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TOCOPHEROL
Score
Data: Fair
CAS10191-41-0
moisturizer (1,162 products)
facial moisturizer/ treatment (971 products)
anti-aging (494 products)
lip balm (457 products)
lipstick (442 products)
Show all 7,482 products that contain TOCOPHEROL.
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TOCOPHEROL


image source: PubChem
Health concerns of ingredient
About the ratings
Canceryes
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: HYDROQUINONE
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Antioxidant; Fragrance Ingredient; Skin-Conditioning Agent - Miscellaneous;Skin-Conditioning Agent - Occlusive; SKIN CONDITIONING

About TOCOPHEROL: Tocopherols are a class of naturally occurring chemical compounds related to Vitamin E

Synonym(s): MIXED TOCOPHEROLS; NATURAL VITAMIN E; D-ALPHA-TOCOPHEROL; DL-A -TOCOP HEROL; DL-ALPHA-TOCOPHEROL; VITAMIN E; TOCOPHERYL; VITAMIN E OIL; (+-) -ALPHA-TOCOPHEROL; DL-ALPHA-TOCOPHEROL; EPHANYL

Cancer

type of concern product conditions reference
One or more animal studies show tumor formation at high doses    Constantinides P, Harkey M, 1985
show more

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
37,450 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as not expected to be potentially toxic or harmful    Environment Canada Domestic Substance List

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
FDA Food Additive StatusTOCOPHEROLS• PRES
• GRAS
• GMP - CFR182.3890; 184.1890
• DS/NUTR
• GRAS
• GMP - CFR182.5890; 182.8890
Cosmetic Ingredient Review AssessmentsTOCOPHEROLQQQ01,QQQ11; M-, D-, R-, I, C-
FDA Everything Added to FoodTOCOPHEROLS• ASP
Environment Canada Domestic Substance ListVITAMIN E,,,Y-Persistent,,,,,,
IFRA Fragrance Ingredient List2H-1-BENZOPYRAN-6-OL, 3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-reported as used in fragrance compounds in 2008
CIRTOCOPHEROLImpurity: hydroquinone
Roelandts, 1998TOCOPHEROLMay protect skin fibroblasts and keratinocytes further against UVB-induced cytoxic effects
Bissett, 1990TOCOPHEROLSome protection against skin wrinkling and tumour formation
Darr, 1996TOCOPHEROLSome protection against skin wrinkling and tumour formation
Roelandts, 1998TOCOPHEROLMay protect skin fibroblasts and keratinocytes further against UVB-induced cytoxic effects
Bissett, 1990TOCOPHEROLSome protection against skin wrinkling and tumour formation
Darr, 1996TOCOPHEROLSome protection against skin wrinkling and tumour formation
Constantinides P, Harkey M, 1985TOCOPHEROLSubcutaneously injection of Vitamin E induced formation of fast growing fibrosarcomata at the site of the injection
Nitta Y, Kamiya K, Tanimoto M, Sadamoto S, Niwa O, Yokoro K, 1991TOCOPHEROLInjection of Vitamin E in soya oil induced tumor formation at the site of injection

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Cancer Letters (Shannon, Ireland) 1984TOCOPHEROL• mutagenic - Positive mutation assay: DNA Damage (rat ipr)

references
government/industry list/academic study reference
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Impurities - Open Scientific LiteratureCIR
Open scientific literature{Roelandts, 1998}
Open scientific literature{Bissett, 1990}
Open scientific literature{Darr, 1996}
Open scientific literature{Roelandts, 1998}
Open scientific literature{Bissett, 1990}
Open scientific literature{Darr, 1996}
Open scientific literatureConstantinides P, Harkey M. 1985. Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil. Virchows Arch A Pathol Anat Histopathol 405(3): 285-97.
Open scientific literatureNitta Y, Kamiya K, Tanimoto M, Sadamoto S, Niwa O, Yokoro K. 1991. Induction of transplantable tumors by repeated subcutaneous injections of natural and synthetic vitamin E in mice and rats. Jpn J Cancer Res 82(5): 511-7.
RTECS®- Cancer Letters (Shannon, Ireland) 1984 [shown for informational purposes only]RTECS®- Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 25,163,1984

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