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image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
Developmental &
reproductive toxicity
Other HIGH concerns: Persistence and bioaccumulation; Other LOW concerns: Ecotoxicology, Endocrine disruption

Function(s): Fragrance Ingredient; MASKING


Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - CosIng

Persistence and bioaccumulation

Concern Reference
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Endocrine disruption

Concern Reference
Associated with endocrine disruptionBitsch N, Dudas C, Körner W, Failing K, Biselli S, Rimkus G, Brunn H
Associated with endocrine disruptionSeinen W, Lemmen JG, Pieters RH, Verbruggen EM, VanderBurg B
Associated with endocrine disruptionSchreurs RH, Quaedackers ME, Seinen W, van der Burg B
Associated with endocrine disruptionSchreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B


Concern Reference
One or more animal studies show photosensitizing or allergenic effects at high dosesEuropean Union Risk Assessment Report


Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
222 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data Sources

Bitsch N, Dudas C, Körner W, Failing K, Biselli S, Rimkus G, Brunn H. 2002. Estrogenic activity of musk fragrances detected by the E-screen assay using human mcf-7 cells. Arch Environ Contam Toxicol. 43(3):257-64.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Emerging PBTs from peer-reviewed literature
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
European Union Risk Assessment Report. 2008. for 1-(5,6,7,8-TETRAHYDRO-3,5,5,6,8,8-HEXAMETHYL-2- NAPHTHYL)ETHAN-1-ONE (AHTN) CAS No: 1506-02-1 or 21145-77-7.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Schreurs RH, Quaedackers ME, Seinen W, van der Burg B. 2002. Transcriptional activation of estrogen receptor ERalpha and ERbeta by polycyclic musks is cell type dependent. Toxicol Appl Pharmacol. 183(1): 1-9.
Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B. 2005. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 83(2): 264-72.
Seinen W, Lemmen JG, Pieters RH, Verbruggen EM, VanderBurg B. 1999. AHTN and HHCB show weak estrogenic – but no uterotrophic activity. Toxicol. Lett. 111(1-2): 161–168.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer