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Data available:
 
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PAPAIN

Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
 
Use restrictions
 
 
Other HIGH concerns: Irritation (skin, eyes, or lungs); Other LOW concerns: Ecotoxicology

About PAPAIN: Papain is a proteolytic enzyme isolated from the latex of the green fruit and leaves of Caricapapaya.

Function(s): Hair Conditioning Agent; Lytic Agent; Skin-Conditioning Agent - Miscellaneous; ANTISTATIC; SKIN CONDITIONING

Synonym(s): PAPAIN; PAPAINASE; PAPAINE; ARBUZ; CAROID; NEMATOLYT; PAPAYOTIN; SUMMETRIN; TROMASIN; VEGETABLE PEPSIN; VELARDON

Allergies/immunotoxicity

Concern Reference
Human immune and respiratory toxicant or allergen - strong evidence (only for )Association of Occupational and Environmental Clinics
Limited evidence of immune system toxicity or allergies (only for products that may be aerosolized (airborne))European Union - Classification & Labelling
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritantEuropean Union - Classification & Labelling

Ecotoxicology

Concern Reference
Uncertain environmental toxin and uncertain persistent or bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
9,255 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Multiple, additive exposure sources

Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Data Sources

AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer