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THIOCTIC ACID
Score
Data: Fair
CAS1077-28-7
facial moisturizer/ treatment (27 products)
anti-aging (18 products)
moisturizer (5 products)
around-eye cream (5 products)
mask (3 products)
Show all 54 products that contain THIOCTIC ACID.
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THIOCTIC ACID


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Antioxidant

Synonym(s): 1,2-DITHIOLANE-3-PENTANOIC ACID; 1,2-DITHIOLANE-3-VALERIC ACID; 5- (DITHIOLAN-3-YL) VALERIC ACID; A-LIPOIC ACID; 1,2DITHIOLANE3PENTANOIC ACID, (+/) ; 1,2-DITHIOLANE-3-PENTANOIC ACID, (+-) - (9CI) ; DL-1,2-DITHIOLAN-3-VALERIANSAEURE (GERMAN) ; DL-1,2-DITHIOLANE 3-VALERIC ACID; DL-6,8-THIOCTIC ACID; DL-6-THIOCTIC ACID; DL-ALPHA-LIPOIC ACID

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
2,693 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be persistent    Environment Canada Domestic Substance List
show more

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
Environment Canada Domestic Substance List1,2-DITHIOLANE-3-PENTANOIC ACID, (±)-,,,,,,,,,

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Archives of Toxicology 2002THIOCTIC ACID• biochemical - Multiple enzyme effects (rat TDLo)
• kidney or renal system - Other changes (rat TDLo)
• biochemical - Other proteins (rat TDLo)
RTECS®- Arzneimittel-Forschung 1971THIOCTIC ACID• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Toxicology Letters 2005THIOCTIC ACID• biochemical - Lipids, including transport (rat TDLo)
• kidney or renal system - Other changes (rat TDLo)
RTECS®- Toxicology 2005THIOCTIC ACID• biochemical - Multiple enzyme effects (rat TDLo)
RTECS®- Toxicology 2005THIOCTIC ACID• biochemical - Effect on mitochondrial function (rat TDLo)
• cardiovascular - Other changes (rat TDLo)
• biochemical - TCS cycle (rat TDLo)

references
government/industry list/academic study reference
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
RTECS®- Archives of Toxicology 2002 [shown for informational purposes only]RTECS®- Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- 76,437,2002
RTECS®- Arzneimittel-Forschung 1971 [shown for informational purposes only]RTECS®- Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- 21,284,1971
RTECS®- Toxicology Letters 2005 [shown for informational purposes only]RTECS®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 160,1,2005
RTECS®- Toxicology 2005 [shown for informational purposes only]RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 210,25,2005
RTECS®- Toxicology 2005 [shown for informational purposes only]RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 215,108,2005

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