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Score:
Data available:
 
Fair

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ESTRONE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 

Possible impurity in: PLACENTAL PROTEIN (1 products), PLACENTA ENZYMES (1 products), PLACENTAL EXTRACT (1 products), PLACENTAL LIPIDS, BOVINE , PLACENTAL EXTRACT, HUMAN, LYOPHILIZED , PLACENTAL EXTRACT, HUMAN, LIQUID , HUMAN PLACENTAL PROTEIN HYDROLYSATE , BOVINE PLACENTAL PROTEIN , BOVINE PLACENTAL EXTRACT , ANIMAL PLACENTAL EXTRACT , see all ingredients | products

Synonym(s): OESTRON; 1,3,5 (10) -ESTRATRIEN-3-OL-17-ONE; 1,3,5 (10) -OESTRATRIEN-3-OL-17-ONE; 1,3,5-ESTRATRIEN-3-OL-17-ONE; 1,3,5-OESTRATRIEN-3-OL-17-ONE; AQUACRINE; CRINOVARYL; CRISTALLOVAR; CRYSTOGEN; DESTRONE; DISYNFORMON

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Cancer

Concern Reference
Possible human carcinogenCalifornia EPA Proposition 65
Cancer - limited evidenceSilent Spring's Mammary Carcinogens Reviews Database

Persistence and bioaccumulation

Concern Reference
Persistent, bioaccumulative in wildlifeOSPAR PBTs - Substances of Possible Concern
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature

Data gaps

Concern Reference
13,255 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
Emerging PBTs from peer-reviewed literature
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
OSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
Rudel RA, KR Attfield, JN Schifano and JG Brody. Chemicals Causing Mammary Gland Tumors in Animals Signal New Directions for Epidemiology, Chemicals Testing, and Risk Assessment for Breast Cancer Prevention. CANCER Supplement. 2007 Jun 15;109(12):2635-2666.

About the Skin Deep® ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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