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VITAMIN E SUCCINATE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 
Use restrictions
 
 
Other LOW concerns: Data gaps, Ecotoxicology

About VITAMIN E SUCCINATE: Tocopheryl Succinate is an ester of Tocopherol (q.v.) and succinic acid.

Function(s): Antioxidant

Synonym(s): TOCOPHERYL SUCCINATE, ALPHA-TOCOPHERYL HYDROGEN SUCCINATE; BUTANEDIOIC ACID,; D-ALPHA-TOCOPHERYL SUCCINATE; DL-ALPHA-TOCOPHERYL SUCCINATE; MONO [3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2- (4,8,12-TRIMETHYLTRIDECYL) -2HG1-BENZOPYRAN-6-YL] ESTER; VITAMINE E SUCCINATE; (+) -ALPHA-TOCOPHERYL SUCCINATE; ALPHA-TOCOPHEROL HEMISUCCINATE; ALPHA-TOCOPHEROL, SUCCINATE (6CI) ; ALPHA-TOCOPHERYL ACID SUCCINATE; ALPHA-TOCOPHERYL SUCCINATE

Cancer

Concern Reference
One or more animal studies show tumor formation at high dosesConstantinides P, Harkey M
One or more animal studies show tumor formation at high dosesNitta Y, Kamiya K, Tanimoto M, Sadamoto S, Niwa O, Yokoro K

Ecotoxicology

Concern Reference
Uncertain environmental toxin and uncertain persistent or bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
369 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Multiple, additive exposure sources

Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data Sources

CIR
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Constantinides P, Harkey M. 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Nitta Y, Kamiya K, Tanimoto M, Sadamoto S, Niwa O, Yokoro K. 1991. Induction of transplantable tumors by repeated subcutaneous injections of natural and synthetic vitamin E in mice and rats. Jpn J Cancer Res 82(5): 511-7.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer