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TRICLOSAN
Score
Data: Fair
CAS3380-34-5
antiperspirant/ deodorant (men's) (76 products)
liquid hand soap (70 products)
facial cleanser (41 products)
toothpaste (38 products)
acne treatment (29 products)
Show all 459 products that contain TRICLOSAN.
Possible impurity in: CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT (780 products), CITRUS PARADISI (GRAPEFRUIT) SEED EXTRACT (66 products), see all ingredients | products
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TRICLOSAN


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictionsyes
Contamination concerns: CHLOROFORM, DIOXINS
Other HIGH concerns: Irritation (skin, eyes, or lungs)
Other MODERATE concerns: Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
Other LOW concerns: Ecotoxicology, Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Cosmetic Biocide; Deodorant Agent; Preservative

About TRICLOSAN: Triclosan is an antibacterial agent and preservative used in personal care and home-cleaning products; persistent in the environment and may be associated with endocrine (hormonal) toxicity.

Synonym(s): 5-CHLORO-2- (2,4-DICHLOROPHENOXY) PHENOL; PHENOL, 5-CHLORO-2- (2,4-DICHLOROPHENOXY) -; 2,4,4'-TRICHLORO-2'-HYDROXY DIPHENYL ETHER; 5-CHLORO-2- (2,4-DICHLOROPHENOXY) - PHENOL; PHENOL, 5CHLORO2 (2,4DICHLOROPHENOXY) ; 2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER; 5-CHLORO-2- (2,4-DICHLOROPHENOXY) PHENOL; CH 3565; IRGASAN; IRGASAN DP300; PHENOL, 5-CHLORO-2- (2,4-DICHLOROPHENOXY) -

Use restrictions

type of concern product conditions reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)   Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics   Canada - Prohibited and Restricted Cosmetics Ingredients

Endocrine disruption

type of concern product conditions reference
One or more studies show endocrine disruption at very low doses    Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as expected to be toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Persistent, bioaccumulative in wildlife    Emerging PBTs from peer-reviewed literature

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
Classified as irritant    European Union - Classification & Labelling

Ecotoxicology

type of concern product conditions reference
Suspected to be an environmental toxin and be persistent or bioaccumulative    Environment Canada Domestic Substance List
show more

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
1,525 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
European Union - Classification & LabellingTRICLOSANXi; R36/38; N; R50-53
Association of Occupational and Environmental ClinicsTRICLOSAN• o
Canada - Prohibited and Restricted Cosmetics IngredientsTRICLOSANRestricted
Environment Canada Domestic Substance ListTRICLOSANY-Categorization,,,Y-Persistent,Y-Bioaccumulative,Y-AquaticTox,,,,
IFRA Fragrance Ingredient ListTRICLOSANreported as used in fragrance compounds in 2008
National Library of Medicine HazMapTRICLOSAN
Japan's Standards for CosmeticsTRICHLOROHYDROXYDIPHENYLETHER (TRICLOSAN)Japan - restricted for use in cosmetics (concentration limit)
Emerging PBTs from peer-reviewed literaturePHENOL, 5CHLORO2(2,4DICHLOROPHENOXY)Identified as an potential emerging PBT in the scientific literature
Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006TRICLOSANAffects thyroid hormone-associated gene expression and disrupts postembryonic development. Findings on the control of amphibian metamorphosis enhance our understanding of the regulation of postembryonic development by thyroid hormone in mammals and other

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977TRICLOSAN• skin - Primary skin irritant ( human )
RTECS®- "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J 1970TRICLOSAN• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Eisei Shikenjo Hokoku 1987TRICLOSAN• reproductive - Fetal death (rat TDLo)
RTECS®- Industrial Medicine and Surgery 1969TRICLOSAN• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981TRICLOSAN• mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis )
RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981TRICLOSAN• mutagenic - Positive mutation assay: DNA repair (Bacillus subtilis )
RTECS®- Yakkyoku 1977TRICLOSAN• broad systemic - Broad systemic toxicity (mouse LD50)
• skin - Primary skin irritant (rabbit )
RTECS®- Yakkyoku 1977TRICLOSAN• skin - Primary skin irritant (rabbit )

references
government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
Canada - Prohibited and Restricted Cosmetics IngredientsHealth Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Japan's Standards for CosmeticsJapan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
Emerging PBTs from peer-reviewed literatureEmerging PBTs from peer-reviewed literature
Open scientific literatureVeldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC, 2006. "The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development," Aquat Toxicol. 2006 Dec 1;80(3):217-27. Tata JR. "Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone." Ann Endocrinol (Paris). 1998;59(6):433-42.
RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 [shown for informational purposes only]RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 -,127,1977
RTECS®- "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J 1970 [shown for informational purposes only]RTECS®- "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70 6,245,1968/1970
RTECS®- Eisei Shikenjo Hokoku 1987 [shown for informational purposes only]RTECS®- Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- (105),28,1987
RTECS®- Industrial Medicine and Surgery 1969 [shown for informational purposes only]RTECS®- Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. 38,64,1969
RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981 [shown for informational purposes only]RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan). (Nippon Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104, Japan) V.10- 15,243,1981
RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan) 1981 [shown for informational purposes only]RTECS®- Journal of SCCJ (Society of Cosmetic Chemists of Japan). (Nippon Keshohin Gijutsushakai, c/o Shiseido, 7-5-5 Ginza, Chuo-ku, Tokyo 104, Japan) V.10- 1976- 15,243,1981
RTECS®- Yakkyoku 1977 [shown for informational purposes only]RTECS®- Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- 28,985,1977
RTECS®- Yakkyoku 1977 [shown for informational purposes only]RTECS®- Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 28,985,1977

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