Health Concerns of the Ingredient:
Overall Hazard
Developmental &
reproductive toxicity
Allergies & immunotoxicity
About POLOXAMER 124: Poloxamer 124 is a polyoxyethylene, polyoxypropylene block polymer.
Function(s): Surfactant - Emulsifying Agent; Surfactant - Solubilizing Agent
Persistence and bioaccumulation
| Concern |
Reference |
|---|
| Persistent or bioaccumulative and moderate to high toxicity concern in humans | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Organ system toxicity (non-reproductive)
| Concern |
Reference |
|---|
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List |
| Classified as medium human health priority | Environment Canada Domestic Substance List |
Ecotoxicology
| Concern |
Reference |
|---|
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern |
Reference |
|---|
| Missing safety data noted by cosmetic industry review | Cosmetic Ingredient Review Assessments |
| Safety assessment was based on related chemical | Cosmetic Ingredient Review Assessments |
| 524 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | NLM PubMed |
Multiple, additive exposure sources
| Concern |
Reference |
|---|
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Data Sources
| CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. |
Products Containing the Ingredient
About the ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.
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