulative and moderate to high toxicity concern in humans | ZINC PYRITHIONE | |
| Not suspected to be bioaccumulative | ZINC OXIDE, ZEA MAYS (CORN) OIL, WATER, TRIETHANOLAMINE, TOCOPHERYL ACETATE, SULFATED CASTOR OIL, SODIUM BORATE, RETINYL PALMITATE (VITAMIN A PALMITATE), PROPYLPARABEN, ISOPROPYL ALCOHOL, GLYCERIN | |
| Not suspected to be persistent | STEARIC ACID | |
| Not suspected to be bioaccumulative | BENZETHONIUM CHLORIDE | |
| Not suspected to be persistent | CHOLECALCIFEROL, GLYCERYL STEARATE SE, METHYLPARABEN, BENZOCAINE, 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL | |
Organ system toxicity (non-reproductive)**Listed below are organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Classified as a low human health priority | ZEA MAYS (CORN) OIL, WATER, SULFATED CASTOR OIL, GLYCERIN | |
| Classified as not expected to be potentially toxic or harmful | TOCOPHERYL ACETATE, STEARIC ACID, RETINYL PALMITATE (VITAMIN A PALMITATE), GLYCERYL STEARATE SE, CHOLECALCIFEROL, BENZOCAINE, BENZETHONIUM CHLORIDE, ALOE BARBADENSIS (ALOE VERA), 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL | |
| Classified as expected to be toxic or harmful | ZINC PYRITHIONE, TRIETHANOLAMINE, SODIUM BORATE, DIOCTYL SODIUM SULFOSUCCINATE | |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | ISOPROPYL ALCOHOL, ETHOXYDIGLYCOL | |
| Limited evidence of sense organ toxicity | PROPYLPARABEN, METHYLPARABEN | |
| Possible human respiratory toxicant | ZINC OXIDE | |
Miscellaneous**Listed below are miscellaneous concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | products for use around the mouth; products for use on the lips; products for use on skin | CHOLECALCIFEROL |
| Occupational hazards related to handling | ISOPROPYL ALCOHOL | |
| Prohibited for use in food | SODIUM BORATE | |
| Ingredient not fully labeled - identity unknown | FRAGRANCE | |
Multiple, additive exposure sources**Listed below are multiple, additive exposure sources concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | ZINC OXIDE, TRIETHANOLAMINE, TOCOPHERYL ACETATE, STEARIC ACID, RETINYL PALMITATE (VITAMIN A PALMITATE), PROPYLPARABEN, METHYLPARABEN, GLYCERYL STEARATE SE, ISOPROPYL ALCOHOL, GLYCERIN, CHOLECALCIFEROL, DIOCTYL SODIUM SULFOSUCCINATE, ETHOXYDIGLYCOL, ALOE BARBADENSIS (ALOE VERA) | |
| Used in food or as an additive with limited or no toxicity information available | SODIUM BORATE | |
Ecotoxicology**Listed below are ecotoxicology concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation) | TOCOPHERYL ACETATE | |
| Suspected to be an environmental toxin and be persistent or bioaccumulative | ZINC PYRITHIONE | |
| Uncertain environmental toxin and uncertain persistent or bioaccumulative | SULFATED CASTOR OIL, RETINYL PALMITATE (VITAMIN A PALMITATE), CHOLECALCIFEROL | |
| Suspected to be an environmental toxin | STEARIC ACID | |
| Not suspected to be an environmental toxin | ZEA MAYS (CORN) OIL, WATER, TRIETHANOLAMINE, SODIUM BORATE, PROPYLPARABEN, METHYLPARABEN, ISOPROPYL ALCOHOL, GLYCERIN, GLYCERYL STEARATE SE, BENZOCAINE, BENZETHONIUM CHLORIDE, ALOE BARBADENSIS (ALOE VERA), 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL | |
| Wildlife and environmental toxicity | ZINC OXIDE | |
Irritation (skin, eyes, or lungs)**Listed below are irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Classified as irritant | ISOPROPYL ALCOHOL | |
Data gaps**Listed below are data gaps concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Missing safety data noted by cosmetic industry review | 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL, ALOE BARBADENSIS (ALOE VERA) | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | TOCOPHERYL ACETATE, RETINYL PALMITATE (VITAMIN A PALMITATE), STEARIC ACID, PROPYLPARABEN, GLYCERYL STEARATE SE, ETHOXYDIGLYCOL, METHYLPARABEN, DIOCTYL SODIUM SULFOSUCCINATE | |
| Not assessed for safety in cosmetics by industry panel | ZINC PYRITHIONE, SULFATED CASTOR OIL, ISOPROPYL ALCOHOL, GLYCERIN, FRAGRANCE, CHOLECALCIFEROL, BENZOCAINE | |
Occupational hazards**Listed below are occupational hazards concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to very low doses | CHOLECALCIFEROL | |
Biochemical or cellular level changes**Listed below are biochemical or cellular level changes concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease. | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| Interferes with gene expresion | METHYLPARABEN | |
Use restrictions**Listed below are use restrictions concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | 4-CHLORO-5 METHYL-2-(1-METHYLETHYL)-PHENOL | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | BENZETHONIUM CHLORIDE, CHOLECALCIFEROL, SODIUM BORATE, RETINYL PALMITATE (VITAMIN A PALMITATE), BENZETHONIUM CHLORIDE, BENZETHONIUM CHLORIDE, ZINC PYRITHIONE | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | BENZOCAINE | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | ALOE BARBADENSIS (ALOE VERA), BENZETHONIUM CHLORIDE, SODIUM BORATE, TRIETHANOLAMINE | |
