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Score:
Data available:
 
Fair

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DIETHANOLAMINE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
 
 

About DIETHANOLAMINE: Diethanolamine is an aliphatic amine.

Function(s): pH Adjuster

Synonym(s): 2,2'-DIHYDROXYDIETHYLAMINE; 2,2'-IMINOBISETHANOL; 2,2'-IMINODIETHANOL; DEA (EWG) ; ETHANOL, 2,2 IMINOBIS; N,N-DIETHANOLAMINE; 2,2'-DIHYDROXYDIETHYLAMINE; 2,2'-IMINOBISETHANOL; 2,2'-IMINODIETHANOL; 2- (2-HYDROXYETHYLAMINO) ETHANOL; BIS (2-HYDROXYETHYL) AMINE

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCosIng
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Allergies/immunotoxicity

Concern Reference
Human immune and respiratory toxicant or allergen - strong evidence (only for )Association of Occupational and Environmental Clinics
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Cancer

Concern Reference
Possible human carcinogenCalifornia EPA (California Environmental Protection Agency)
Limited evidence of carcinogenicityWorld Health Organization, International Agency for Research on Cancer
Cancer - limited evidenceNational Toxicology Program
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsInt'l Agency for Research on Cancer (IARC) - Carcinogens

Organ system toxicity (non-reproductive)

Concern Reference
Known human respiratory toxicantEPA Hazardous Air Pollutants
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as toxic or harmful (only for products for use around the mouth; products for use on the lips)European Union - Classification & Labelling
Limited evidence of respiratory toxicityUS EPA, Air Risk Information Support Center
Limited evidence of sense organ toxicityUS EPA, Air Risk Information Support Center
Limited evidence of cardiovascular or blood toxicityCalifornia EPA, Office of Environmental Health Hazard Assessment
One or more animal studies show effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to low dosesEuropean Union - Classification & Labelling

Developmental/reproductive toxicity

Concern Reference
One or more animal studies show neurodevelopmental effects at moderate dosesCraciunescu CN, Wu R, Zeisel SH

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritantEuropean Union - Classification & Labelling
Limited evidence of skin irritationNational Library of Medicine HazMap

Data gaps

Concern Reference
2,147 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Contamination concerns

Impurity Score
NITROSAMINES
Data: Fair

Data Sources

AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
California EPA (California Environmental Protection Agency). 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
California EPA (California Environmental Protection Agency). 2012. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity. Updated July 2012.
California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document 'Determination of Noncancer Chronic Reference Exposure Levels'. Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (http://www.oehha.ca.gov/air/chronic_rels/AllChrels.html, plus draft CRELS proposed through March 2004 (http://www.oehha.ca.gov/air/chronic_rels/index.html., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
Craciunescu CN, Wu R, Zeisel SH. "Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus." FASEB J. 2006 Aug;20(10):1635-40.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2001-2002 for Possible Listing in the Report on Carcinogens, Eleventh Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC.http://ntp-server.niehs.nih.gov/NewHomeRoc/11thConsideration.html National Toxicology Program. Summary for Agents, Substances, Mixtures or Exposure Circumstances to be Reviewed in 2004-2005 for Possible Listing in the Report on Carcinogens, Twelfth Edition. NTP Board of Scientific Counselors, NTP, Research Triangle Park, NC. http://ntp-server.niehs.nih.gov/NewHomeRoc/12thConsideration.html
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html
US EPA, Air Risk Information Support Center. Health Effects Notebook for Hazardous Air Pollutants. http://www.epa.gov/ttnatw01/hlthef/hapindex.html, A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html
World Health Organization, International Agency for Research on Cancer. IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php

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