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Data: Fair

Toluene 2,5 Diamine Sulfate

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high), Ecotoxicology (low), and Occupational hazards (high)

SYNONYMS

● 1,4-BENZENEDIAMINE, 2-METHYL-, SULFATE
● 1,4-BENZENEDIAMINE, 2-METHYL-, SULFATE (1:1)
● 2,5-DIAMINOTOLUENE SULFATE
● 2-METHYL- SULFATE 1,4-BENZENEDIAMINE
● 2-METHYL-1,4-BENZENEDIAMINE SULFATE
● P-TOLUENEDIAMINE SULFATE
● SULFATE 1,4-BENZENEDIAMINE, 2-METHYL-
● TOLUENE-2,5-DIAMINE SULFATE

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient


Toluene-2, 5-Diamine Sulfate is a substituted aromatic amine salt.

Common concerns

See how this product scores for common concerns.

  • MODERATE
    Cancer
  • HIGH
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • HIGH
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

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hair color and bleaching116 products
toners/astringents1 products
hair treatment/serum1 products
mask1 products

Use restrictions

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CONCERN REFERENCE
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyOpen scientific literature
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyOpen scientific literature
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyCosIng
Determined safe for use in cosmetics, subject to concentration or use limitations - anyCTFA International Cosmetic Ingredient Dictionary and Handbook

Allergies/immunotoxicity

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CONCERN REFERENCE
Known human any toxicant or allergenOpen scientific literature
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergiesCPS&Q - Classification & Labelling
Limited evidence of any toxicity or allergiesOpen scientific literature

Occupational hazards

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CONCERN REFERENCE
Allowed workplace exposures restricted to low dosesCPS&Q - Classification & Labelling

Cancer

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CONCERN REFERENCE
Limited evidence of carcinogenicityOpen scientific literature
Cancer - limited evidenceCTFA International Cosmetic Ingredient Dictionary and Handbook
Not likely to be carcinogenic in humansOpen scientific literature

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as toxic or harmfulCPS&Q - Classification & Labelling
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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CONCERN REFERENCE
Wildlife and environmental toxicityCPS&Q - Classification & Labelling
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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CONCERN REFERENCE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Insufficient data to determine safetyCosmetic Ingredient Review Assessments
37 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Persistence and bioaccumulation

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CONCERN REFERENCE
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • Open scientific/peer reviewed literature
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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