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Score
Data: Good
CAS13463-67-7
eye shadow (1,813 products)
lipstick (1,315 products)
foundation (1,242 products)
lip gloss (960 products)
nail polish (689 products)
Show all 10,308 products that contain TITANIUM DIOXIDE.
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TITANIUM DIOXIDE


image source: PubChem
Health concerns of ingredient
About the ratings
Canceryes
Developmental & reproductive toxicity no information
Allergies & immunotoxicityyes
Use restrictions no information
Contamination concerns: none
Other HIGH concerns: Occupational hazards
Other MODERATE concerns: Organ system toxicity (non-reproductive)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Colorant; Opacifying Agent; Sunscreen Agent; Ultraviolet Light Absorber

About TITANIUM DIOXIDE: Titanium dioxide is an inorganic compound used in a range of body care products such as sunscreens and makeup. It appears to have low skin penetration but inhalation is a concern.

Synonym(s): PIGMENT WHITE 6; AMORPHOUS TITANIUM DIOXIDE; CI 77891; MICRO PARTICLE TITANIUM DIOXIDE; TITANIUM DIOXIDE SOL; TITANIUM OXIDE; TITANIUM DIOXIDE; TITANIUM DIOXIDE; TITANIUM OXIDE (TIO2) ; TIO2; 1385RN 59; 1700 WHITE

Cancer

type of concern product conditions reference
Limited evidence of carcinogenicity products that may be aerosolized (airborne)  NIOSH Occupational Carcinogens
Limited evidence of carcinogenicity products that may be aerosolized (airborne)  Int'l Agency for Research on Cancer (IARC) - Carcinogens
show more

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as expected to be toxic or harmful    Environment Canada Domestic Substance List
Classified as medium human health priority    Environment Canada Domestic Substance List

Allergies/immunotoxicity

type of concern product conditions reference
Limited evidence of immune toxicity products that may be aerosolized (airborne)  CHE Toxicant and Disease Database

Occupational hazards

type of concern product conditions reference
Allowed workplace exposures restricted to low doses    National Library of Medicine HazMap

Decreased skin absorption

type of concern product conditions reference
No absorption into intact skin    Gamer, A, 2006

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
10,535 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study appears on list as classification(s)
CHE Toxicant and Disease DatabaseTITANIUM DIOXIDEImmune suppression * - Limited
FDA Color Additive StatusTITANIUM DIOXIDECosmetics: Y; Food: Y; Drugs: Y; Eye: Y
FDA Color Additive StatusTITANIUM DIOXIDEMedical Device
FDA Everything Added to FoodTITANIUM DIOXIDE• ASP
Environment Canada Domestic Substance ListTITANIUM OXIDE (TIO2)Y-Categorization,Y-Human health,Moderate-Health Priority,Y-Persistent,,,,,,
CTFA International Cosmetic Ingredient Dictionary and HandbookTITANIUM DIOXIDEColor Additives - Exempt from Batch Certification by the U.S. Food and Drug Administration
IFRA Fragrance Ingredient ListTITANIUM OXIDE (TIO2)reported as used in fragrance compounds in 2008
National Library of Medicine HazMapTITANIUM DIOXIDESD: No;PE: 15 mg/m3, total dust;TL: 10 mg/m3;ID: 5000 mg/m3;MA: 1.5 mg/m3, respirable fraction;
Int'l Agency for Research on Cancer (IARC) - CarcinogensTITANIUM DIOXIDEIARC GROUP 2B
NIOSH Occupational CarcinogensTITANIUM DIOXIDENIOSH potential occupational carcinogens
Gamer, A, 2006TITANIUM DIOXIDEThe amounts of titanium found in the tape strips and skin preparations were in the order of the analytical determination limit. No Ti was found in the receptor fluid at any sampling time.
Opinion of the Scientific Committee on Cosmetic Products and non-food products intended for consumers concerning Titanium Dioxide, 2000TITANIUM DIOXIDESCCNFP review of Titanium Dioxide did not identify relevant in vivo reproductive/developmental toxicity studies
California EPA, Office of Environmental Health Hazard Assessment, 2004TITANIUM DIOXIDECancer Hazards: suspected

Other RTECS® classifications [shown for informational purposes only]

government/industry list/academic study appears on list as classification(s)
RTECS®- TLV/BEI,2005TITANIUM DIOXIDE• occupationally related - ACGIH TLV (human TWA)
RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977TITANIUM DIOXIDE• skin - Primary skin irritant ( human )
RTECS®- Environmental and Molecular Mutagenesis 1993TITANIUM DIOXIDE• mutagenic - Positive mutation assay: Micronucleus test (mouse ipr)
RTECS®- Environmental Mutagen Society 37th Annual Meeting Abstracts 2006TITANIUM DIOXIDE• mutagenic - Positive mutation assay: DNA Damage ( human lng)
RTECS®- Mutation Research 1998TITANIUM DIOXIDE• mutagenic - Positive mutation assay: Micronucleus test (hamster ovr)
RTECS®- Mutation Research 1998TITANIUM DIOXIDE• mutagenic - Positive mutation assay: Micronucleus test (hamster ovr)
RTECS®- Toxicologist 2005TITANIUM DIOXIDE• biochemical - Effect on inflammation or mediation of inflammation (rat TCLo)
• respiratory - Other changes (rat TCLo)
RTECS®- Toxicologist 2005TITANIUM DIOXIDE• cardiovascular - Regional or general arteriolar constriction (rat TDLo)
RTECS®- Toxicologist 2002TITANIUM DIOXIDE• respiratory - Other changes (rat TDLo)
RTECS®- Toxicologist 2002TITANIUM DIOXIDE• biochemical - Effect on inflammation or mediation of inflammation (rat TDLo)
• respiratory - Other changes (rat TDLo)
RTECS®- Toxicology In Vitro 1987TITANIUM DIOXIDE• mutagenic - Positive mutation assay: DNA Inhibition (hamster lng)
RTECS®- Toxicology Letters 2003TITANIUM DIOXIDE
RTECS®- United States Environmental Protection Agency, Office of Pesticides and Toxic Substances 1994TITANIUM DIOXIDE• gastrointestinal - Hypermotility, diarrhea (rat TDLo)

references

government/industry list/academic study reference
CHE Toxicant and Disease DatabaseCHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database.
FDA Color Additive StatusFDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
CTFA International Cosmetic Ingredient Dictionary and HandbookCTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Int'l Agency for Research on Cancer (IARC) - CarcinogensIARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
NIOSH Occupational CarcinogensNIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
Open scientific literatureGamer, A. O., E. Leibold, et al. (2006). "The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin." Toxicology in Vitro 20: 301-307.
Open scientific literatureOpinion of the Scientific Committee on Cosmetic Products and non-food products intended for consumers concerning Titanium Dioxide. Colipa n° S75. Adopted by the SCCNFP during the 14th plenary meeting of 24 October 2000
Scorecard.org Toxicity InformationCalifornia EPA, Office of Environmental Health Hazard Assessment. Prioritization Notices. http://www.oehha.org/prop65/CRNR_notices/state_listing/prioritization_notices/index.html. Chemicals on Candidate List for consideration under Proposition 65 due to high carcinogenicity concern (through March 2004). Chemicals under consideration for listing via the authoritative bodies mechanisms (through July 2004).
RTECS®- TLV/BEI,2005 [shown for informational purposes only]RTECS®- TLV/BEI,2005
RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 [shown for informational purposes only]RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 -,127,1977
RTECS®- Environmental and Molecular Mutagenesis 1993 [shown for informational purposes only]RTECS®- Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- 21,160,1993
RTECS®- Environmental Mutagen Society 37th Annual Meeting Abstracts 2006 [shown for informational purposes only]RTECS®- Environmental Mutagen Society 37th Annual Meeting Abstracts. Poster Session Abstracts. Poster Session I -,444,2006
RTECS®- Mutation Research 1998 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 414,15,1998
RTECS®- Mutation Research 1998 [shown for informational purposes only]RTECS®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 414,15,1998
RTECS®- Toxicologist 2005 [shown for informational purposes only]RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 44,213,2005
RTECS®- Toxicologist 2005 [shown for informational purposes only]RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 44,294,2005
RTECS®- Toxicologist 2002 [shown for informational purposes only]RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 66,118,2002
RTECS®- Toxicologist 2002 [shown for informational purposes only]RTECS®- Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- -1981 66,353,2002
RTECS®- Toxicology In Vitro 1987 [shown for informational purposes only]RTECS®- Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- 1,71,1987
RTECS®- Toxicology Letters 2003 [shown for informational purposes only]RTECS®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 142,71,2003
RTECS®- United States Environmental Protection Agency, Office of Pesticides and Toxic Substances 1994 [shown for informational purposes only]RTECS®- United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. #86940001000,1994

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