| Score |  Data: Limited |
| Health Concern | HIGH |
| Product Type | anti-itch / rash cream |
| Made by | Vagisil by Combe Inc. |
| Data last updated | February 2008 |
| how to read the score | |
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company policies | |
|---|---|
| Compact for Safe Cosmetics | Non-signer |
| Animal Testing Policy | UNKNOWN: As of EWG's last review, this company is not certified by PETA or Leaping Bunny as not testing on animals. |
Label Information | |
|---|---|
| Ingredients from packaging: | Active Ingredients: Benzocaine (20%), Resorcinol (3%). Inactive Ingredients: Water, Mineral Oil, Cetyl Alcohol, Propylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Isopropyl Palmitate, Aloe Barbadensis Leaf Juice, Tocopheryl Acetate, Retinyl Palmitate, Zea Mays (Corn) Oil, Cholecalciferol, Lanolin Alcohol, Fragrance, Methylparaben, Carbomer, Isopropyl Myristate, Isopropyl Stearate, Sodium Sulfite, Triethanolamine, Trisodium HEDTA. |
| Directions from packaging: | Adults and children 12 years and older: apply a fingertip amount (approximately 1 inch strip) to affected area not more than 3-4 times daily. Children under 12 years: consult a doctor. |
| Warnings from packaging: | For external use only. Avoid contact with eyes. Stop use and ask a doctor if condition worsens, or if symptoms persist for more than 7 days, or clear up and occur again within a few days. Do not apply over large areas of the body. Keep out of reach of children. If swallowed, get medical help or contact a poison control center right away. |
Where to purchase | ||
|---|---|---|
| Shop with EWG on Amazon.com | Amazon.com product page | |
ingredients |
concerns | score |
|---|---|---|
| RESORCINOL (Active Ingredient) | Cancer, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Ecotoxicology, Irritation (skin, eyes, or lungs), Occupational hazards, Use restrictions |  Data: Fair |
| FRAGRANCE | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous | Data: Fair |
| RETINYL PALMITATE (VITAMIN A PALMITATE) | Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes, Use restrictions | Data: Fair |
| BENZOCAINE | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Use restrictions (meets restrictions and warnings based on EWG review of company data) |  Data: Fair |
| PEG-100 STEARATE | Organ system toxicity (non-reproductive), Ecotoxicology, Data gaps, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE) |  Data: Limited |
| METHYLPARABEN | Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes |  Data: Fair |
| TRIETHANOLAMINE | Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (NITROSAMINES-in the presence of nitrosating agents), Use restrictions | Data: Good |
| TOCOPHERYL ACETATE | Cancer, Allergies/immunotoxicity, Ecotoxicology, Contamination concerns (HYDROQUINONE) |  Data: Fair |
| LANOLIN ALCOHOL | Allergies/immunotoxicity, Organ system toxicity (non-reproductive) | Data: Limited |
| MINERAL OIL | Allergies/immunotoxicity, Organ system toxicity (non-reproductive) | Data: Fair |
| CHOLECALCIFEROL | Organ system toxicity (non-reproductive), Occupational hazards, Use restrictions | Data: Fair |
| PROPYLENE GLYCOL | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Use restrictions | Data: Fair |
| ISOPROPYL STEARATE | Irritation (skin, eyes, or lungs), Data gaps |  Data: Limited |
| CETYL ALCOHOL | Organ system toxicity (non-reproductive), Ecotoxicology | Data: Limited |
| GLYCERYL MONOSTEARATE GLYCERYL STEARATE | Ecotoxicology | Data: Limited |
| ISOPROPYL MYRISTATE | Irritation (skin, eyes, or lungs) | Data: Fair |
| SODIUM SULFITE | Allergies/immunotoxicity | Data: Fair |
| ALOE BARBADENSIS (ALOE VERA) GEL ALOE BARBADENSIS LEAF JUICE | Developmental/reproductive toxicity, Use restrictions | Data: Limited |
| ZEA MAYS (CORN) OIL | None Identified |  Data: Fair |
| CARBOMER | None Identified | Data: Fair |
| ISOPROPYL PALMITATE | None Identified | Data: Fair |
| TRISODIUM HEDTA | Enhanced skin absorption | Data: Limited |
| WATER | Innocuous | Data: Robust |
Cancer**Listed below are cancer concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests non-mammalian cells show positive mutation results | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| One or more animal studies show tumor formation at high doses | TOCOPHERYL ACETATE | |
| Cancer - not classifiable/not likely to be human carcinogen | TRIETHANOLAMINE | |
| Cancer - limited evidence | RESORCINOL | |
Developmental/reproductive toxicity**Listed below are developmental/reproductive toxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Not likely to be a any toxicant in humans | PROPYLENE GLYCOL | |
| One or more animal studies show reproductive effects at high doses | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| One or more animal studies show any effects at moderate doses | ALOE BARBADENSIS (ALOE VERA) GEL | |
Neurotoxicity**Listed below are neurotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Moderate evidence of human neurotoxicity | FRAGRANCE | |
Endocrine disruption**Listed below are endocrine disruption concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more studies show weak endocrine disruption | METHYLPARABEN | |
| endocrine - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | RESORCINOL | |
Allergies/immunotoxicity**Listed below are allergies/immunotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| One or more human case studies show possible immune effects | METHYLPARABEN | |
| Human immune system toxicant - moderate evidence | SODIUM SULFITE | |
| Limited evidence of skin and immune system toxicity | PROPYLENE GLYCOL | |
| Human skin toxicant - strong evidence | TOCOPHERYL ACETATE, TRIETHANOLAMINE, RESORCINOL, LANOLIN ALCOHOL, MINERAL OIL | |
| Known human immune system toxicant | FRAGRANCE, BENZOCAINE | |
Organ system toxicity (non-reproductive)**Listed below are organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Classified as a low human health priority | ZEA MAYS (CORN) OIL, WATER, SODIUM SULFITE | |
| Classified as medium human health priority | LANOLIN ALCOHOL | |
| Classified as not expected to be potentially toxic or harmful | TRISODIUM HEDTA, TOCOPHERYL ACETATE, RETINYL PALMITATE (VITAMIN A PALMITATE), ISOPROPYL PALMITATE, ISOPROPYL MYRISTATE, GLYCERYL MONOSTEARATE, CHOLECALCIFEROL, CARBOMER, BENZOCAINE | |
| Classified as expected to be toxic or harmful | TRIETHANOLAMINE, PROPYLENE GLYCOL, MINERAL OIL, CETYL ALCOHOL | |
| Limited evidence of sense organ toxicity | PEG-100 STEARATE, METHYLPARABEN, RESORCINOL | |
Miscellaneous**Listed below are miscellaneous concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | products for use around the mouth; products for use on the lips; products for use on skin | CHOLECALCIFEROL |
| Ingredient not fully labeled - identity unknown | FRAGRANCE | |
Ecotoxicology**Listed below are ecotoxicology concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation) | TOCOPHERYL ACETATE | |
| Uncertain environmental toxin and uncertain persistent or bioaccumulative | RETINYL PALMITATE (VITAMIN A PALMITATE), CHOLECALCIFEROL | |
| Suspected to be an environmental toxin | PEG-100 STEARATE, GLYCERYL MONOSTEARATE, CETYL ALCOHOL | |
| Not suspected to be an environmental toxin | TRISODIUM HEDTA, ZEA MAYS (CORN) OIL, WATER, TRIETHANOLAMINE, SODIUM SULFITE, METHYLPARABEN, LANOLIN ALCOHOL, ISOPROPYL PALMITATE, ISOPROPYL MYRISTATE, CARBOMER, BENZOCAINE | |
| Wildlife and environmental toxicity | RESORCINOL | |
Irritation (skin, eyes, or lungs)**Listed below are irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | ISOPROPYL STEARATE, ISOPROPYL MYRISTATE |
| Classified as skin irritant | PROPYLENE GLYCOL, RESORCINOL | |
Data gaps**Listed below are data gaps concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Safety assessment was based on related chemical | PROPYLENE GLYCOL, PEG-100 STEARATE | |
| Missing safety data noted by cosmetic industry review | ALOE BARBADENSIS (ALOE VERA) GEL, ISOPROPYL STEARATE | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | TRISODIUM HEDTA, TOCOPHERYL ACETATE, SODIUM SULFITE, PEG-100 STEARATE, RETINYL PALMITATE (VITAMIN A PALMITATE), RESORCINOL, METHYLPARABEN, ISOPROPYL PALMITATE, LANOLIN ALCOHOL, ISOPROPYL STEARATE, ISOPROPYL MYRISTATE, GLYCERYL MONOSTEARATE, CETYL ALCOHOL, CARBOMER | |
| Not assessed for safety in cosmetics by industry panel | MINERAL OIL, FRAGRANCE, CHOLECALCIFEROL, BENZOCAINE | |
Occupational hazards**Listed below are occupational hazards concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to very low doses | CHOLECALCIFEROL | |
| Allowed workplace exposures restricted to low doses | RESORCINOL | |
Biochemical or cellular level changes**Listed below are biochemical or cellular level changes concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease. | RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| Interferes with gene expresion | METHYLPARABEN | |
Use restrictions**Listed below are use restrictions concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances. |
||
|---|---|---|
| type of concern | product conditions | ingredient(s) |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | CHOLECALCIFEROL | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | BENZOCAINE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit) | RESORCINOL, RETINYL PALMITATE (VITAMIN A PALMITATE) | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | RESORCINOL, ALOE BARBADENSIS (ALOE VERA) GEL, PROPYLENE GLYCOL, TRIETHANOLAMINE | |
