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NITROSAMINES


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
 
Allergies & immunotoxicity
 
 
Other LOW concerns: Organ system toxicity (non-reproductive)

Possible impurity in: TRIETHANOLAMINE (4,833 products), LECITHIN (4,271 products), COCAMIDOPROPYL BETAINE (4,169 products), STEARALKONIUM HECTORITE (2,495 products), SODIUM PCA (1,694 products), AMINOMETHYL PROPANOL (1,428 products), COCAMIDE MEA (1,333 products), COCAMIDE DEA (599 products), SODIUM LAUROYL SARCOSINATE (561 products), HYDROGENATED LECITHIN (456 products), see all ingredients | products

Synoym(s): DEN (MUTAGEN) ; DENA; DIAETHYLNITROSAMIN (GERMAN) ; DIETHYL NITROSAMINE; DIETHYLNITROSAMIDE; DIETHYLNITROSAMINE; DIETHYLNITROSOAMINE; ETHANAMINE, N-ETHYL-N-NITROSO- (9CI) ; ETHYLAMINE, N-NITROSODI-; N,N-DIETHYLNITROSAMINE; N-DIETHYLNITROSAMINE

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Cancer

Concern Reference
Possible human carcinogenEPA Integrated Risk Information System (IRIS)
Possible human carcinogenInt'l Agency for Research on Cancer (IARC) - Carcinogens
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenCalifornia EPA Proposition 65
Cancer - strong evidenceProposition 65 List of Carcinogens (July 2004) can be obtained from http://www

Developmental/reproductive toxicity

Concern Reference
Limited evidence of reproductive toxicityUS EPA
Limited evidence of developmental toxicityUS EPA

Organ system toxicity (non-reproductive)

Concern Reference
Limited evidence of gastrointestinal or liver toxicityNational Library of Medicine HazMap
Limited evidence of sense organ toxicityLock, E
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs

Data gaps

Concern Reference
11,833 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
Lock, E.A., and E. Harpur. Toxicology of Sensory System: A Perspective. Human and Experimental Toxicology. 11(6): 442-448. 1992. (Table 1: Chemicals that induce olfactory lesions in experimental animals by either inhalation and/or non-inhalation routes).
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Proposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.
US EPA. Roadmaps to Sources of Information on Chemicals Listed in the Emergency Planning Community and Community Right-to-Know Act (Also Known as SARA Title 3), Section 313 Toxic Release Inventory (for Microcomputers). (Report Number EPADFDK92040). 1991. Data file distributed in 2 diskettes by Office of Pollution, Prevention, and Toxics, Environmental Protection Agency, Washington, DC. NOTE: Datasource no longer being maintained by EPA; not currently available online.
US EPA. Roadmaps to Sources of Information on Chemicals Listed in the Emergency Planning Community and Community Right-to-Know Act (Also Known as SARA Title 3), Section 313 Toxic Release Inventory (for Microcomputers). (Report Number EPADFDK92040). 1991. Data file distributed in 2 diskettes by Office of Pollution, Prevention, and Toxics, Environmental Protection Agency, Washington, DC. NOTE: Datasource no longer being maintained by EPA; not currently available online., Jankovic, J. A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer