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TETRASODIUM EDTA
Score
Data: Fair
CAS64-02-8
shampoo (356 products)
body wash/ cleanser (276 products)
facial moisturizer/ treatment (212 products)
moisturizer (199 products)
facial cleanser (151 products)
Show all 2,514 products that contain TETRASODIUM EDTA.
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TETRASODIUM EDTA


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other HIGH concerns: Enhanced skin absorption, Occupational hazards
Other MODERATE concerns: Organ system toxicity (non-reproductive)
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Chelating Agent

About TETRASODIUM EDTA: EDTA (ethylenediaminetetraacetic acid) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in a product.

Synonym(s): EDETATE SODIUM; N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL) GLYCINE] , TETRASODIUM SALT; GLYCINE, N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL) -, TETRASODIUM SALT; SODIUM EDETATE; TETRASODIUM EDETATE; TETRASODIUM EDETATE DIHYDRATE; TETRASODIUM EDE TATE TETRAHYDRATE; TETRASODIUM ETHYLENE DIAMINE TETRAACETATE; TETRASODIUM SALT N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL) GLYCINE] ; TETRASODIUM SALT GLYCINE, N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL) -; N,N'-1,2-ETHANEDIYLBIS [N- (CARBOXYMETHYL) - TETRASODIUM SALT GLYCINE

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Classified as expected to be toxic or harmful    Environment Canada Domestic Substance List
Limited evidence of eye toxicity products for use around the eyes  European Union - Classification & Labelling

Occupational hazards

type of concern product conditions reference
Allowed workplace exposures restricted to low doses    European Union - Classification & Labelling

Enhanced skin absorption

type of concern product conditions reference
Penetration enhancer    Cosmetic Ingredient Review Assessments

Data gaps

type of concern product conditions reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   Cosmetic Ingredient Review Assessments
2,416 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
European Union - Classification & LabellingTETRASODIUM ETHYLENE DIAMINE TETRAACETATEXn; R22 Xi; R41
Cosmetic Ingredient Review AssessmentsTETRASODIUM EDTAQQQ01,QQQ11; D+, R+, M-, PE
FDA Everything Added to FoodEDTA, TETRASODIUM• ASP
Environment Canada Domestic Substance ListGLYCINE, N,N'-1,2-ETHANEDIYLBIS[N-(CARBOXYMETHYL)-, TETRASODIUM SALTY-Categorization,Y-Human health,Moderate-Health Priority,,,,,,,
IFRA Fragrance Ingredient ListGLYCINE, N,N'-1,2-ETHANEDIYLBIS[N-(CARBOXYMETHYL)-, TETRASODIUM SALTreported as used in fragrance compounds in 2008

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J 1972TETRASODIUM EDTA• sense organ - Primary eye irritant (rabbit )
• skin - Primary skin irritant (rabbit )
RTECS®- AMA Archives of Ophthalmology 1952TETRASODIUM EDTA• sense organ - Primary eye irritant (rabbit )
RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002TETRASODIUM EDTA• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Revue d'Epidemiologie, Medecine Sociale et Sante Publique 1962TETRASODIUM EDTA• kidney or renal system - Changes in tubules (including acute renal failure, acute tubular (mouse LD50)

references
government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Cosmetic Ingredient Review AssessmentsCIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS®- "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J 1972 [shown for informational purposes only]RTECS®- "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 -,306,1972
RTECS®- AMA Archives of Ophthalmology 1952 [shown for informational purposes only]RTECS®- AMA Archives of Ophthalmology. (Chicago, IL) V.44(4)-63, 1950-60. For publisher information, see AROPAW. 48,681,1952
RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V 2002 [shown for informational purposes only]RTECS®- International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997- 21,95,2002
RTECS®- Revue d'Epidemiologie, Medecine Sociale et Sante Publique 1962 [shown for informational purposes only]RTECS®- Revue d'Epidemiologie, Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.1- 1953- 10,391,1962

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