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Data available:
 
Fair

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DIMETHYL PHTHALATE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
 
 
Use restrictions
 
 
Other HIGH concerns: Organ system toxicity (non-reproductive), Persistence and bioaccumulation; Other LOW concerns: Data gaps, Ecotoxicology

About DIMETHYL PHTHALATE: Dimethyl Phthalate is a diester of methyl alcohol and phthalic acid.

Function(s): Fragrance Ingredient; Plasticizer; Solvent; FILM FORMING; MASKING; PLASTICISER

Synonym(s): 1,2-BENZENEDICARBOXYLIC ACID, DIMETHYL ESTER; 1,2BENZENEDICARBOXYLIC ACID, DIMETHYL ESTER; DIMETHYL 1,2-BENZENEDICARBOXYLATE; DIMETHYL ESTER 1,2-BENZENEDICARBOXYLIC ACID; DIMETHYL ESTER PHTHALIC ACID; DIMETHYLPHTHALATE; DMP; PHTHALIC ACID, DIMETHYL ESTER; 1,2-BENZENEDICARBOXYLIC ACID, DIMETHYL ESTER; AVOLIN; DIMETHYL 1,2-BENZENEDICARBOXYLATE

Organ system toxicity (non-reproductive)

Concern Reference
Known human respiratory toxicantEPA Hazardous Air Pollutants
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Limited evidence of respiratory toxicityUS EPA, Air Risk Information Support Center
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

Concern Reference
Limited evidence of reproductive toxicityNational Library of Medicine HazMap

Persistence and bioaccumulation

Concern Reference
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Allergies/immunotoxicity

Concern Reference
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Ecotoxicology

Concern Reference
Wildlife and environmental toxicityEPA Clean Water Act - Priority Pollutants
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Cancer

Concern Reference
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsEPA Integrated Risk Information System (IRIS)

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Insufficient data to determine safetyEPA Integrated Risk Information System (IRIS)
Safety assessment was based on related chemicalCosmetic Ingredient Review Assessments
2,804 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html

About the Skin Deep® ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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