| Score |  Data: Limited |
| Health Concern | HIGH |
| Product Type | personal cleansing |
| Made by | Vagisil by Combe Inc. |
| Data last updated | February 2010 |
| how to read the score | |
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company policies | |
|---|---|
| Compact for Safe Cosmetics | Non-signer |
| Animal Testing Policy | UNKNOWN: As of EWG's last review, this company is not certified by PETA or Leaping Bunny as not testing on animals. |
Label Information | |
|---|---|
| Ingredients from packaging: | Active Ingredient: Pramoxine Hydrochloride 1% w/w. Inactive Ingredients: Water, Polysorbate 20, Glycerin, PEG-7 Glyceryl Cocoate, TEA-Cocoyl Glutamate, Disodium Cocoamphodiacetate, Retinyl Palmitate, Cholecalciferol, Zea Mays (Corn) Oil, Aloe Barbadensis Leaf Juice, Tocopheryl Acetate, Methylparaben, Propylparaben, Disodium EDTA, Fragrance. |
| Directions from packaging: | Adults and Children 12 Years and Older: Unfold towelette and gently pat or wipe external vaginal area from front to back. Use each towelette only once and then throw away. Apply to affected area not more than 3 to 4 times daily. Children Under 12 Years: Consult a doctor. |
| Warnings from packaging: | For external use only. Avoid contact with eyes. Stop use and ask doctor if condition worsens, or if symptoms persist for more than 7 days, or clear up and occur again within a few days. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. |
Where to purchase | ||
|---|---|---|
| Shop with EWG on Amazon.com | Amazon.com product page | |
ingredients |
concerns | score |
|---|---|---|
| FRAGRANCE | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous |  Data: Fair |
| PEG-7 GLYCERYL COCOATE | Organ system toxicity (non-reproductive), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE), Use restrictions |  Data: Limited |
| RETINYL PALMITATE (VITAMIN A PALMITATE) | Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes, Use restrictions | Data: Fair |
| METHYLPARABEN | Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes |  Data: Fair |
| PROPYLPARABEN | Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Ecotoxicology | Data: Fair |
| TOCOPHERYL ACETATE | Cancer, Allergies/immunotoxicity, Ecotoxicology, Contamination concerns (HYDROQUINONE) | Data: Fair |
| POLYSORBATE-20 | Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |  Data: Fair |
| CHOLECALCIFEROL | Organ system toxicity (non-reproductive), Occupational hazards, Use restrictions | Data: Fair |
| DISODIUM EDTA | Developmental/reproductive toxicity, Enhanced skin absorption |  Data: Fair |
| ALOE BARBADENSIS (ALOE VERA) GEL ALOE BARBADENSIS LEAF JUICE | Developmental/reproductive toxicity, Use restrictions | Data: Limited |
| TEA COCOYL GLUTAMATE | None Identified |  Data: None |
| PRAMOXINE HCL PRAMOXINE HYDROCHLORIDE 1% W/W (Active Ingredient) | None Identified |  Data: Limited |
| GLYCERIN | None Identified | Data: Fair |
| ZEA MAYS (CORN) OIL | None Identified | Data: Fair |
| DISODIUM COCOAMPHODIACETATE | None Identified | Data: Limited |
| WATER | Innocuous | Data: Robust |
Cancer**Listed below are cancer concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests non-mammalian cells show positive mutation results | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| One or more animal studies show tumor formation at high doses | TOCOPHERYL ACETATE | |
Developmental/reproductive toxicity**Listed below are developmental/reproductive toxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| One or more animal studies show developmental effects at high doses | DISODIUM EDTA | |
| One or more animal studies show any effects at moderate doses | ALOE BARBADENSIS (ALOE VERA) GEL | |
| One or more animal studies show any effects at low doses | PROPYLPARABEN | |
Neurotoxicity**Listed below are neurotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Moderate evidence of human neurotoxicity | FRAGRANCE | |
Endocrine disruption**Listed below are endocrine disruption concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more studies show weak endocrine disruption | METHYLPARABEN | |
| One or more studies show significant wildlife and the environment disruption | PROPYLPARABEN | |
Allergies/immunotoxicity**Listed below are allergies/immunotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more human case studies show possible immune effects | PROPYLPARABEN | |
| Human skin toxicant - strong evidence | TOCOPHERYL ACETATE | |
| One or more human case studies show possible immune effects | METHYLPARABEN | |
| Known human immune system toxicant | FRAGRANCE | |
Organ system toxicity (non-reproductive)**Listed below are organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Limited evidence of sense organ toxicity | PEG-7 GLYCERYL COCOATE | |
| Classified as a low human health priority | ZEA MAYS (CORN) OIL, POLYSORBATE-20, WATER, GLYCERIN | |
| Classified as not expected to be potentially toxic or harmful | TOCOPHERYL ACETATE, RETINYL PALMITATE (VITAMIN A PALMITATE), PRAMOXINE HCL, DISODIUM EDTA, DISODIUM COCOAMPHODIACETATE, CHOLECALCIFEROL | |
| Limited evidence of sense organ toxicity | PROPYLPARABEN, METHYLPARABEN | |
Miscellaneous**Listed below are miscellaneous concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | products for use around the mouth; products for use on the lips; products for use on skin | CHOLECALCIFEROL |
| Ingredient not fully labeled - identity unknown | FRAGRANCE | |
Ecotoxicology**Listed below are ecotoxicology concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation) | TOCOPHERYL ACETATE | |
| Uncertain environmental toxin and uncertain persistent or bioaccumulative | RETINYL PALMITATE (VITAMIN A PALMITATE), CHOLECALCIFEROL | |
| Not suspected to be an environmental toxin | ZEA MAYS (CORN) OIL, WATER, PROPYLPARABEN, PRAMOXINE HCL, POLYSORBATE-20, METHYLPARABEN, GLYCERIN, DISODIUM EDTA, DISODIUM COCOAMPHODIACETATE | |
Data gaps**Listed below are data gaps concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Safety assessment was based on related chemical | PEG-7 GLYCERYL COCOATE | |
| Missing safety data noted by cosmetic industry review | ALOE BARBADENSIS (ALOE VERA) GEL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | POLYSORBATE-20, DISODIUM EDTA, TOCOPHERYL ACETATE, PROPYLPARABEN, RETINYL PALMITATE (VITAMIN A PALMITATE), METHYLPARABEN, DISODIUM COCOAMPHODIACETATE | |
| Not assessed for safety in cosmetics by industry panel | TEA COCOYL GLUTAMATE, PRAMOXINE HCL, GLYCERIN, FRAGRANCE, CHOLECALCIFEROL | |
Occupational hazards**Listed below are occupational hazards concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to very low doses | CHOLECALCIFEROL | |
Biochemical or cellular level changes**Listed below are biochemical or cellular level changes concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Interferes with gene expresion | METHYLPARABEN | |
| Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease. | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
Use restrictions**Listed below are use restrictions concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | RETINYL PALMITATE (VITAMIN A PALMITATE), CHOLECALCIFEROL | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | ALOE BARBADENSIS (ALOE VERA) GEL, PEG-7 GLYCERYL COCOATE | |
