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TOLUENE-2,5-DIAMINE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
 
Other HIGH concerns: Occupational hazards; Other MODERATE concerns: Organ system toxicity (non-reproductive); Other LOW concerns: Data gaps, Ecotoxicology

About TOLUENE-2,5-DIAMINE: Toluene-2, 5-Diamine is a substituted aromatic amine.

Function(s): Hair Colorant; HAIR DYEING

Synonym(s): 1,4-BENZENEDIAMINE, 2-METHYL-; 2,5-TOLUENEDIAMINE; 2-METHYL- 1,4-BENZENEDIAMINE; 2-METHYL-1,4-BENZENEDIAMINE; 2-METHYL-P-PHENYLENEDIAMINE; P-TOLUENEDIAMINE; 1,4-BENZENEDIAMINE, 2-METHYL-; 2,5-DIAMINOTOLUENE; 2-METHYL-1,4-BENZENEDIAMINE; 2-METHYL-P-PHENYLENEDIAMINE; 4-AMINO-2-METHYLANILINE

Allergies/immunotoxicity

Concern Reference
Known human toxicant or allergenScientific Committee on Consumer Safety (SCCS), OPINION ON Toluene-2,5-diamine and its sulfate, COLIPA n A5
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergies (only for products for use on skin)European Union - Classification & Labelling
Limited evidence of immune system toxicity or allergiesNordic Council of Ministers (Nordic Allergy Project)
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - CosIng
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Health Canada
Determined safe for use in cosmetics, subject to concentration or use limitations - CTFA International Cosmetic Ingredient Dictionary and Handbook

Cancer

Concern Reference
Cancer - limited evidenceCTFA International Cosmetic Ingredient Dictionary and Handbook
Cancer - not classifiable/not likely to be human carcinogenInt'l Agency for Research on Cancer (IARC) - Carcinogens

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to low dosesEuropean Union - Classification & Labelling

Organ system toxicity (non-reproductive)

Concern Reference
Classified as toxic or harmful (only for products for use around the mouth; products for use on the lips)European Union - Classification & Labelling

Ecotoxicology

Concern Reference
Wildlife and environmental toxicityEuropean Union - Classification & Labelling

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Insufficient data to determine safetyCosmetic Ingredient Review Assessments
72 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
Health Canada. 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2011.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991., Swedish National Chemicals Inspectorate. Labelling of chemical products, Swedish regulations and general advice with regard to the classification and labelling of chemical products hazardous to health, flammables and explosives. List of Allergenic Substances. National Chemicals Inspectorate, Solna, Sweden. 1987, 1990-1992.
Scientific Committee on Consumer Safety (SCCS), OPINION ON Toluene-2,5-diamine and its sulfate, COLIPA n A5. June 2012.

About the Skin Deep® ratings

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