Government, industry, academic studies and classifications |
| government/industry list/academic study |
appears on list as |
classification(s) |
| CHE Toxicant and Disease Database | TITANIUM DIOXIDE | Immune suppression * - Limited |
| FDA Color Additive Status | TITANIUM DIOXIDE | Cosmetics: Y; Food: Y; Drugs: Y; Eye: Y |
| FDA Color Additive Status | TITANIUM DIOXIDE | Medical Device |
| FDA Everything Added to Food | TITANIUM DIOXIDE | • ASP |
| Environment Canada Domestic Substance List | TITANIUM OXIDE (TIO2) | Y-Categorization,Y-Human health,Moderate-Health Priority,Y-Persistent,,,,,, |
| CTFA International Cosmetic Ingredient Dictionary and Handbook | TITANIUM DIOXIDE | Color Additives - Exempt from Batch Certification by the U.S. Food and Drug Administration |
| IFRA Fragrance Ingredient List | TITANIUM OXIDE (TIO2) | reported as used in fragrance compounds in 2008 |
| National Library of Medicine HazMap | TITANIUM DIOXIDE | SD: No;PE: 15 mg/m3, total dust;TL: 10 mg/m3;ID: 5000 mg/m3;MA: 1.5 mg/m3, respirable fraction; |
| Int'l Agency for Research on Cancer (IARC) - Carcinogens | TITANIUM DIOXIDE | IARC GROUP 2B |
| NIOSH Occupational Carcinogens | TITANIUM DIOXIDE | NIOSH potential occupational carcinogens |
| Gamer, A, 2006 | TITANIUM DIOXIDE | The amounts of titanium found in the tape strips and skin preparations were in the order of the analytical determination limit. No Ti was found in the receptor fluid at any sampling time. |
| Opinion of the Scientific Committee on Cosmetic Products and non-food products intended for consumers concerning Titanium Dioxide, 2000 | TITANIUM DIOXIDE | SCCNFP review of Titanium Dioxide did not identify relevant in vivo reproductive/developmental toxicity studies |
| California EPA, Office of Environmental Health Hazard Assessment, 2004 | TITANIUM DIOXIDE | Cancer Hazards: suspected |
Other RTECS® classifications [shown for informational purposes only] |
| government/industry list/academic study |
appears on list as |
classification(s) |
| RTECS®- TLV/BEI,2005 | TITANIUM DIOXIDE | • occupationally related - ACGIH TLV (human TWA)
|
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 | TITANIUM DIOXIDE | • skin - Primary skin irritant ( human )
|
| RTECS®- Environmental and Molecular Mutagenesis 1993 | TITANIUM DIOXIDE | • mutagenic - Positive mutation assay: Micronucleus test (mouse ipr)
|
| RTECS®- Environmental Mutagen Society 37th Annual Meeting Abstracts 2006 | TITANIUM DIOXIDE | • mutagenic - Positive mutation assay: DNA Damage ( human lng)
|
| RTECS®- Mutation Research 1998 | TITANIUM DIOXIDE | • mutagenic - Positive mutation assay: Micronucleus test (hamster ovr)
|
| RTECS®- Mutation Research 1998 | TITANIUM DIOXIDE | • mutagenic - Positive mutation assay: Micronucleus test (hamster ovr)
|
| RTECS®- Toxicologist 2005 | TITANIUM DIOXIDE | • biochemical - Effect on inflammation or mediation of inflammation (rat TCLo)
• respiratory - Other changes (rat TCLo)
|
| RTECS®- Toxicologist 2005 | TITANIUM DIOXIDE | • cardiovascular - Regional or general arteriolar constriction (rat TDLo)
|
| RTECS®- Toxicologist 2002 | TITANIUM DIOXIDE | • respiratory - Other changes (rat TDLo)
|
| RTECS®- Toxicologist 2002 | TITANIUM DIOXIDE | • biochemical - Effect on inflammation or mediation of inflammation (rat TDLo)
• respiratory - Other changes (rat TDLo)
|
| RTECS®- Toxicology In Vitro 1987 | TITANIUM DIOXIDE | • mutagenic - Positive mutation assay: DNA Inhibition (hamster lng)
|
| RTECS®- Toxicology Letters 2003 | TITANIUM DIOXIDE | |
| RTECS®- United States Environmental Protection Agency, Office of Pesticides and Toxic Substances 1994 | TITANIUM DIOXIDE | • gastrointestinal - Hypermotility, diarrhea (rat TDLo)
|
references |
| government/industry list/academic study
| reference
|
| CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. |
| FDA Color Additive Status | FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006. |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| CTFA International Cosmetic Ingredient Dictionary and Handbook | CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| Int'l Agency for Research on Cancer (IARC) - Carcinogens | IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures). |
| NIOSH Occupational Carcinogens | NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html. |
| Open scientific literature | Gamer, A. O., E. Leibold, et al. (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307. |
| Open scientific literature | Opinion of the Scientific Committee on Cosmetic Products and non-food products intended for consumers concerning Titanium Dioxide. Colipa n° S75. Adopted by the SCCNFP during the 14th plenary meeting of 24 October 2000 |
| Scorecard.org Toxicity Information | California EPA, Office of Environmental Health Hazard Assessment. Prioritization Notices. http://www.oehha.org/prop65/CRNR_notices/state_listing/prioritization_notices/index.html. Chemicals on Candidate List for consideration under Proposition 65 due to high carcinogenicity concern (through March 2004). Chemicals under consideration for listing via the authoritative bodies mechanisms (through July 2004). |
| RTECS®- TLV/BEI,2005 [shown for informational purposes only] | RTECS®- TLV/BEI,2005 |
| RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 [shown for informational purposes only] | RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 -,127,1977 |
| RTECS®- Environmental and Molecular Mutagenesis 1993 [shown for informational purposes only] | RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 21,160,1993 |
| RTECS®- Environmental Mutagen Society 37th Annual Meeting Abstracts 2006 [shown for informational purposes only] | RTECS®- Environmental Mutagen Society 37th Annual Meeting Abstracts. Poster Session Abstracts. Poster Session I -,444,2006 |
| RTECS®- Mutation Research 1998 [shown for informational purposes only] | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 414,15,1998 |
| RTECS®- Mutation Research 1998 [shown for informational purposes only] | RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 414,15,1998 |
| RTECS®- Toxicologist 2005 [shown for informational purposes only] | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 44,213,2005 |
| RTECS®- Toxicologist 2005 [shown for informational purposes only] | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 44,294,2005 |
| RTECS®- Toxicologist 2002 [shown for informational purposes only] | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 66,118,2002 |
| RTECS®- Toxicologist 2002 [shown for informational purposes only] | RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 66,353,2002 |
| RTECS®- Toxicology In Vitro 1987 [shown for informational purposes only] | RTECS®- Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- 1,71,1987 |
| RTECS®- Toxicology Letters 2003 [shown for informational purposes only] | RTECS®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 142,71,2003 |
| RTECS®- United States Environmental Protection Agency, Office of Pesticides and Toxic Substances 1994 [shown for informational purposes only] | RTECS®- United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. #86940001000,1994 |
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