Ivarest Anti-Itch Cream, Maximum Strength, Medicated (2008 formulation)

Ingredient Concerns

Ingredient	Concerns	Score
BENZYL ALCOHOL	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Use restrictions	Data: Fair
PETROLATUM	Contamination concerns (PAHS), Organ system toxicity (non-reproductive), Use restrictions	Data: Fair
PEG-4	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE), Organ system toxicity (non-reproductive)	Data: Fair
POLYSORBATE-60	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE), Organ system toxicity (non-reproductive)	Data: Limited
LANOLIN ALCOHOL	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)	Data: Limited
PROPYLENE GLYCOL	Enhanced skin absorption, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Organ system toxicity (non-reproductive), Use restrictions	Data: Fair
IRON OXIDES BLACK IRON OXIDE	Enhanced skin absorption, Organ system toxicity (non-reproductive), Persistence and bioaccumulation	Data: Fair
CASTOR OIL	Enhanced skin absorption, Data gaps, Developmental/reproductive toxicity, Irritation (skin, eyes, or lungs)	Data: Fair
CAMPHOR	Use restrictions	Data: Fair
BENTONITE	Use restrictions	Data: Fair
BENZETHONIUM CHLORIDE	Use restrictions	Data: Limited
CALAMINE (Active Ingredient)	Ecotoxicology, Organ system toxicity (non-reproductive)	Data: Limited
DIPHENHYDRAMINE HCL DIPHENHYDRAMINE HYDROCHLORIDE (2% W/W) (Active Ingredient)	Ecotoxicology	Data: Fair
MENTHOL	Multiple, additive exposure sources	Data: Fair
MAGNESIUM ALUMINUM SILICATE	Organ system toxicity (non-reproductive)	Data: Limited
SORBITAN STEARATE	Ecotoxicology	Data: Limited
PVP	Organ system toxicity (non-reproductive)	Data: Fair
GOLDEN BROWN DYE	None Identified	Data: None
POLYGLYCERYL-3 DIISOSTEARATE	None Identified	Data: None
HYDROXYETHYLCELLULOSE	None Identified	Data: Fair
LANOLIN OIL	None Identified	Data: Limited
WATER	Innocuous	Data: Robust

Animal Testing Policies

Label Information

Ingredients from packaging:

Active Ingredients: Calamine (14% W/W), Diphenhydramine Hydrochloride (2% W/W). Inactive Ingredients: Bentonite, Benzethonium Chloride, Benzyl Alcohol, Black Iron Oxide, Camphor, Castor Oil, Golden Brown Dye, Hydroxyethylcellulose, Lanolin Oil, Lanolin Alcohol, Magnesium Aluminum Silicate, Menthol, PEG-4, Petrolatum, Polyglyceryl-3 Diisostearate, Polysorbate 60, Propylene Glycol, Purified Water, PVP, Sorbitan Stearate, and Yellow Iron Oxide.

Directions from packaging:

As soon as possible after exposure, cleanse affected are with soap and water. Gently pat dry. Apply Ivarest liberally to form a layer you can not see through. Adults and Children 2 Years and Older: Apply to affected area not more than 3 to 4 times daily. Children Under 2 Years of Age: Consult a doctor. Avoid contact with clothing. Ivarest may stain certain fabrics.

Warnings from packaging:

Do not use on chicken pox or measles, on large areas of the body, more often then directed or with any other product containing diphenhydramine, even one taken by mouth. For external use only. When using this product avoid contact with the eyes. Stop use and ask a doctor if condition worsens, or symptoms persist for more than 7 days or clear up and occur again within a few days. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

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