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TOCOPHERYL ACETATE
Score
Data: Fair
CAS58-95-7
lipstick (871 products)
moisturizer (700 products)
facial moisturizer/ treatment (675 products)
anti-aging (587 products)
lip gloss (497 products)
Show all 6,710 products that contain TOCOPHERYL ACETATE.
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TOCOPHERYL ACETATE


image source: PubChem
Health concerns of ingredient
About the ratings
Canceryes
Developmental & reproductive toxicity no information
Allergies & immunotoxicityyes
Use restrictions no information
Contamination concerns: HYDROQUINONE
Other LOW concerns: Ecotoxicology, Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Antioxidant; Skin-Conditioning Agent - Miscellaneous; SKIN CONDITIONING

About TOCOPHERYL ACETATE: Tocopheryl acetate is a chemical compound that consists of acetic acid and tocopherol (vitamin E)

Synonym(s): 3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2- (4,8,12-TRIMETHYLTRIDECYL-2H-BENZOPYRAN-6-OL, ACETATE; D-A-TOCOPHERYL ACETATE; D-ALPHA-TOCOPHERYL ACETATE; DL-A -TOCOPHERYL ACETATE; DL-ALPHA-TOCOPHERYL ACETATE; VITAMIN E ACETATE; ACETATE 3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2- (4,8,12-TRIMETHYLTRIDECYL-2H-BENZOPYRAN-6-OL; TOCOPHEROL ACETATE; TOCOPHERYL ACETATE, DL-ALPHA; ALPHA-TOCOPHERYL ACETATE; DL-ALPHA TOCOPHERYL ACETATE

Allergies/immunotoxicity

type of concern product conditions reference
Human skin toxicant - strong evidence    Cosmetic Ingredient Review Assessments

Cancer

type of concern product conditions reference
One or more animal studies show tumor formation at high doses    Gensler HL, Aickin M, Peng YM, Xu M, 1996

Ecotoxicology

type of concern product conditions reference
Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation)    Environment Canada Domestic Substance List
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Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
1,707 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List
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Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusTOCOPHEROL ACETATE• DS/NUTR
• GRAS
• GMP - CFR182.5892; 182.8892
Cosmetic Ingredient Review AssessmentsTOCOPHERYL ACETATEQQQ01,QQQ11; I, M-, D-, R-, S, C-
FDA Everything Added to FoodALPHA-TOCOPHEROL ACETATE• ASP
Environment Canada Domestic Substance List2H-1-BENZOPYRAN-6-OL, 3,4-DIHYDRO-2,5,7,8-TETRAMETHYL- 2-(4,8,12-TRIMETHYLTRIDECYL)-, ACETATE, [2R-[2R(4R,8R)]]-,,Low-Health Priority,Y-Persistent,,U-AquaticTox,,,,
Gensler HL, Aickin M, Peng YM, Xu M, 1996TOCOPHERYL ACETATEtocopheryl acetate enhanced photocarcinogenesis in an animal study

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Cancer Letters (Shannon, Ireland) 1984TOCOPHERYL ACETATE• mutagenic - Positive mutation assay: DNA Damage (rat ipr)
RTECS®- Food and Chemical Toxicology 1986TOCOPHERYL ACETATE• liver - Changes in liver weight (rat TDLo)
• blood - Changes in other cell count (unspecified) (rat TDLo)
• blood - Pigmented or nucleated red blood cells (rat TDLo)
RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002TOCOPHERYL ACETATE• broad systemic - Broad systemic toxicity (rat LD50)
RTECS®- Japanese Journal of Cancer Research 1991TOCOPHERYL ACETATE• cancer - Tumors at site of application (rat TDLo)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Open scientific literatureGensler HL, Aickin M, Peng YM, Xu M. 1996. Importance of the form of topical vitamin E for prevention of photocarcinogenesis. Nutr Cancer 26(2): 183-91.
RTECS®- Cancer Letters (Shannon, Ireland) 1984 [shown for informational purposes only]RTECS®- Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 25,163,1984
RTECS®- Food and Chemical Toxicology 1986 [shown for informational purposes only]RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 24,1043,1986
RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002 [shown for informational purposes only]RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997- 21,51,2002
RTECS®- Japanese Journal of Cancer Research 1991 [shown for informational purposes only]RTECS®- Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- 82,511,1991

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