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BUTADIENE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
 
Allergies & immunotoxicity
 
 
Use restrictions
 
 
Other HIGH concerns: Organ system toxicity (non-reproductive); Other LOW concerns: Occupational hazards

Possible impurity in: ISOBUTANE (840 products), BUTANE (305 products), PETROLEUM DISTILLATES (100 products), HYDROGENATED POLYISOBUTANE (10 products), see all ingredients | products

Synonym(s): 1,3-BUTADIENE (ACGIH:OSHA) ; ALPHA,GAMMA-BUTADIENE; BIETHYLENE; BIVINYL; BUTA-1,3-DIEEN (DUTCH) ; BUTA-1,3-DIEN (GERMAN) ; BUTA-1,3-DIENE; BUTADIEEN (DUTCH) ; BUTADIEN (POLISH) ; BUTADIENE (OSHA) ; BUTADIENE-1,3

Cancer

Concern Reference
Known human carcinogenEuropean Union - Classification & Labelling
Known human carcinogenEPA Integrated Risk Information System (IRIS)
Known human carcinogenInt'l Agency for Research on Cancer (IARC) - Carcinogens
Known human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenEuropean Union - Classification & Labelling
Possible human carcinogenAmer Conf of Gov't Industrial Hygienists - Carcinogens
Possible human carcinogenInt'l Agency for Research on Cancer (IARC) - Carcinogens
Possible human carcinogenNTP - Tumor Induction in Mammary Gland
Possible human carcinogenCalifornia EPA Proposition 65
Cancer - strong evidenceProposition 65 List of Carcinogens (July 2004) can be obtained from http://www
Limited evidence of carcinogenicityNIOSH Occupational Carcinogens
Possible mutagenEuropean Union - Classification & Labelling
One or more human case studies show possible cancer findingsNTP - Tumor Induction in Mammary Gland
Cancer - limited evidenceSilent Spring's Mammary Carcinogens Reviews Database

Developmental/reproductive toxicity

Concern Reference
Possible human developmental toxicantCalifornia EPA Proposition 65
Human developmental toxicant - strong evidenceProposition 65 List of Carcinogens (July 2004) can be obtained from http://www
Human reproductive toxicant - strong evidenceProposition 65 List of Carcinogens (July 2004) can be obtained from http://www
Limited evidence of reproductive toxicityNational Library of Medicine HazMap

Organ system toxicity (non-reproductive)

Concern Reference
Known human respiratory toxicantEPA Hazardous Air Pollutants
Limited evidence of cardiovascular or blood toxicityUS EPA, Air Risk Information Support Center
Limited evidence of respiratory toxicityUS EPA, Air Risk Information Support Center
Limited evidence of sense organ toxicityUS EPA, Air Risk Information Support Center
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Miscellaneous

Concern Reference
Occupational hazards related to handlingEuropean Union - Classification & Labelling

Data gaps

Concern Reference
3,487 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

ACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
NTP (National Toxicology Program) 2006. Chemicals Associated with Site-Specific Tumor Induction in Mammary Gland.
NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Proposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.
Proposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.
Proposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.
Rudel RA, KR Attfield, JN Schifano and JG Brody. Chemicals Causing Mammary Gland Tumors in Animals Signal New Directions for Epidemiology, Chemicals Testing, and Risk Assessment for Breast Cancer Prevention. CANCER Supplement. 2007 Jun 15;109(12):2635-2666.
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer