TROMETHAMINE
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About the ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.
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Function/use(s): Fragrance Ingredient; pH Adjuster; BUFFERING; MASKING
About TROMETHAMINE: Tromethamine is an aliphatic compound.
Synonym(s): 2-AMINO-2- (HYDROXYMETHYL) -1,3-PROPANEDIOL; 1,3-PROPANEDIOL, 2-AMINO-2- (HYDROXYMETHYL) -; THAM; TRIS (HYDROXYMETHYL) AMINO METHANE; 2-AMINO-2- (HYDROXYMETHYL) - 1,3-PROPANEDIOL; 1,3PROPANEDIOL, 2AMINO2 (HYDROXYMETHYL) ; TRIS; TRIS, FREE BASE; TROMETAMOL; 2-AMINO-2- (HYDROXYMETHYL) -1,3-PROPANEDIOL; 2-AMINO-2- (HYDROXYMETHYL) PROPANE-1,3-DIOL; 2-AMINO-2-METHYLOL-1,3-PROPANEDIOL
Data gaps |
| type of concern |
product conditions |
reference |
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| Not assessed for safety in cosmetics by industry panel |
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| 5,470 studies in PubMed science library may include information on the toxicity of this chemical
see search results ->
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PubMed |
Ecotoxicology |
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product conditions |
reference |
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| Not suspected to be an environmental toxin |
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Environment Canada Domestic Substance List |
Organ system toxicity (non-reproductive) |
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product conditions |
reference |
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| Classified as not expected to be potentially toxic or harmful |
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Environment Canada Domestic Substance List |
Persistence and bioaccumulation |
| type of concern |
product conditions |
reference |
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| Not suspected to be persistent |
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Environment Canada Domestic Substance List |
| show more |
| Not suspected to be bioaccumulative |
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Environment Canada Domestic Substance List | |
Government, industry, academic studies and classifications |
| government/industry list/academic study |
appears on list as |
classification(s) |
| Environment Canada Domestic Substance List | 1,3-PROPANEDIOL, 2-AMINO-2-(HYDROXYMETHYL)- | ,,,,,,,,, |
| IFRA Fragrance Ingredient List | 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL | reported as used in fragrance compounds in 2008 |
Other RTECS® classifications [shown for informational purposes only] |
| government/industry list/academic study |
appears on list as |
classification(s) |
| RTECS®- Acta Biologica et Medica Germanica 1966 | TROMETHAMINE | • broad systemic - Broad systemic toxicity (mouse LD50)
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| RTECS®- Bollettino Chimico Farmaceutico 1971 | TROMETHAMINE | • broad systemic - Broad systemic toxicity (rat LD50)
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| RTECS®- Drugs in Japan (Ethical Drugs) 1990 | TROMETHAMINE | • broad systemic - Broad systemic toxicity (rat LD50)
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| RTECS®- Journal of Industrial Hygiene and Toxicology 1940 | TROMETHAMINE | • brain, nervous system, or behavioral effect - Coma (rabbit LDLo)
• brain, nervous system, or behavioral effect - Muscle weakness (rabbit LDLo)
• brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (rabbit LDLo)
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references |
| government/industry list/academic study
| reference
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| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| RTECS®- Acta Biologica et Medica Germanica 1966 [shown for informational purposes only] | RTECS®- Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. 17,217,1966 |
| RTECS®- Bollettino Chimico Farmaceutico 1971 [shown for informational purposes only] | RTECS®- Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- 110,653,1971 |
| RTECS®- Drugs in Japan (Ethical Drugs) 1990 [shown for informational purposes only] | RTECS®- Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) -,419,1990 |
| RTECS®- Journal of Industrial Hygiene and Toxicology 1940 [shown for informational purposes only] | RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 22,315,1940 |
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