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BENZISOTHIAZOLINONE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
 

About BENZISOTHIAZOLINONE: Benzisothiazolinone is a heterocyclic compound.

Function(s): Preservative; ANTIMICROBIAL

Synonym(s): 1,2-BENZISOTHIAZOL-3 (2H) -ONE; 1,2BENZISOTHIAZOL3 (2H) ONE; 1,2-BENZISOTHIAZOLIN-3-ONE; BENZISOTHIAZOLIN-3-ONE; PROXEL PL; PROXEL XL 2

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsEuropean SCCS

Allergies/immunotoxicity

Concern Reference
Possible human sensitizer toxicant or allergenUS Environmental Protection Agency (EPA)
Limited evidence of immune system toxicity or allergies (only for products for use on skin)European Union - Classification & Labelling
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to low dosesEuropean Union - Classification & Labelling

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritantEuropean Union - Classification & Labelling

Organ system toxicity (non-reproductive)

Concern Reference
Classified as toxic or harmful (only for products for use around the mouth; products for use on the lips)European Union - Classification & Labelling
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Wildlife and environmental toxicityEuropean Union - Classification & Labelling
Wildlife and environmental toxicityUS Environmental Protection Agency (EPA)
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
130 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European SCCS. 2012. Opinion on Benzisothiazolinone. COLIPA n° P96, June 2012. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_099.pdf
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
US Environmental Protection Agency (EPA). 2005. Reregistration Eligibility Decision (RED) for Benzisothiazoline-3-one.
US Environmental Protection Agency (EPA). 2005. Reregistration Eligibility Decision (RED) for Benzisothiazoline-3-one.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer