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Score:
Data available:
 
Fair

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TRICLOSAN


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
 

About TRICLOSAN: Triclosan is an antibacterial agent and preservative used in personal care and home-cleaning products; persistent in the environment and may be associated with endocrine (hormonal) toxicity.

Possible impurity in: CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT (1,011 products), CITRUS PARADISI (GRAPEFRUIT) SEED EXTRACT (40 products), see all ingredients | products

Function(s): Cosmetic Biocide; Deodorant Agent; Preservative

Synonym(s): 2,4,4'-TRICHLORO-2'-HYDROXY DIPHENYL ETHER; 5-CHLORO-2- (2,4-DICHLOROPHENOXY) - PHENOL; 5-CHLORO-2- (2,4-DICHLOROPHENOXY) PHENOL; PHENOL, 5-CHLORO-2- (2,4-DICHLOROPHENOXY) -; PHENOL, 5CHLORO2 (2,4DICHLOROPHENOXY) ; 2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER; 5-CHLORO-2- (2,4-DICHLOROPHENOXY) PHENOL; CH 3565; IRGASAN; IRGASAN DP300; PHENOL, 5-CHLORO-2- (2,4-DICHLOROPHENOXY) -

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)Japan's Standards for Cosmetics

Endocrine disruption

Concern Reference
One or more studies show endocrine disruption at very low dosesVeldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006
One or more studies show moderate endocrine disruptionZorrilla LM, Gibson EK, Jeffay SC, et al

Allergies/immunotoxicity

Concern Reference
One or more human case studies show possible immune or allergenic effectsRees Clayton EM, Todd M, Beam Dowd J, Aiello AE

Persistence and bioaccumulation

Concern Reference
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature

Organ system toxicity (non-reproductive)

Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as potentially toxic or harmfulCherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, et al

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritantEuropean Union - Classification & Labelling

Ecotoxicology

Concern Reference
Wildlife and environmental toxicityEuropean Union - Classification & Labelling
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
1,875 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Contamination concerns

Impurity Score
CHLOROFORM
Data: Fair
DIOXINS
Data: Fair

Data Sources

AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, et al. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35): 14158-14163.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Emerging PBTs from peer-reviewed literature
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Rees Clayton EM, Todd M, Beam Dowd J, Aiello AE. 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental Health Perspectives 119(3), 390-6.
Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006. "The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development," Aquat Toxicol. 2006 Dec 1;80(3):217-27. Tata JR. "Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone." Ann Endocrinol (Paris). 1998;59(6):433-42.
Zorrilla LM, Gibson EK, Jeffay SC, et al. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences: an official journal of the Society of Toxicology 107(1), 56-64.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer